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The Relationship Between Attachment, Recidivism and Treatment in Forensic Patients with Mental Illness
Principal Investigator
Dr. Gheorghita Adams
Psychiatry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Mansfield Mela
Co-Investigator(s)
Andrea Kotlar-Livingston
Anne McKenna
Anita Andreen
Olajide Adelugba
2016-2017 Collaborative Innovation Development
FUNDING RECEIVED
$48,923SHRF
Description
Criminality and mental illness represent a hard to treat and costly combination with risks for the population at large. This is highly concerning in Saskatchewan given the increase in the rate of supervised offenders that exceeds all other provinces. Although sparse, studies of Mentally Disordered Offenders (MDOs) show high rates of childhood trauma, long-standing difficulties in relationships, costly and minimally successful treatments. Moreover, after release, MDOs re-offend faster and more frequently than their counterparts without mental illness. Attachment style is a pattern of viewing and behaving in relationships developed in childhood through interactions with caregivers. Attachment persists throughout life, represents a risk factor for mental illness and relational problems, and impacts the engagement and success of treatments. However, studies exploring attachment in the forensic population are lacking. Forgiveness has been recently shown to have remarkable curative potential in preventing criminal behavior and improving the quality of relationships. The current study aims to explore the relationship between the attachment style of MDOs in the context of childhood trauma, their recidivism risk and capacity to forgive, as well as their engagement in psychiatric treatment and the associated costs. The goal of the project is to identify factors that could improve the health of MDOs, decrease healthcare costs and reduce recidivism. The study benefits from a significant team of forensic clinicians and experienced researchers, as well as the involvement of end-users and advisors with direct experience in forensics.
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Improving Capacity to Reduce Fall-Related Injury Risk in Older Adults
Principal Investigator
Dr. Catherine Arnold
Physical Therapy
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Ian Stavness
Margareth Peterson
Graham Fast
Soo Kim
Janet Barnes
Howard Giles
Jonathan Farthing
Jenny Basran
Melanie Weimer
2016-2017 Targeted Collaborative Innovation Development Grant (SPOR)
Two Year
FUNDING RECEIVED
$74,890SHRF
Description
Fall-related injuries among seniors are common and cost the health care system about $2 billion every year. Women have higher rates of fall-related fractures, but men and women have equal rates of other serious fall injuries such as brain injury. Fall Arrest Strategy Training (FAST) is a unique, simple exercise program designed to improve one's ability to prevent injury when a fall is unavoidable. FAST, now successfully integrated into a Saskatoon Health Region community program called Staying on Your Feet (SOYF), decreases fall risk and improves strength and mobility. Women are more likely to take part in SOYF than men. The purpose of this project is to test differences between men and women's physical capacity to control the downward descent of a forward fall and prevent injury and to understand factors that influence participation of women and men in fall prevention programming. A total of 60 seniors (30 men and 30 women) age 60 years or older will do their regular activities for 12 weeks followed by 12 weeks of FAST training. They will be tested before and after for muscle strength, balance and their ability to land and descend in a simulated forward fall using a safe protocol in our lab. Group discussions among women and men after FAST will help us determine facilitators and barriers to exercise participation. This is a new direction for fall prevention research, focusing on the important goals of both fall prevention and injury prevention in the event where a fall is unavoidable. This study aims to improve the quality of life and physical mobility of older adults by preventing the downward spiral of failing health, admission to long term care and even death following a serious fall-related injury.
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Evaluation of Gait Variability in Individuals with Relapsing-Remitting MS Using an iOS Gait Variability App.
Principal Investigator
Dr. John Barden
Kinesiology and Health Studies
University of Regina
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
David Gerhard
Abdulhakim Raghig
Jennifer St.Onge
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$46,799SHRF
Description
Multiple sclerosis (MS) is a progressive neurological disease that has a significant impact on an individual's health and mobility. Canada has the highest rates of MS in the world, while the Prairie provinces have some of the highest rates in Canada. The ability to walk, which is essential for functional independence and quality of life, is compromised in persons with MS (pwMS) and can be assessed by determining the basic characteristics of gait (e.g. stride time, stride length, etc.). While these basic characteristics can be used to assess impaired mobility, measuring their variability allows for improved assessments and insight into the more subtle differences in gait function. Normal gait is also made up of complex (fractal) patterns that have been shown to predict falls and diminished gait capacity in other neurological conditions such as Parkinson's disease. Only a handful of studies have looked at gait variability in pwMS, and while stride time variability appears to be associated with an increased fall risk, no study has investigated the fractal patterns of gait in pwMS. Consequently, this project will investigate the relationship between gait variability, fractal patterns and disability level in individuals with relapsing-remitting MS. A smartphone-based motion sensor will be used to measure the variability and fractal pattern of stride time during a 6-minute walk test, which is a validated measure of walking capacity in pwMS. This study will provide a foundation for future projects that will investigate the relationship between gait variability and fall risk in pwMS.
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Does Matching Treatment Rationale with Individuals' Explanatory Models of Depression Improve Perceptions of Cognitive-Behavioural Therapy for Depression?
Principal Investigator
Dr. Shadi Beshai
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Murray Abrams
Lisa Watson
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$34,028SHRF
Description
Depression affects 12% of Canadians in their lifetime, and is a condition that interferes with all domains of life. Cognitive-behavioural therapy (CBT) is one of the most evaluated and effective treatments for depression. Unfortunately, many sufferers are unaware of this safe treatment, or believe that CBT will be ineffective to treat their depression. Results of a pilot project conducted by the applicants, in addition to a growing literature on CBT marketing, indicate that the majority of individuals adopt a non-cognitive explanatory model of depression, and if such individuals are provided with generic information about CBT, they tend to harbor negative perceptions of the treatment. As such, this project has two phases. In the first phase, the team will tailor the generic message of CBT for depression to fit with the three most endorsed explanatory models of depression (biological, interpersonal and environmental). In the second phase, the ability of these tailored rationales to influence perceptions of CBT will be evaluated among a sample of participants recruited online. Half of the participants will receive a CBT message consistent with their baseline model of depression, while the other half will receive a generic message. We hypothesize that those receiving tailored messages will have more positive perceptions of the effectiveness and logic of CBT than those in the generic condition. Adapting treatment rationale will help improve patient "buy-in" to treatment. Given the prevalence of depression in Saskatchewan, the results of this study will be highly relevant to the mental health of Saskatchewan's residents.
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Indigenous Water Forum: Bridging Cultural Knowledges on Water and Health
Principal Investigator
Dr. Lalita Bharadwaj
School of Public Health
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Rebecca Zagozewski
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$10,000SHRF
Description
The Indigenous Water Forum will function as a catalyst for the bridging of cultural knowledges for water and health. It will be held on June 8-9, 2016 at the Gordon Oakes Red Bear Student Centre at the University of Saskatchewan campus. The goals of the forum are to: 1) facilitate learning of, and a sense of respect for, Indigenous ways of knowing regarding water and its impact on health; 2) serve as a knowledge dissemination session to inform First Nations community members on previous research regarding the barriers and challenges to safe drinking water, source water protection, and waste water challenges in communities ; and 3) facilitate research relationships on water and health between faculty and students, First Nations communities, and businesses focused on the promotion of healthy water and lifestyles. Targeted invitees include faculty and students engaged in water and health research in a variety of colleges and schools across the U of S campus, as well as other Canadian Universities; First Nations community members and leaders within Saskatchewan and Alberta; Indigenous and Northern Affairs Canada representatives; and Health Canada representatives.
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Mechanisms Underlying Autonomic Neuropathy in Cystic Fibrosis
Principal Investigator
Dr. Veronica Campanucci
Physiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Julian Tam
George Katselis
Juan Ianowski
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$50,000SHRF
Description
Cystic Fibrosis (CF) is a life-shortening genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Defects in CFTR impairs epithelial transport, which is the hallmark defect in CF. Many of the features observed in CF patients and organs affected in CF are modulated by the nervous system. In fact, CFTR expression has been reported in both the peripheral and central nervous systems, in which is believed to modulate neuronal excitability. Thus, lack of CFTR in the nervous system affects neuronal function and several nervous system abnormalities and nervous system disorders have been described in people with CF and animal models of CF. There is a growing body of evidence of autonomic nervous system dysfunction (neuropathy) in CF. Autonomic neuropathy refers to a collection of syndromes resulting from poor autonomic control. The autonomic nervous system (ANS), which is largely responsible for the regulation and function of nearly all organ systems, maintains internal homeostasis. Among the clinical phenotypes caused by autonomic abnormalities in CF, gastrointestinal (GI) dysfunction is one of the most concerning complications. In addition to impaired expression of CFTR in the GI tract, which contributes to thick mucus accumulation and electrolyte imbalance, autonomic dysfunction leads to impaired gut motility and intestinal obstruction. In the current study we will investigate the underlying mechanisms of neuronal malfunction in animal models of CF, and with the ultimate goal of developing techniques to diagnose and monitor autonomic dysfunction in CF, and to identify new molecular targets for CF patients.
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Therapeutic Potential of Novel Dimer Drugs in a New Rat Model of Parkinson's Disease
Principal Investigator
Dr. Francisco Cayabyab
Surgery
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Ivar Mendez
Jeremy Lee
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$50,000SHRF
Description
According to the World Health Organization, more than 10% of Canadians suffer from neurological conditions, such as Parkinson's disease (PD), which is more prevalent in Canada's aging population. Canada's senior population (>65 years old) is growing, and comprises nearly 15% of Saskatchewan's total population. The incidence of PD is expected to rise as the percentage of Saskatchewan's aging demographics will likely double by 2026 when more than one in five Canadians will be expected to be 65 or older. The present proposal addresses the needs of seniors who suffer from PD, which is characterized by loss of brain cells that control movement. Currently there is no cure for PD, and traditional animal models of PD inadequately mimic the early cellular events involved in the progressive destruction of neurons that produce the brain chemical dopamine. We are developing a new rat PD model that better reflects the physiology of the aging brain. We aim to characterize how elevation of another brain chemical adenosine triggers loss of dopaminergic nerves, which results in PD-like symptoms. Pilot studies revealed that our novel rat PD model recapitulates some of the movement and cognitive abnormalities seen in PD patients. We also aim to introduce into animals potential neuroprotective agents to determine whether the progression of PD-like symptoms and nerve degeneration in the motor regions of the brain can be halted in our PD model. This study represents a critical first step in developing a combinatorial treatment that will ultimately help the aging population living with PD.
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CFD-Based Visualization of Cerebral Aneurysms Treated with Flow-Diverting Stents
Principal Investigator
Dr. Xiongbiao (Daniel) Chen
Mechanical Engineering
Engineering
University of Saskatchewan
Co-Principal Investigator(s)
Mr. Donald Bergstrom
Co-Investigator(s)
Lissa Peeling
Michael Kelly
Mauro Malve
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$50,000SHRF
Description
A cerebral aneurysm (or brain aneurysm) is an abnormal blood-filled bulge in a blood vessel. If untreated, a cerebral aneurysm presents a high risk of rupture, and may lead to haemorrhagic stroke - a leading cause of disability and death in both Saskatchewan and Canada. Flow-diverting stents (small mesh tubes inserted into the artery) show considerable promise for the treatment of cerebral aneurysm by lowering rupture risk. Despite encouraging results of treatment with such stents, post-treatment complications have been reported at rates of 15-35%. Notably, treatment with stents can alter the local flow of blood depending on the stent, aneurysm and blood vessel. These changes further affect and determine the treatment outcome. As such, it is highly desirable for neurosurgeons to have knowledge of the local flow in the stented vessel. Aiming to provide such knowledge, this project will develop novel models to visualize cerebral aneurysms treated with stents. The specific objectives are to (1) collect patient-specific data pre- and post-treatment with stents; (2) develop novel models to visualize the local flow in stented vessels; and (3) correlate the information obtained from the models to treatment outcome, thus providing neurosurgeons with a means to optimize the outcome of stent treatment. This project will be pursued in a collaborative effort involving three engineers (Drs. Chen, Bergstrom, and Malve) and two neurosurgeons (Drs. Kelly and Peeling). The knowledge generated will be transferred to the practices of Drs. Kelly and Peeling for cerebral aneurysms using FD stents, thus directly benefiting Saskatchewan patients.
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Towards a porcine model of tuberculosis aerosol transmission
Principal Investigator
Dr. Jeffrey Chen
Vaccine and Infectious Disease Organization - International Vaccine Centre
VIDO-InterVac
University of Saskatchewan
Co-Principal Investigator(s)
Mr. Donald Bergstrom
Co-Investigator(s)
Lissa Peeling
Michael Kelly
Mauro Malve
2016-2017 Establishment Grants
Three Year
FUNDING RECEIVED
$120,000SHRF
Description
In 2014 alone, Mycobacterium (M.) tuberculosis, the agent of human tuberculosis, killed 1.5 million and sickened 9.6 million people world-wide. Tuberculosis control is a public health priority in Canada, especially in the province of Saskatchewan which has a tuberculosis incidence rate almost twice the national average. Furthermore, with the emergence of multi-antibiotic resistant M. tuberculosis strains posing an increasing threat to global public health, better anti-tuberculosis vaccines and drugs are urgently needed. A key step in the spread of tuberculosis is the cough-mediated expulsion of M. tuberculosis into the surrounding air by symptomatic infected individuals and its subsequent uptake by naïve susceptible individuals. Blocking tuberculosis transmission would be a promising and highly effective way to control the disease. However, the drivers of tuberculosis aerosol transmission remain poorly defined. To better understand M. tuberculosis aerobiology and identify ways to block its spread we propose to develop a pig model of tuberculosis aerosol transmission. To achieve this goal we will: 1) determine the optimal dose and route of experimental M. tuberculosis infection required to result in symptomatic coughing pigs. 2) determine if infected coughing pigs generate aerosols containing viable M. tuberculosis. 3) identify biomarkers associated with symptomatic and transmissible tuberculosis in pigs. 4) determine if M. tuberculosis can be spread in aerosols from infected coughing pigs to naïve pigs. A robust pig model of tuberculosis aerosol transmission will ultimately facilitate the testing and development of novel vaccines and therapies that target the spread of this disease.
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Academic Health Sciences Student Research Day 2016
Principal Investigator
Mr. Adam Clay
Research and Performance Support
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Mr. Donald Bergstrom
Co-Investigator(s)
Megan Vanstone
2016-2017 Research Connections Grants
Three Year
FUNDING RECEIVED
$4,050.65SHRF
Description
Academic Health Sciences Student Research Day is a half-day research event in October hosted in the concourse of the Wascana Rehabilitation Centre. The event is open to all undergraduate, graduate and resident researchers who would like to share their research projects in poster format with the RQHR community. Students who have completed a University of Saskatchewan Undergraduate Medicine Dean’s Project in the summer are required to present. Students submit their research for poster presentations and are evaluated for prizes in different areas during the event by a panel of local judges. Researchers, clinicians and faculty members from medicine, nursing, pharmacy, psychology, kinesiology and health studies are all invited so that students have the opportunity mingle with colleagues from other health science faculties throughout the afternoon.
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National Summit on the Control of Agricultural Injury and Death in Canada: Transforming today’s science into tomorrow’s prevention
Principal Investigator
Dr. James Dosman
Canadian Centre for Health & Safety in Agriculture
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Mr. Donald Bergstrom
Co-Investigator(s)
Shelley Kirychuk
Niels Koehncke
2016-2017 Research Connections Grants
Three Year
FUNDING RECEIVED
$7,500SHRF
Description
The aim of the National Summit is to bring together researchers & students, industry partners, knowledge transfer specialists, policy makers, and end users (including agricultural producers) from across Saskatchewan and Canada to discuss the state of applied research in key topic areas in safety and health in agriculture, and develop an applied research agenda to address key issues affecting the health and safety of producers, agricultural workers, farm families, and rural people. The event will be held at TCU Place in Saskatoon, SK on Tuesday June 7, and is open to any individuals and organizations who have an interest in research-based approaches to health and safety in agriculture.
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Targeting resistance to anti-EphA2 treatment in breast cancer
Principal Investigator
Dr. Amr El Zawily
Pathology and Laboratory Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Mr. Donald Bergstrom
Co-Investigator(s)
Shelley Kirychuk
Niels Koehncke
Supervisor(s)
Dr. Andrew Freywald (Lead Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
Breast cancer is the most frequent malignancy in women, with an average of 500 Canadians diagnosed with this cancer every day. So-called triple-negative breast cancer (TNBC) tumors that lack expression of the estrogen, progesterone and HER2 receptors represent the deadliest type of this disease. In collaboration with Biomirex Inc., we recently generated a novel synthetic antibody that targets a cell surface molecule, EphA2 (anti-EphA2). Excitingly, application of anti-EphA2 efficiently suppresses human TNBC tumors in experimental animals. However, a small percentage of cancer cells become resistant to this treatment and are likely to trigger tumor recurrence following the initial therapy. To further improve tumor elimination, we plan to use a novel approach called "Synthetic Lethality" (SL), where an inhibition of a SL gene selectively kills only cancer cells carrying a specific genetic alteration, while not affecting healthy cell populations. We plan to use genome-wide SL screening to find genes SL with resistance of TNBC tumors to anti-EphA2. When identified, these genes will be validated both in cell culture and in animal models of human TNBC for their potential usefulness to breast cancer therapy. Identification and validation of these SL genes is expected to trigger the development of new efficient therapeutic approaches, relying on targeting SL genes simultaneously with anti-EphA2 application. These treatments are likely to eradicate TNBC tumors and significantly improve patient survival. This is important, as currently there is no effective therapy for TNBC and it is associated with a very high rate of patient mortality.
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The impact of amino acid depletion and metformin treatment on Hutchinson Gilford Progeria Syndrome genome function and structure
Principal Investigator
Dr. Christopher Eskiw
Food and Bioproduct Sciences
Agriculture and Bioresources
University of Saskatchewan
Co-Principal Investigator(s)
Mr. Donald Bergstrom
Co-Investigator(s)
Shelley Kirychuk
Niels Koehncke
2016-2017 Establishment Grants
Three Year
FUNDING RECEIVED
$120,000SHRF
Description
Children suffering from the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) succumb to age-related complications, such as heart attack or stroke at ~14 years of age. HGPS results from a single mutation which generates a toxic protein called Progerin. Progerin disrupts the function and organization of our genetic material (genome) causing our cells to become ‘old' (senescent) at increased rates. Current HGPS therapies have shown limited results and have severe side effects and therefore, new strategies are required for the treatment of this devastating childhood disease. Recently, rapamycin, an immuno-suppressant, has been shown to cause HGPS cells to preferentially degrade Progerin. This coincides with a significant decrease in the rates at which cells age. Although promising, there are concerns over potential side effects associated with rapamycin and its ability to completely restore genome function and organization. Our aim is to test alternative strategies which mimic rapamycin to determine if they are potential treatments for HGPS. We will treat HGPS cells with the anti-diabetic drug metformin or decreased levels of amino acids and determine if this causes Progerin degradation, improves genome function/organization, and decreases the rates at which HGPS cells become senescent. Although HGPS is relatively rare, afflicting only 1 in 4 million live births, Progerin has been identified in cells from normal older individuals. Therefore, the results from this research could provide understanding into the molecular mechanisms associated with the normal aging process to facilitate increased health later in life.
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Establishing the incidence and prevalence of multiple sclerosis in Saskatchewan
Principal Investigator
Dr. Charity Evans
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Mr. Donald Bergstrom
Co-Investigator(s)
Katherine Knox
2016-2017 Establishment Grants
Three Year
FUNDING RECEIVED
$78,700SHRF
Description
Multiple sclerosis (MS) is a chronic, degenerative disease, which places a considerable burden on patients, families and society. The lifetime cost of MS is estimated at $1.6 million per affected person. Canada has one of the highest rates of MS in the world, with approximately 100,000 people affected. Saskatchewan is estimated to have one of the highest rates of MS in Canada, but the actual number of people with the disease is unknown. This goal of this study is to determine how many people in Saskatchewan currently have MS (prevalence) and how many people are being diagnosed with MS every year (incidence). To do this, we will use datasets from the provincial government, which collects information on health care use for almost all residents in the province. These data will allow us to define individuals with MS based on their use of health care for reasons that are likely related to MS. However, to make sure we correctly identify individuals with MS, we must test a number of definitions to find which one is the most accurate for our Saskatchewan data. We will then use this definition to determine the incidence and prevalence of MS in Saskatchewan. Knowing the actual incidence and prevalence of MS is extremely important to help inform decisions related to treatment, health care delivery, policy development and resource planning, and will ultimately benefit those individuals affected by MS.
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Aboriginal Youth Mentorship Program in Saskatchewan
Principal Investigator
Dr. Leah Ferguson
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Mr. Donald Bergstrom
Co-Investigator(s)
Louise Humbert
Carol Rodgers
Jon McGavock
2016-2017 CIHR Pathways to Health Equity for Aboriginal Peoples
One year
FUNDING RECEIVED
$75,000SHRF
Description
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Research Study to Initiate a Clinical Trial for Targeting Synthetic Lethality Between EPHB6 and SRC in Breast Cancer
Principal Investigator
Dr. Andrew Freywald
Experimental Pathology
Pathology and Laboratory Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Franco Vizeacoumar
Co-Investigator(s)
Sunil Yadav
Lynn Dwernychuk
2016-2017 Collaborative Innovation Development
One year
FUNDING RECEIVED
$49,858SHRF
Description
Application of tumor genome sequencing has identified numerous loss-of-function alterations in cancer cells. These alterations can be targeted using an approach called "Synthetic Lethality" (SL), where one gene causes lethality only when another gene is also inactivated. The EPHB6 receptor tyrosine kinase is often down regulated in multiple malignancies, including breast cancer, making it an attractive target for SL applications. In this approach, Drs. Vizeacoumar and Freywald took advantage of a genome-scale effort where they asked which gene should be "turned-off", such that, it kills only the tumor cells that lack EPHB6 but not the normal cells. The team identified the SRC kinase as a druggable target that can be potentially used to treat triple-negative breast cancer (TNBC) patients. The team is currently in the process of initiating clinical trial for clinical validation of targeting SRC Kinase in EphB6-deficient TNBC patients in collaboration with co-applicants Dr. Yadav as well as with the clinical Director at the Saskatchewan Cancer Agency, Ms. Lynne Dwerynchuk. However, as EPHB6 is also lost in other sub-types of breast cancer patients, in the current project, the team aims to validate SRC kinase in additional tumour models that represent different sub-types of breast cancer.
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Elucidating the roles of pathogen virulence factors in subverting host cell processes
Principal Investigator
Dr. Alla Gagarinova
Biochemistry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Franco Vizeacoumar
Co-Investigator(s)
Sunil Yadav
Lynn Dwernychuk
Supervisor(s)
Dr. Miroslaw Cygler (Lead Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
Due to increasingly widespread antibiotic resistance, it is predicted that by 2050 bacterial infections will be causing more deaths than cancers. Bacterial pathogens subvert host processes by injecting protein virulence factors (effectors) into host cells to modify the behaviors of specific host proteins, thus causing disease. However, there has been limited success in elucidating effector roles and, correspondingly, pathogenesis mechanisms. This limits the development of new treatment strategies, which are becoming essential in view of increasingly widespread antimicrobial resistance. Salmonella enterica serovar Typhimurium causes gastroenteritis and is the best-studied bacterial pathogen. However, cellular targets have been identified or predicted for only half of S. Typhimurium's 45 effectors. This research will systematically identify host proteins interacting with each of the 45 effectors during infection and use this information to predict effector roles in causing disease. For each effector, this research will use affinity purification to isolate effector protein complexes from infected macrophages, survival within which is essential for S. Typhimurium virulence. This research will then use mass spectrometry to identify proteins forming these complexes and follow the guilt-by-association principle to predict effector roles, which will be computationally and experimentally validated. The proposed project will be relevant to understanding and combatting diseases caused by Salmonella species, which result in ~116 million illnesses and ~370,000 deaths worldwide annually. Moreover, this strategy will be applicable to investigating other pathogens, thus providing new insights for understanding bacterial pathogenesis and developing new antimicrobial strategies.
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Creating a Culture of Patient and Family Engagement in Health Care: Impact of Interdisciplinary Bedside Rounds on Patient Experience and Team Collaboration
Principal Investigator
Dr. Donna Goodridge
Division of Respirology, Critical Care and Sleep Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Franco Vizeacoumar
Co-Investigator(s)
Thomas Rotter
Liz Harrison
Jordan Olfert
Erika Penz
Steven Campbell
Kelsey Kevinsen
Malori Keller
Jenny Basran
Murray Scharf
Kamma Larsen
2016-2017 Targeted Collaborative Innovation Development Grant (SPOR)
Two Year
FUNDING RECEIVED
$75,000SHRF
Description
Adoption of innovative, novel patient- and family-centred approaches is increasingly linked to better health outcomes and lower use of health services. The introduction of structured Interdisciplinary Rounds (IDR) across health regions in Saskatchewan has been deliberately designed to better engage patients in acute care settings and their families in health care, presenting a real-world opportunity to study the processes of implementation and key outcomes of this complex intervention across diverse settings. The aim of this project is to evaluate the process and selected outcomes of implementing IDR within acute care settings in Saskatchewan using a longitudinal multiple case study approach. We will specifically examine whether and how these rounds may influence the patient/family experience and team collaboration through the use of interviews, observations and questionnaires. Our team, comprised of patient advisors, health care professionals, decision-makers and researchers, possesses the breadth and depth of skills required to successfully undertake and complete this study.The longitudinal, multiple case study method we will use to study the implementation of IDR has been under-utilized in implementation research, creating the opportunity to test and refine new research approaches in quality improvement research. Findings from our project will be of direct value to the ongoing implementation of IDR throughout the province and lay the foundation for future research that strengthens the goal of promoting patient-centred care in Saskatchewan. Including the voices of patients and families with respect to the implementation of these rounds ensures that quality improvement strategies are, in fact, responding to needs of service users.
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How Do Material and Social Deprivation Affect Health Care Utilization of High System Users with Multimorbidity? A Retrospective Cohort Study
Principal Investigator
Dr. Donna Goodridge
Respirology, Critical Care and Sleep Medicine
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cory Neudorf
Co-Investigator(s)
Heather Ward
Hyun-Ja Lim
Cristina Ugolini
Sylvia Abonyi
Dylan Chipperfield
Jennifer Hiebert
Erika Penz
Lloyd Balbuena
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$50,000SHRF
Description
Saskatchewan, a province with some of the most extreme health inequities in Canada, is in the midst of a large scale transformation intended to result in reforms that promote a sustainable, patient-centred health care system. While significant attention has been directed towards understanding the characteristics of high system users in terms of single diseases, the potentially incremental effects of living with multimorbidity (the presence of two or more chronic conditions in the same individual) under conditions of material and social disadvantage have yet to be understood and addressed. Applying a health equity lens to better understand the complex associations between multimorbidity, health care utilization and the social determinants of health, we will use the robust data available through the Canadian Institute for Health Information and Statistics Canada to address key issues related to multimorbidity and social/material deprivation within Saskatchewan. Findings from this study will inform practice and policy decisions and develop future research initiatives that will promote health and system outcomes.Our project would be the first in Canada to address these issues at both the individual and area levels using the innovative approach of linking records from the recently released CIHI Dynamic Cohort of High-System Users with the Social Data Linkage Environment (SDLE) available through Statistics Canada. This linkage will provide precise and accurate data that will allow us to focus on "people and populations and on the interrelationships of risk factors and illnesses rather than on specific risk factors and disease."
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Estradiol variability and the emergence of depressive symptomatology during the menopause transition
Principal Investigator
Dr. Jennifer Gordon
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Cory Neudorf
Co-Investigator(s)
Laurie Sykes Tottenham
Tory Eisenlohr-Moul
Amanda Scollan
2016-2017 Establishment Grants
Three Year
FUNDING RECEIVED
$119,985SHRF
Description
The menopause transition or 'perimenopause' represents the five to six years surrounding the last menstrual period. During this transition, women are two to four times more likely to develop depression than any other time in their lives. Though it is commonly assumed that perimenopausal depression results from an increased sensitivity to the hormonal changes that accompany the menopause transition, this assumption remains to be tested. The proposed study will therefore test the “hormonal sensitivity” hypothesis of perimenopausal depression. The proposed study will enroll 100 healthy perimenopausal women from the community who will undergo two study phases: Phase I (lasting 12 weeks), during which participants will, once weekly, monitor their mood and collect a urine sample to allow for hormonal measurements, and Phase II (lasting 9 months), during which they will complete a monthly mental health survey. This study will have two objectives: 1) to examine the relationship between week-to-week hormone fluctuation and weekly mood during Phase I, and 2) to examine mood sensitivity to hormone fluctuation as a predictor of perimenopausal depression development in Phase II.This study represents a crucial first step in understanding why some women are at increased risk for depression during the menopause transition. The results of this study will directly inform the development of pharmacological interventions, such as the use of hormone therapy to stabilize hormone levels, to treat and prevent perimenopausal depression, which affects 26-33% of women.
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Assessing the Neurobiology of Motor Recovery After Stroke With and Without Cross-Education Rehabilitation
Principal Investigator
Dr. Layla Gould
Surgery
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cory Neudorf
Co-Investigator(s)
Laurie Sykes Tottenham
Tory Eisenlohr-Moul
Amanda Scollan
Supervisor(s)
Dr. Michael Kelly (Lead Supervisor) Dr. Jonathan Farthing (Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
Stroke is the leading cause of adult disability and the third leading cause of death in Saskatchewan. Each year in the province about 2,000 people suffer a stroke, and as many as 88% of those patients suffer severe limb weakness or paralysis that severely disrupts their daily activities. Despite its prevalence, there is little agreement on optimal treatment, and there remains great variation in current rehabilitation practices. An innovative approach to stroke rehabilitation is ‘cross-education,' which involves physically training the healthy limb to benefit the injured limb. Cross-education has the potential to ‘boost' function of the impaired limb leading to more complete recovery. The purpose of this research is to apply cross-education combined with usual care, as part of a strengthening program to improve hand function post-stroke. Functional magnetic resonance imaging will be used to track changes in brain activation, especially in motor and sensory regions, following motor recovery with and without cross-education. Diffusion tensor imaging will be used to examine differences in cortical thickness in regions-of-interest. The abovementioned neuroimaging methods will help gain insight into the neurobiological mechanisms involved in hand motor recovery in subacute stroke. This novel rehabilitation strategy will be compared to usual care alone, and will be the first neuroimaging study to examine this outcome. By studying this rehabilitation method and applying neuroimaging techniques, we are helping to identify changes in specific brain regions that are involved in motor recovery after stroke, and helping to define more effective stroke rehabilitation strategies, leading to better patient outcomes.
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Exploring the Effectiveness of an In-Person Integrated Counselling Training Module to Increase Exercise Providers' Knowledge and Beliefs to Instruct and Educate Saskatchewan Adults With Chronic Non-Cancer Pain
Principal Investigator
Dr. Nancy Gyurcsik
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Susan Tupper
Co-Investigator(s)
Pamela Downe
Laurie-ann Hellsten
Larry Brawley
Danielle Brittain
Bart Arnold
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$49,979SHRF
Description
One in five Saskatchewan adults live with chronic non-cancer pain, which negatively affects their mental health and physical functioning. Pain health care costs exceed those for each of heart disease, cancer and diabetes. Medications are the usual treatment strategy for pain management, yet they are largely ineffective. In contrast, exercise helps with pain management. Since most adults with pain do not exercise regularly, recommendations are that they should be counselled on exercising with pain (called integrated counselling). Our pilot research identified exercise providers (instructors/personal trainers) are the desired delivery agents of integrated counselling. However, providers receive no integrated counselling training by their certification bodies. They also report low pain knowledge, low confidence to counsel and inaccurate fears that participant pain during exercise signals harm, which can combine to limit their counselling efforts. To date, no research has examined training strategies to counter providers' problematic beliefs and improve their integrated counselling. Our objective is to develop, test and refine a novel 3-hour in-person exercise provider integrated counselling workshop. Study 1 compares providers trained versus untrained in our workshop with regard to differences in their knowledge on pain and appropriate exercise modifications, counselling confidence and fears about participants with pain attempting exercise. Study 2 identifies workshop strengths, limitations and potential workshop changes to facilitate future widespread delivery by provider certification organizations.Findings will inform a Canadian Institutes of Health Research application comparing pain participants, instructed by providers trained or untrained in our workshop, on exercise-promoting beliefs (e.g. exercise confidence) and exercise participation.
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Implementing the "Patient's Charter of Tuberculosis Care" in High Incidence Indigenous Communities and Across Jurisdictional Borders
Principal Investigator
Dr. Paul Hackett
Geography & Planning
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
Pamela Downe
Laurie-ann Hellsten
Larry Brawley
Danielle Brittain
Bart Arnold
2016-2017 CIHR Pathways to Health Equity for Aboriginal Peoples
Three Years
FUNDING RECEIVED
$150,000SHRF
$675,000CIHR
$100,000FNIHB-AB Region
$75,000FNIHB-SK Region
$150,000Alberta Innovates Health Solutions
$1,150,000Total
Description
Among Indigenous Peoples in the Prairie provinces tuberculosis (TB) occurs in focal pockets of incidence, such that most communities have little to no TB while a few others are very high-incidence. High incidence communities tend to be clustered together and are bound both by their geographic proximity and through kinship to members of other nearby communities. We believe that eliminating TB in these regional clusters is additionally complicated given that TB programming and the provision of services is defined by jurisdictional and geographical borders that do not reflect the mobility and realities of the people who live there. In other words, these jurisdictional borders and the resultant delineation of services tend not to be based on the realities of the people to whom TB programming is meant to relate. As such, in Component I we proposed the development of a cross-border, regional coalition to advocate for better population and community health supports that would have the downstream effect of reducing TB transmission and progression to disease. TB elimination cannot be met in isolation, but instead requires that interests of the region at large and the people living therein be considered and promoted. In Component II, this regional committee would support the implementation of two locally specific TB elimination strategies across diverse, yet interconnected, communities. Our team has identified two interrelated strategies that we will implement and evaluate in Component II. These two TB elimination strategies are: 1) improved, regional, surveillance and translation of those surveillance data back to relevant community members, and 2) an expanded program of outreach that has as its primary focus "wellness".
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Functional genetic investigation of a novel inter-organ signaling pathway critical to integrity of the immune system.
Principal Investigator
Dr. Kimberly Jett
Biochemistry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
Pamela Downe
Laurie-ann Hellsten
Larry Brawley
Danielle Brittain
Bart Arnold
Supervisor(s)
Dr. Scot Leary (Lead Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
Mitochondria are tiny compartments within the cell that fulfill multiple functions that are central to homeostasis. Gene mutations that affect any of these functions cause human diseases that collectively have a minimum estimated birth prevalence of 1 in ~3,500. The bulk of these disorders result from mutations in the protein machinery that is responsible for producing the chemical form of energy consumed by cells, and is commonly referred to as respiratory chain defects (RCDs). Patients with RCDs exhibit signs of systemic disease and typically present with symptoms that affect liver, brain and/or heart function. In general, the mechanisms that underlie these diseases are not well understood. However, emerging data suggests that the clinical symptoms in affected individuals are caused in part by the disrupted function of signalling pathways that allow different organ systems to communicate with one another. The identification of relevant inter-organ signalling pathways, while challenging, is therefore attractive from a therapeutic perspective. Using a mouse model of a human disease in which altering mitochondrial function in the liver compromised immunological integrity of the spleen and thymus, suggests that signaling between these organs is altered. Since these pathways remain largely unknown, the objective of this research is to use this mouse model to identify the factor(s) that allows for communication between the liver, thymus and spleen. The results of this research have implications for the treatment of affected individuals and as such are aligned with the determinants of health status priority area of provincial health research.
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Life and Health Sciences Research Exposition
Principal Investigator
Dr. Lisa Kalynchuk
Neurology
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
Pamela Downe
Laurie-ann Hellsten
Larry Brawley
Danielle Brittain
Bart Arnold
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$5,000SHRF
Description
The Life and Health Sciences Research Exposition is a two-day event planned for May 4 and 5, 2017 hosted by the University of Saskatchewan (U of S). It will include internationally-recognized external speakers, a networking dinner, a research day with parallel symposia and a student poster session. The poster session is open to graduate students, postdoctoral fellows, and medical residents from the health science colleges at the U of S. It is expected that 150 research posters will be submitted. Keynote speakers will speak about developing a career in the health sciences and about current hot topics in health research. Two parallel morning symposia led by researchers from Saskatchewan will focus on alternate careers in science and translating research from basic sciences to the clinic.
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Closing the Gap: Indigenous Health Innovations Forum
Principal Investigator
Dr. Tarun Reddy Katapally
Johnson Shoyama Graduate School of Public Policy
University of Regina
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
Cassandra Opikokew Wajuntah
Roger Francis
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$4,000SHRF
Description
The Saskatchewan Institute (SI) of The Conference Board of Canada, the Johnson Shoyama Graduate School of Public Policy (JSGS), the Indigenous Peoples' Health Research Centre (IPHRC) are coming together to conduct an Indigenous Health Innovations Forum aimed at highlighting innovative Indigenous health interventions in Saskatchewan. The forum will be held on May 25, 2016, at Delta Regina, Regina, Saskatchewan, The forum will bring together around 100 Indigenous scholars, elders, researchers, students, community members, policymakers, administrators and health leaders. The main goal of the event is to provide a platform for Indigenous innovations from across Saskatchewan that would demonstrate the effectiveness of Indigenous-based policymaking and program delivery as a means to tackle health inequities in Indigenous populations. The Conference Board of Canada has this event listed in its event lineup and a complete description of the event, including sponsor logos appears on the website: http://www.conferenceboard.ca/conf/16-0050/default.aspxRegistration will be conducted through this website.
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Smart Active Living Policy
Principal Investigator
Dr. Tarun Reddy Katapally
Johnson-Shoyama Graduate School of Public Policy
University of Regina
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
Mark Tremblay
Richard Larouche
Nathaniel Osgood
Justin Longo
Daniel Rainham
Scott Leatherdale
Leah Ferguson
2016-2017 Establishment Grants
Three Year
FUNDING RECEIVED
$118,500SHRF
Description
Physical activity's benefits to a wide range of health outcomes, and the overall quality of life, have been well established. Despite this evidence, a majority of the world's population is physically inactive. One major challenge is limited resources in understanding how policies and programs influence active living in populations. The proposed study introduces a highly cost-effective active living surveillance model that is relevant to human health not only in the province of Saskatchewan, but could be replicated in other provinces in Canada and elsewhere. Main objectives are: 1) to understand how active living policies and programs at national, provincial and local levels influence active living in participants in two urban jurisdictions in Saskatchewan. 2) over time, to link these policies and the environmental factors (urban design, etc.) that are driven by these polices with active living. 3) to understand and address the challenges of implementing an innovative surveillance model. The methodological approach of the surveillance model combines a policy scan with the data obtained through participants' smartphones in different seasons in accomplishing the study objectives. Participants will be recruited through a strong community partnership with the YMCAs in the cities of Moose Jaw and Regina. This approach will be highly important to population health research, as the advanced methods used here could be replicated in addressing other major public health issues.
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Optimizing in vivo assessments of cortical bone porosity and strength: A validation study linking advanced imaging, mechanical testing and finite element modeling
Principal Investigator
Dr. Chantal Kawalilak
Mechanical Engineering
Engineering
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
Mark Tremblay
Richard Larouche
Nathaniel Osgood
Justin Longo
Daniel Rainham
Scott Leatherdale
Leah Ferguson
Supervisor(s)
Dr. James (J.D.) Johnston (Lead Supervisor)
2016-2017 Research Fellowship Top-up Incentive Award
Three Year
FUNDING RECEIVED
$20,000SHRF
Description
Osteoporosis is called brittle bone disease, because it makes bones fragile and more likely to fracture, especially when a person falls. Approximately two million Canadians live with osteoporosis, costing our health care system $20 billion each year. Wrist fractures are the most common type of osteoporotic fractures. Current osteoporosis diagnostic tools are unable to identify individuals with high fracture risk. The overall goal of this research is to develop and validate a new method for determining bone strength that can be used to identify individuals at risk of wrist fracture. Synchrotron-based imaging will be used to optimize measurements of bone micro-architecture provided by advanced clinical imaging, and the development of a computer model will estimate wrist bone strength when falling onto the outstretched hand. This research is scientifically important and clinically relevant as findings will improve our understanding of how to characterize bone micro-architecture underpinning osteoporosis, bone strength and fracture risk.
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Bringing Together Physical Activity and Culture to Promote Mental Health for Indigenous Youth
Principal Investigator
Dr. Serene Kerpan
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
Mark Tremblay
Richard Larouche
Nathaniel Osgood
Justin Longo
Daniel Rainham
Scott Leatherdale
Leah Ferguson
Supervisor(s)
Dr. Sylvia Abonyi (Lead Supervisor)Dr. Sarah Oosman (Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
In Saskatchewan Indigenous youth are the fastest growing demographic and unfortunately they bear a disproportionate burden of mental health issues, including high rates of suicide. Research has identified that the promotion of culture can increase the mental health of Indigenous youth. Studies with non-Indigenous youth have shown that physical activity significantly reduces depression, anxiety, psychological distress, and emotional disturbance. Indigenous youth value physical activity because they feel it is important for their health and social connections. They also believe that traditional forms of physical activity (e.g. hunting, fishing, hiking, dancing, games) are important. For this study Indigenous worldview and physical activity will be brought together in an intervention designed to enhance the mental health of Indigenous youth. An implementation science approach coupled with participatory action research methods will be used to collaboratively develop a study with Whitecap Elementary School (WES) and Whitecap First Nation. The main goal for this research is to examine the association between a physical activity intervention and mental health for Indigenous elementary school youth in Whitecap Dakota First Nation. Community members (i.e. youth, parents, leaders, Elders) will be engaged to design, implement and evaluate this intervention. If the intervention is successful, scalability and adaptive approaches will be investigated to determine if this evidence-based strategy can be used to enhance the mental health of youth in other Indigenous communities.
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Protein Structure, Function and Malfunction Conference (PFSaM) 4th Annual Meeting
Principal Investigator
Dr. Wolfgang Koester
Vaccine and Infectious Disease Organization
Bacterial Vaccine Development
VIDO-InterVac
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
Mark Tremblay
Richard Larouche
Nathaniel Osgood
Justin Longo
Daniel Rainham
Scott Leatherdale
Leah Ferguson
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$2,500SHRF
Description
The purpose of the PSFaM, 4th Annual Meeting, 2016, is to bring together protein scientists and structural biologists from Western Canada to present recent findings from their laboratories, to network and meet colleagues, to discuss common interests and goals, and to develop a strong, tightly knit community of protein scientists from Western Canada. Much of the presented research has been performed in part at the Canadian Light Source and the staff of the Canadian Macromolecular Crystallography Facility participates in organization of this conference. The theme of the meeting is the role of proteins in health and disease. The meeting will take place on the University of Saskatchewan Campus, Health Science Building.
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5th Western Canadian Medicinal Chemistry Workshop
Principal Investigator
Dr. Edward Krol
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
David Palmer
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$4,500SHRF
Description
The Western Canadian Medicinal Chemistry Workshop (WCMCW) was established to facilitate knowledge exchange and increase research intensity in the pharmaceutical sciences in Western Canada. The workshop also provides training and career development opportunities for postdoctoral, graduate and undergraduates researchers. The WCMCW has been held every 2 years since 2008. The 5th WCMCW will be held September 23-25, 2016 at the University of Saskatchewan. Past attendees have come from Western Canadian universities including: Calgary, Alberta, Lethbridge, Manitoba, Brandon, Winnipeg, Lakehead, UBC, Simon Fraser, Victoria, Regina and Saskatchewan.
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Molecular epidemiology and functional genomic discovery of pathogenicity factors in community-acquired MRSA in Saskatchewan First Nations communities
Principal Investigator
Mr. Keith MacKenzie
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
David Palmer
Supervisor(s)
Dr. Andrew Cameron (Lead Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
Antibiotic resistant bacteria are becoming one of the greatest health care challenges of the modern era, and they are only going to get much worse. A leading cause of antibiotic resistant infection is methicillin-resistant Staphylococcus aureus (MRSA). Although this pathogen is famous as a source of hospital-acquired infection, it is now acquired predominantly in communities. This community-acquired (CA)-MRSA is a particular health challenge in Saskatchewan First Nations communities, where infection rates are 10-times higher than comparable communities in Alberta and Manitoba. This research will address this Saskatchewan health priority using the latest DNA sequencing technology to resolve how CA-MRSA has moved and continues to move within and between communities. This epidemiological research will build on the Northern Antibiotic Resistance Partnership (NARP) and provide greater insight using the most modern DNA sequencing technologies. As well, this research will use genomic techniques to identify genes associated with severe health outcomes in Saskatchewan patients, then, study the functions of these virulence genes in the laboratory using gene expression and infection assays. This research is designed to promote proactive health care by identifying mechanisms of infection and disease transmission that can be targeted through preventive means, such as identifying reservoirs of antibiotic-resistant bacteria and blocking routes of transmission.
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Development and pilot testing of a decision aid for dementia patients in long-term care in Saskatchewan and their surrogate decision makers
Principal Investigator
Dr. Leslie Malloy-Weir
Canadian Centre for Health & Safety in Agriculture (Department of Medicine)
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
David Palmer
Supervisor(s)
Dr. Debra Morgan (Lead Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
In Canada and elsewhere, there are two overlapping trends that have major implications for the delivery of health care: 1) an increase in the prevalence of patients with dementia, and 2) increasing efforts to involve patients in decisions about their care using decision aids. Dementia patients in long-term care settings are commonly prescribed antipsychotic medications to treat aggression, delusions and agitation. The involvement of dementia patients and/or their surrogate decision makers in decisions about the use of antipsychotic medications is critical because these medications have risks (e.g. infections, falls, death) that may outweigh their benefit. This study will use a mixed-methods approach to design and test a decision aid to help dementia patients in long-term care and/or their surrogate decisions makers to: 1) learn about the benefits and risks of antipsychotic medications, and 2) decide whether or not these medications should be taken. Scientific evidence, along with feedback obtained from physicians, dementia patients in long-term care and/or their surrogate decision makers, will inform the design of the decision aid (i.e. content and mode). The effects of the decision aid on: 1) knowledge about the benefits and risks of antipsychotic medications, and 2) decision to take, or not, these medications, will be assessed using a survey and interview with dementia patients in long-term care and/or their surrogate decisions makers who were not involved in the design phase. This study will promote patient-centred dementia care and will inform efforts to implement the use of decision aids in Saskatchewan and elsewhere in Canada.
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Deciphering the mechanistic role of newly identified mitochondrial interactions in Parkinson's disease
Principal Investigator
Dr. Ramy Malty
Chemistry and Biochemistry
Science
University of Regina
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
David Palmer
Supervisor(s)
Dr. Mohan Babu (Lead Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
Mitochondrial dysfunction, oxidative stress, protein aggregation and microglial activation are key to Parkinson's disease (PD) pathogenesis. We concluded a large-scale screen to identify novel mitochondrial protein complexes associated with PD. Superoxide dismutase (SOD1)-peroxiredoxin5 (PRDX5) heterodimer and inhibitor of NF-κB (IκBε)-PINK1-PARKIN heterotrimer are novel complexes that were detected and validated.PRDX5 perturbation in differentiated SH-SY5Y cells shows reduced SOD1 activity, increased superoxide anion and increased mitochondrial depolarization, suggesting that SOD1 activity requires PRDX5. I propose that SOD1-PRDX5 interaction protects SOD1 from auto-oxidation. Using computational modelling, we determined that SOD1-E133 is critical for PRDX5 interaction. I will construct SOD1-E133 mutants and test for loss of PRDX5 interaction. SOD1-E133 mutants will be used to examine the role of SOD1-PRDX5 interaction in differentiated SH-SY5Y cells. NF-κB is activated by ubiquitination and proteasomal degradation of IκBs. Mitochondrial depolarization activates PINK1, a kinase, which activates PARKIN, a ubiquitin ligase. Mitochondrial dysfunction was shown to activate NF-κB, however, the mechanism is unknown. I propose that PINK1-PARKIN link mitochondrial dysfunction to NF-κB activation via ubiquitination and degradation of IκBε. We show that the mitochondrial toxin rotenone, increases ubiquitination of IκBε. I propose using microglial cell line to test if rotenone activates NF-κB, whether this effect is mediated by PINK1- or PARKIN-induced IκBε degradation.In both models, key findings will be verified in human induced dopaminergic neurons and microglia, respectively. These studies will expand our understanding of PD pathogenesis and shed light on new PD drug targets.
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Behavioural and neural network comorbidities of a psychiatric phenotype in a rat model of absence epilepsy: effects of the T-type calcium channel blocker Z944
Principal Investigator
Dr. Wendie Marks
Physiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
David Palmer
Supervisor(s)
Dr. John Howland (Lead Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
T-type calcium channels are implicated in the pathophysiology of complex psychiatric and neurological disorders such as absence epilepsy. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is a spontaneously occurring rodent model of absence epilepsy that displays interictal behavioural changes related to symptoms of psychiatric illness. Systemic treatment with the novel T-type calcium channel blocker, Z944, rescues the behavioural deficits observed in GAERS. To elucidate how T-type calcium channels mediate these behaviours, GAERS will be used to identify and define the neural networks that are perturbed to alter behaviour. This will be achieved in two series of studies. The first will identify the brain regions involved in mediating the effects of Z944 on two measures: visual (crossmodal) and emotional (Pavlovian fear extinction) learning and memory, by infusing Z944 into task-dependent brain areas prior to testing. The second series of studies will examine patterns of neural activity, using freely moving electrophysiology, that are associated with crossmodal and fear extinction deficits in GAERS and the impact of systemic Z944 on the synchrony of neural oscillations. Brains will be double labelled for immediate early gene activation and parvalbumin to correlate patterns of activity with alterations in interneuron network properties. The proposed experiments will be the first to link behaviour in GAERS with altered patterns of neural activity using direct recordings of brain activity and post-mortem histology techniques. Increasing our understanding of the mechanisms of cognitive impairment is expected to provide new avenues for the diagnosis, treatment and prevention of psychiatric disorders.
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Advancements in FASD Symposium: Diagnostic Training and Development of Recommendations for a Psychotropic Algorithm
Principal Investigator
Dr. Mansfield Mela
Psychiatry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
David Palmer
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$6,500SHRF
Description
We are hosting a one-day symposium on FASD and psychotropic medication which will include training workshop and an expert panel at the University of Saskatchewan. This clinical workshop will seek to accomplish 2 main goals; 1) The first is to provide a forum for training physicians to recognize and diagnose FASD according to the recently updated Canadian guidelines (published in 2015). 2) The second is to host an expert panel to generate a consensus of recommendations for developing the first-ever algorithm to assist physicians treating patients with FASD and psychotropic medications (with an end goal of producing a Cochrane review).
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Identifying and Understanding the Health and Social Care Needs of Older Adults with Multiple Chronic Conditions and their Caregivers: A Scoping Review
Principal Investigator
Dr. Debra Morgan
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
David Palmer
2016-2017 SPOR PIHCI Network - Knowledge Synthesis Grants
One year
FUNDING RECEIVED
$5,000SHRF
$25,000CIHR
$29,000Other Partners
$59,000Total
Description
Canadians are living longer, however, many older Canadians do not experience good health and wellbeing as they age. Older adults are at a high risk of having multiple chronic conditions (MCC), otherwise known as multimorbidity. Many older adults with MCC live with complex health issues that adversely affect their day-to-day functioning and overall wellbeing. As a result, they rely on the support of caregivers to complete daily activities. Caregiving for older adults, without the appropriate help, can negatively affect an individual's financial and emotional wellbeing. Currently, not enough is known about how best to identify, understand and meet the needs of older adults with MCC, or the needs of their family caregivers. This study will contribute to minimizing the existing gap in knowledge. This project will provide much needed evidence to support current efforts to improve the Canadian healthcare system and ensure that older adults with MCC, and their caregivers, receive appropriate, equitable and cost-effective health and social care. The project team is comprised of patients, their family members, researchers, healthcare providers and policy and health system administrator decision makers, from Nova Scotia, Ontario, Québec and Saskatchewan. Our research will offer an overview of the existing evidence on the health and social care needs of older adults with MCC and their caregivers, as well as evidence about how best to determine and understand these needs. Findings from our work will directly support the development and implementation of Primary & Integrated Health Care Innovations (PIHCI) tailored to meet the needs of diverse individual, and groups of, older Canadians. We take a collaborative and participatory approach to research. We aim to contribute to building a strong evidence base to support a new culture of person-centred, functioning-focused care that adds "health to years" for current and future generations of older Canadians.
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Case Management in Primary Care to Improve Outcomes Among Frequent Users of Health Care Services with Chronic Conditions: A Realist Synthesis of What Works, for Whom and in What Circumstances
Principal Investigator
Dr. Nazeem Muhajarine
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Richard Long
Co-Investigator(s)
David Palmer
2016-2017 SPOR PIHCI Network - Knowledge Synthesis Grants
One Year
FUNDING RECEIVED
$5,000SHRF
$25,000CIHR
$30,000Other Partners
$60,000Total
Description
A common reason for frequent use of health care services is the complex health care needs of individuals suffering from multiple chronic conditions, often together with mental health comorbidities and/or social vulnerability. Individuals with such complex health care needs require a variety of services across the health and social services system and the community networks. This often leads to difficulties in the integration of care. Frequent users of health care services are more at risk for incapacity, loss of quality of life and mortality. Currently it would appear case management (CM) is the most promising intervention to improve care integration for frequent users and reduce health care costs. However, important gaps in knowledge remain: we don't know how CM works, in what populations, and in what circumstances. Our overarching goal is to ensure that patients, practitioners and policy makers better understand CM for frequent users with chronic conditions, the most promising effective intervention to improve outcomes for this population with complex care needs in primary care. In order to achieve this goal, we propose to explain how CM in primary care works to improve outcomes among frequent users with chronic conditions, for whom and in what circumstances.
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Exploring Oral Health With Indigenous Communities: Collaborative Pathways for Early Intervention
Principal Investigator
Dr. Marcella Ogenchuk
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Vivian Ramsden, Rob Weiler, Holly Graham, Gerry Uswak
Co-Investigator(s)
David Palmer
2016-2017 Collaborative Innovation Development
One Year
FUNDING RECEIVED
$49,765SHRF
Description
Tooth decay is the most prevalent chronic childhood disease in Canada; Saskatchewan has the third highest rate of day surgery operations performed to treat cavities among children aged 1-5 years. Children who are treated for tooth decay in dentist's offices or clinics are not included in the above data thus underestimating the severity of the problem. Dental surgery is the most common pediatric outpatient procedure completed in Saskatoon Health Region. Despite services available, the prevalence of decay in some First Nations communities exceeds 90% - two to three times higher than non-Aboriginals and constitutes a public health crisis. Early childhood caries can have serious consequences for the functional, psychological and well-being of children. Typically, oral health falls outside the Canada Health Act thus there is considerable variation in services, continuity of programming/services, portability of benefits and oral health providers from one province or territory in First Nations communities. The oral health needs of two Indigenous communities will be explored with the communities utilizing participatory health research methodology. Specifically, the availability, accessibility, accommodation and acceptability of oral health care services will be explored along with their perceptions and health behaviours related to oral health. The knowledge gleaned by this interdisciplinary team including community members will identify strength and barriers of oral health care services to better understand oral disease, build individual, community and provincial capacity: engaging individuals, families, community leaders, health care practitioners, educators and policy makers in the building of a framework and the groundwork necessary for future funding opportunities.
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Understanding the Role of Subchondral Angiogenesis and Bone Turnover in Progression of Osteoarthritis
Principal Investigator
Dr. Arash Panahifar
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Vivian Ramsden, Rob Weiler, Holly Graham, Gerry Uswak
Co-Investigator(s)
David Palmer
Supervisor(s)
Dr. David Cooper (Lead Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
Osteoarthritis is the leading cause of long-term disability in many western societies. In a 2015 study it was estimated that 14.2% of the Canadian population are diagnosed with osteoarthritis. It is a slowly developing, multifactorial disease that is characterized by destruction of cartilage and structural damage to bone in the affected joints. Despite knowing many risk factors, the cause of osteoarthritis is not well-understood and as a result there is currently no disease-modifying drug available for its treatment.Many studies suggest that early increased turnover in bone precedes degeneration of overlying cartilage. One major hypothesis is that osteoarthritis begins by occurrence of small cracks (20-100µm length) in the calcified cartilage and subchondral bone plate (bone layer directly underneath calcified cartilage). Subsequently, one of the early structural changes in an affected joint is the increased vascular invasion from bone towards the cartilage that leads to acceleration of cartilage destruction. In order to understand the role of local angiogenesis (vascular proliferation) in progression of osteoarthritis we seek to image different stages of vascular invasion and its association with micro-cracks and cartilage integrity using synchrotron X-ray imaging. For this purpose, an X-ray contrast agent will be injected into healthy and a surgical animal model of osteoarthritis before the imaging starts. Animals will be scanned live before the surgery and at 10-day intervals for the duration of one month after the surgery to mark early pathological changes in the joint. This study will eventually help us to understand why osteoarthritis happens in human patients.
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A novel, high-resolution, in vitro technique to assess hemodynamic flow in cerebral aneurysms.
Principal Investigator
Dr. Lissa Peeling
Neurosurgery
Surgery
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Vivian Ramsden, Rob Weiler, Holly Graham, Gerry Uswak
Co-Investigator(s)
Michael Kelly
2016-2017 Establishment Grants
Three Year
FUNDING RECEIVED
$120,000SHRF
Description
Each year, 50,000 Canadians of all ages suffer a stroke, and 14,000 die, making stroke the number three killer in Canada and number one cause of long term disability. Subarachnoid hemorrhage represents a type of stroke often related to aneurysm rupture. Given the catastrophic nature of this type of stroke, it has a huge burden on society, especially since up to 5% of people may harbor an unruptured brain aneurysm. The development of innovative therapies to understand blood flow within cerebral aneurysms will reduce the overall burden of stroke on society. It is not well understood why and when some aneurysms rupture. Being able to identify higher risk aneurysms would be of tremendous value. Although there are current strategies to quantitatively and qualitatively assess flow within an aneurysm, these techniques are limited by the need for contrast agents or particles, or their poor spatial resolution. This proposal uses a novel synchrotron based imaging technique to analyze aneurysm hemodynamics within in vitro models by tracking the flow of porcine blood, utilizing the red blood cells themselves as a contrast agent. 3D patient-specific silicone aneurysm models will be used with a physiological flow pump to reproduce the pulsatile flow within the intracranial circulation. This original synchrotron imaging provides an unexplored window into aneurysm hemodynamics. Success of this project will be the foundation for a new research program at the University of Saskatchewan to study flow modeling, also to develop and evaluate therapeutic devices utilized for human aneurysm treatment.
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PET imaging GBA1 activity, a potential marker of early Parkinson's disease.
Principal Investigator
Dr. Christopher Phenix
Chemistry
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Vivian Ramsden, Rob Weiler, Holly Graham, Gerry Uswak
Co-Investigator(s)
Michael Kelly
2016-2017 Establishment Grants
Three Year
FUNDING RECEIVED
$119,900SHRF
Description
Parkinson's disease affects 7-10 million people globally with 66,000 new cases diagnosed annually in the U.S/Canada. While the incidence of Parkinson's increases with age, an estimated 4% of patients are diagnosed prior to age 50.There is currently no diagnostic test for patients that are having early Parkinson's symptoms. Instead, the diagnosis typically occurs after the occurrence of advanced clinical symptoms where an estimated 50-60% of the cells in areas of the brain important for movement control are already dead. Mutations in the gene that encodes for β-glucocerebrosidase result in a lysosomal storage disorder called Gaucher Disease. Interestingly, a strong link between Gaucher and Parkinson's disease was established leading to the discovery that mutations in the glucocerebrosidase gene are the most potent genetic risk factor for developing Parkinson's disease. This work resulted in pioneering preclinical and clinical studies that have shown a deficiency in glucocerebrosidase enzyme activity is known to occur in both early and late Parkinson's as well as sporadic Parkinson's disease patients. This project will provide all the preliminary steps towards the development of a positron emission tomography method that will be useful as a research tool to investigate the role of glucocerebrosidase in Parkinson's disease as well as guide the development of novel Parkinson's therapies. Eventually, this work could lead to a new clinical test capable of detecting early Parkinson's disease based on a deficiency in glucocerebrosidase activity prior to the onset of advanced symptoms and neuron death.
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Seventh CIHR-THRUST Retreat
Principal Investigator
Dr. Ingrid Pickering
Geological Sciences
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Vivian Ramsden, Rob Weiler, Holly Graham, Gerry Uswak
Co-Investigator(s)
Susan Nehzati
Janna Andronowski
Kelly Summers
Devin Brown
Andrew Crawford
2016-2017 Research Connections Grants
Three Year
FUNDING RECEIVED
$3,000SHRF
Description
CIHR-THRUST, the CIHR Training grant in Health Research Using Synchrotron Techniques, promotes innovative health research training using the Canadian Light Source. The keystone annual retreat continues to be a tremendous resource supporting networking amongst trainees, mentors and special guests, and features the sharing of accomplished research during the year from a diverse group of scientists including clinical and biomedical researchers, engineers, and synchrotron specialists. Around 76 invited guests are anticipated at this year's event held on November 9th in Saskatoon. This day encourages expert discussions on synchrotron-related health research as well as platform presentation and poster sessions for trainees.
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Predicting risk of disease progression in patients with chronic kidney disease in Saskatchewan
Principal Investigator
Dr. Bhanu Prasad
Nephrology
Internal Medicine
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Vivian Ramsden, Rob Weiler, Holly Graham, Gerry Uswak
Co-Investigator(s)
Navdeep Tangri
Jennifer St.Onge
Tiffany Blair
Diane Kozakewycz
Joanne Kappel
2016-2017 Targeted Collaborative Innovation Development Grant (SPOR)
Two Year
FUNDING RECEIVED
$43,076SHRF
Description
Chronic kidney disease describes the gradual loss of kidney function to kidney failure. Currently, patients with chronic kidney disease are referred to multidisciplinary clinics in Regina and Saskatoon for treatment and follow-up, with the purpose of slowing the progression of the disease. The multidisciplinary clinics include a nephrologist, dieticians, diabetes nurses, pharmacists and social workers that provide a variety of interventions to patients with complex kidney disease. However, there are no criteria to indicate which patients require the level of care that the multidisciplinary clinic provides and which patients can be appropriately managed in primary care or by a nephrologist alone. Care in the multidisciplinary setting is more expensive and can lead to unnecessary testing/interventions for patients who are unlikely to progress to end-stage renal disease. Recently, our collaborators developed a tool that accurately predicts the progression to kidney failure. The Kidney Failure Risk Equation uses demographic and routine laboratory data to predict the risk of progression to renal failure for an individual patient. The purpose of this project is to a) validate the effectiveness of this tool for a Saskatchewan population using retrospective data from all patients enrolled in the chronic kidney disease clinics in Regina and Saskatoon from 2004-2010; and b) estimate the potential savings to the health care system if low- and intermediate-risk patients are redirected to primary care or a nephrologist, respectively. This project is a collaborative effort between clinicians, researchers, policy makers and patient/family advisors in Regina and Saskatoon to ensure all patients with chronic kidney disease in Saskatchewan get the right care at the right time.
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Developing a Mobile Application to Support Healthcare Transition Success for Adolescents with Inflammatory Bowel Disease
Principal Investigator
Dr. Tracie Risling
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Noelle Rohatinsky
Co-Investigator(s)
Sharyle Fowler
Derek Risling
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$48,551SHRF
Description
The purpose of this research is to collaborate with teens and young adults living with inflammatory bowel disease (IBD), their caregivers and healthcare providers to develop and test a mobile application to support healthcare transition (HCT) success. The study will use an innovative mix of traditional data collection methods and tools commonly employed by software developers in a new approach to the development and evaluation of patient-centered technology solutions. The specific objectives of this study are to: collaborate with IBD patients, families and providers in the pilot development of a mobile application for HCT, specifically designed to their identified and prioritized needs; and employ a novel blend of tools combining well established research processes with software development best practice to create an innovative framework for the development of patient-centered technologies. The project will provide two key outcomes. First, the development of the mobile application for HCT which, once completed beta testing, will be available for pilot use and integration into further research study. Second, this study will combine traditional research measures with software development tools thereby extending the current boundaries of mixed-methods approaches. The collaborative research design of this project will unite the expertise of patients, families, healthcare providers, researchers and software development professionals to deliver a new means of support for HCT as well as adding innovative techniques to the methodological toolkit.
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Prenatal Determinants of Chronic Inflammation-Mediated Diseases
Principal Investigator
Dr. Alan Rosenberg
Rheumatology
Pediatrics
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Noelle Rohatinsky
Co-Investigator(s)
Darryl Adamko
Marta Erlandson
John Gordon
Munier Nour
Mark Inman
SALAH ALMUBARAK
Timothy Bradley
Marie-Jocelyne Martel
Roland Dyck
Adam Baxter-Jones
Noreen Agrey
Fergall Magee
Hassanali Vatanparast
Angela Bowen
Lannae Strueby
Anthony Kusali
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$50,000SHRF
Description
This project aims to improve understanding of the earliest origins of disease by investigating the effect that inflammation during pregnancy has on the development of diseases in the child after birth. In Canada and in Saskatchewan prematurity; obesity and obesity-related diseases, including diabetes and cardiovascular disease; asthma; bone and joint diseases; and nervous system disorders represent major health burdens for affected individuals, families and society. There is evidence that these diseases have their origins before the disease becomes apparent and that inflammation during pregnancy might promote occurrence of these chronic diseases later in life. In this study we will begin to identify factors in pregnant women, including blood markers and genetic characteristics, that appear when inflammation is present. Knowing when inflammation is present will allow us to then study how inflammation during pregnancy is associated with premature birth, impaired development of the nervous system, obesity, diabetes, cardiovascular disease, reduced bone quality and respiratory conditions such as asthma. Also, during this project our Saskatchewan-based team will continue to strengthen nationwide collaborations and, together with other Canadian researchers, design future, larger-scale, definitive projects to study the association of inflammation during pregnancy with maternal lifestyle factors such as nutrition, physical activity, stress, social circumstances and environmental exposures, in conjunction with certain genetic vulnerabilities.More information about inflammation during pregnancy and its influences on the occurrence of future diseases in the child will help guide health promotion and prevention strategies to ensure healthy children now and into their long-term futures.
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Interventions and Policies Influencing Primary Healthcare Professionals Managing Chronic Diseases: An Evidence Synthesis
Principal Investigator
Dr. Thomas Rotter
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Donna Goodridge
Co-Investigator(s)
Darryl Adamko
Marta Erlandson
John Gordon
Munier Nour
Mark Inman
SALAH ALMUBARAK
Timothy Bradley
Marie-Jocelyne Martel
Roland Dyck
Adam Baxter-Jones
Noreen Agrey
Fergall Magee
Hassanali Vatanparast
Angela Bowen
Lannae Strueby
Anthony Kusali
2016-2017 SPOR PIHCI Network - Knowledge Synthesis Grants
One Year
FUNDING RECEIVED
$3,750SHRF
$25,000CIHR
$22,500Other Partners
$51,250Total
Description
Approximately six in ten Canadians aged 20 years and older live with chronic diseases, which account for $93 billion/year. Despite the enormous expenditure, 12% of Canadians have reported a feeling of unsatisfied with the quality of care and availability of health care services, which varies with the type and number of chronic diseases. The growing perception of the quality gap is a major challenge for Canadian primary health care policy makers. Indeed, a patient-centered healthcare system has been shown to support health promotion, early detection and timely treatment for people living with chronic diseases.Decision-makers in several provinces, namely Quebec, Ontario and Alberta have articulated the desire to close the gaps in quality of care that impact patient outcomes and improve primary care professionals' experience by implementing the "patient-centered medical home" model. This is a family practice, defined by its patients as the place where they would feel most comfortable (most at home) to present and discuss their personal and family health and medical concerns with primary healthcare professionals. The province of Manitoba is planning to follow suit. However, it is unclear which interventions and policies are appropriate, sustainable and sufficient to fill the perceived quality gap and support practice change in primary healthcare settings. The objectives of this integrated knowledge users' need-driven evidence synthesis are to: 1) identify, classify and critically appraise interventions and policies influencing primary healthcare professionals; 2) determine their efficacy and feasibility in the primary healthcare centers (primarily managing chronic diseases); 3) assess determinants influencing magnitude of response; 4) provide evidence-based recommendations to policy-makers in the Canadian context; and 5) identify knowledge gaps for future research.
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The Patient-Provider Toolkit: Using a Community-Based Research Approach to Support HIV+ Patients Accessing Health Care
Principal Investigator
Dr. Michael Schwandt
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Donna Goodridge
Co-Investigator(s)
Sugandhi del Canto
Jann Ticknor
Patti Tait
Ryan Meili
Mary Ermine
Barb Bowditch
Nicole Burns
2016-2017 Targeted Collaborative Innovation Development Grant (SPOR)
Two Year
FUNDING RECEIVED
$74,850SHRF
Description
The HIV (Human Immunodeficiency Virus) epidemic in Saskatchewan is unique in that it involves the convergence of social, cultural, behavioural, health and institutional issues not commonly found in other Canadian provinces. This can hinder treatment and care, limiting the management of the HIV epidemic in Saskatchewan. Issues of intravenous drug use, colonized experiences (e.g. residential schools), limited resources (e.g. high rate of homelessness), co-occurring health issues (e.g. Hepatitis C, mental health challenges), and past/persistent negative experiences with healthcare staff all contribute to a lack of trust and willingness to initiate and adhere to recommended treatments. The result is an ongoing epidemic of HIV that is two to three times the national rate. Conventional approaches to addressing this problem have had minimal impact, leading to increased suffering for this patient population, the surrounding community, and an ongoing burden on healthcare systems. Using a community-based research design, the study builds on several local studies that have found health care barriers experienced by Indigenous people in Saskatchewan, including an ongoing needs assessment of health care needs of HIV+ patients in Saskatoon. We will expand the assessment to Regina and Prince Albert, to gain a fuller understanding of the barriers and supports experienced by HIV-positive people accessing health care in urban centres in Saskatchewan. We will work collaboratively with health care providers to identify gaps in health care delivery, as well as identify gaps to optimal health care interactions. Through these findings, and as directed by patient-peer members of the research team, we will develop an interactive patient-provider toolkit rooted in Indigenous, arts-based knowledge translation approaches.
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Sustain the Gains: Sustainability in Global Health
Principal Investigator
Dr. Michael Schwandt
Community Health & Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Donna Goodridge
Co-Investigator(s)
Sugandhi del Canto
Jann Ticknor
Patti Tait
Ryan Meili
Mary Ermine
Barb Bowditch
Nicole Burns
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$5,000SHRF
Description
The 5th Annual Global Health Conference (September 30 - October 1, 2016 at Edwards School of Business) aims to bring together an interdisciplinary audience of approx. 200 students, faculty, and community members around the theme of sustainability in global health, inspired by the Sustainable Development Goals set by the United Nations in 2015. The conference will provide an opportunity for participants to explore pressing global health issues through presentations and panel discussions by leading global health experts, and hopes to inspire participants to work collaboratively across local and global boundaries. We expect the participants to come away from the conference better informed about health inequities, its causes and negative impacts and motivated to work toward approaches, practices and policies that will lead to health and social equity and justice for all.
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3D Multiple Object Tracking Training in Persons with Multiple Sclerosis
Principal Investigator
Dr. Jennifer St.Onge
Research and Performance Support
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Donna Goodridge
Co-Investigator(s)
vinesh pillay
Anthony Feinstein
Abdulhakim Raghig
Sebastian Harenberg
Kim Dorsch
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$45,795SHRF
Description
Saskatchewan has one of the highest rates of multiple sclerosis in the world. Cognitive impairments (e.g. attention, memory) occur in about 45-60% of persons with multiple sclerosis (pwMS) and negatively impacts activities of daily life, such as driving, working and social activities. There are few treatments or rehabilitation strategies available for pwMS and many cognitive rehabilitation programs are time consuming, difficult to administer and have not been linked to activities of daily life. Computerized three-dimensional multiple object tracking (3DMOT) is a novel technology designed to improve attention and processing speed, which are the functions most impaired in pwMS. Importantly, improvements observed in older healthy adults after 3DMOT have been linked to navigating in crowds and traffic. The technology is portable and very easy-to-use; however, it has never been tested in pwMS. The purpose of this study is to examine whether pwMS show improvements after 3DMOT training to the same extent as healthy people and whether these changes are associated with improvements on standardized measures of cognitive function specifically designed for pwMS. This pilot study will be the first to examine the effectiveness of 3DMOT training in pwMS. Future research will build upon this foundation to determine the real-world applicability of 3DMOT training for pwMS. Our collaboration between neurologists, academic experts in 3DMOT and cognitive impairment in pwMS, rehabilitation clinicians and staff, and the MS community will ensure that the findings are disseminated directly to knowledge users, pwMS and their families and to the broader research and clinical community.
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Knowledge Translation Seminar in Heart Failure Pathophysiology and Rehabilitation
Principal Investigator
Dr. Corey Tomczak
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Donna Goodridge
Co-Investigator(s)
vinesh pillay
Anthony Feinstein
Abdulhakim Raghig
Sebastian Harenberg
Kim Dorsch
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$1,100SHRF
Description
Heart failure is a complex syndrome that can benefit from exercise-based rehabilitation. However, a majority of individuals with heart failure do not participate in cardiac rehabilitation. We propose a knowledge translation "lunch & learn" seminar to be held at the College of Kinesiology on June 27, 2016 with the purpose of highlighting our current understanding about the pathophysiology of exercise intolerance in heart failure and the role cardiac rehabilitation. Attendees can register by email and will include an audience of researchers, physicians, clinical and research trainees, cardiac nurses, exercise therapists, and chronic disease management managers. Following will include planned meetings and discussions with targeted individuals in health care and research.
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Development of Protein Inhibitors Targeting SREBP1 for Targeted Therapy of Glioblastoma
Principal Investigator
Dr. Maruti Uppalapati
Pathology and Laboratory Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Changiz Taghibiglou
Co-Investigator(s)
Neal Lemon
Vijayananda Kundapur
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$50,000SHRF
Description
Glioblastoma multiforme (GBM) is the most aggressive and common type of malignant primary brain tumor which has a high fatality rate and no known cure. New targeted therapies are much needed, to improve prognosis and survival of patients. Here we propose to target SREBP1, a transcription factor that is up-regulated in many cancers and is the main regulator of genes involved in lipid metabolism. Given that actively proliferating cancer cells are addicted to high SREBP1 activity for nutrient supply, inhibition of SREBP1 has been showing promising results in killing cancer cells. Experimental drugs targeting SREBP1 have been developed, but the indirect mechanism of action for these inhibitors can lead to unwanted side-effects. Here we propose developing protein-based inhibitors that bind to SREBP1 and prevent protein-interactions that are necessary for its function. We will then screen these binders for their ability to disrupt SREBP1 activation using cell-based screens. The lead molecules will then be tested by their ability to specifically kill cancer cells while sparing normal cells. The proposed work is novel and has the potential to lead to better drugs for treating GBM, thereby improving patient prognosis and quality of life. Upon successful completion of this study, we will take the lead molecules from this study and utilize them as epitope guides to identify small molecule drugs with similar potency. Given that this is a priority area of research for CIHR, promising preliminary data will lead to successful funding applications for further development.
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Research Showcase 2017
Principal Investigator
Mrs. Megan Vanstone
Research and Performance Support
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Changiz Taghibiglou
Co-Investigator(s)
Neal Lemon
Vijayananda Kundapur
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$5,000SHRF
Description
Research Showcase is an annual research sharing and networking event, hosted by the Research and Performance Support Department of the Regina Qu'Appelle Health Region (RQHR). Every year, this event draws together a diverse gathering of participants including health and science researchers, policy makers, clinicians, physicians, students, and the general public in order to highlight research conducted within the region over the past year. The relevance of the event and engaging discussions surrounding the application of research into practice and policy draws an increasing number of participants every year. This year Research Showcase will take place on June 21st at Delta Hotels Regina.
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Research Showcase 2016
Principal Investigator
Mrs. Megan Vanstone
Research and Performance Support
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Changiz Taghibiglou
Co-Investigator(s)
Neal Lemon
Vijayananda Kundapur
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$5,000SHRF
Description
Research Showcase is an annual research sharing and networking event, hosted by the Research and Performance Support Department of the Regina Qu'Appelle Health Region (RQHR). Every year, this event draws together a diverse gathering of participants including health and science researchers, policy makers, clinicians, physicians, students, and the general public in order to highlight research conducted within the region over the past year. The relevance of the event and engaging discussions surrounding the application of research into practice and policy draws an increasing number of participants every year. This year Research Showcase will take place on June 20th at the Delta Regina Hotel.
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Saskatchewan Cancer Research Conference
Principal Investigator
Dr. Franco Vizeacoumar
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Changiz Taghibiglou
Co-Investigator(s)
Keith Bonham
Kiven (Erique) Lukong
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$3,000SHRF
Description
The 3rd Annual Saskatchewan Cancer Research Conference will be held at the University of Saskatchewan's Health Sciencebuilding on June 22nd 2016. For the past two years over 100 scientists attended this SHRF funded event. The conference goals are to bring together the provinces cancer researchers to foster communication and collaborations, with a special interest in translational research. This year the conference will feature keynote lecture from Dr. Shoukhat Dedhar from the BC Cancer Agency. In addition to local speakers, students and other trainees will present their work in an extended poster session.
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Saskatchewan Cancer Research Conference
Principal Investigator
Dr. Franco Vizeacoumar
Oncology
Division of Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Changiz Taghibiglou
Co-Investigator(s)
Keith Bonham
Kiven (Erique) Lukong
2016-2017 Research Connections Grants
Two Year
FUNDING RECEIVED
$3,000SHRF
Description
The 4th Annual Saskatchewan Cancer Research Conference will be held at the University of Saskatchewan's Health Sciencebuilding on June 14th 2017. For the past three years over 100 scientists attended this SHRF funded event. The conference goalsare to bring together the provinces cancer researchers to foster communication and collaborations, with a special interest intranslational research. This year the conference will feature keynote lecture from Dr. Paul Rennie from the Vancouver Prostate Centre. In addition to local speakers, students and other trainees will present their work in an extended poster session.Registration and attendance is free and available on-line http://homepage.usask.ca/~frv603/scrc.html
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Improving Emergency Department Care Provider and Patient Outcomes Using a Synergy Tool
Principal Investigator
Dr. Joan Wagner
Nursing
University of Regina
Co-Principal Investigator(s)
Lois Berry, Sonia Udod
Co-Investigator(s)
Amber Alecxe
Glen Perchie
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$28,456SHRF
Description
The synergy tool has never been used in an emergency department (ED) context due to high patient volumes. The Saskatchewan government, the Regina Qu'Appelle Region (RQHR) and Saskatchewan Union of Nurses (SUN) have priority goals to reduce ED wait times and improve patient flow while optimizing the use of nurses and enhancing quality, safe care delivery. This "real-time" staffing tool is needed to prioritize patient needs and determine a 'fit' between patient needs and ED staff (i.e. numbers, types of staff). The synergy tool, developed by an expert panel of nurses from the American Association of Critical Care Nurses, is a valid, reliable tool that has been used in acute care settings in the United States, British Columbia and Ontario. Executive and clinical leadership at RQHR are working with their information technology (IT) department to incorporate patient synergy scores into the electronic health record (EHR). The EHR is also used by nurses to chart patient progress and status. The purpose of this study is to determine whether innovative use of EHR, combined with the synergy tool, will better inform ED patient care delivery and nurse workload management within RQHR. A ground-breaking partnership has been established with researchers, RQHR and SUN to evaluate data from ED patient synergy scores, patient outcomes and nurse utilization. The accurate assessment and feedback to decision makers regarding this first-time use of IT and a "real-time" staffing tool may lead the way for EDs across Saskatchewan to enhance work environments and improve patient care.
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Chronic in vivo study of lanthanide compounds in an osteoporosis model (OVX rat) for the treatment of bone density disorders
Principal Investigator
Dr. Kishor Wasan
Division of Pharmacy
Pharmacy and Nutrition
University of Saskachewan
Co-Principal Investigator(s)
Lois Berry, Sonia Udod
Co-Investigator(s)
David Cooper
Ellen Wasan
Jacqueline Cawthray
Chris Orvig
2016-2017 Establishment Grants
Three Year
FUNDING RECEIVED
$119,856SHRF
Description
Bisphosphonates are commonly used to treat bone density disorders, such as osteoporosis, however they suffer from several disadvantages. They exhibit poor solubility which contributes to low oral absorption (<1%). The guidelines for oral administration require fasting before and patients must not lie down for 30 minutes following administration. Such strict guidelines lead to poor patient compliance and lower treatment efficacy. There are also health risks associated with prolonged use. Importantly, bisphosphonates and newer treatments only target one aspect of the bone remodelling cycle; bone resorption. As the Canadian population ages, more, and better, drugs for osteoporosis are required.Our hypothesis is that lanthanum compounds with designed ligands have potential as therapeutic agents for bone disorders in which the bone remodeling cycle is disrupted. Lanthanum, La3+, shares many similar properties with calcium including a high affinity for bone. La3+ is known to affect both aspects of the bone remodelling cycle: stimulate bone formation and inhibit bone resorption.In preliminary published (Chem. Sci. 2015, Dalton Trans. 2013, Dalton Trans. 2007) and unpublished work, we identified two promising La3+-containing compounds that are targeted to bone, (La(dpp)3 and La(XT)) based on in vitro and cell studies as well as acute (1 month) animal studies. This proposal concerns testing these lead compounds in an oral chronic (6-month) study using an osteoporosis (OVX rat) model. The uptake of lanthanum on bone, their biodistribution and toxicity will be assessed. The effect of these compounds on bone architecture and possible mechanisms of action will also be assessed.
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Epidemiology for Understanding our Changing World
Principal Investigator
Dr. Brandace Winquist
Performance and Quality Management
Cypress Regional Health Authority
Co-Principal Investigator(s)
Lois Berry, Sonia Udod
Co-Investigator(s)
Silvia Bermedo-Carrasco
2016-2017 Research Connections Grants
Three Year
FUNDING RECEIVED
$3,250SHRF
Description
Epidemiology for understanding our changing worldOur environments (global, local, social and physical) are ever-changing, prompting us to reflect on the way we practice epidemiology, the kinds of questions we ask, and the methods we use to answer them (Neil Pearce, Int J Epidemiol, 2010). New challenges will require new ways of thinking about problems, working together across disciplines, and innovative ways of applying health informatics.Symposium date: Nov 2, 2016 Workshop date: Nov 3, 2016 Location: Marquis Hall, University of Saskatchewan, 67 Campus Drive Saskatoon SK S7N 4L3 Expected attendees: 90 (symposium), 25 (workshop) Registration: https://www.picatic.com/SEA2016
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A Combined Bio-Statistical and Behavioral Approach to Understanding Outcomes in Patients Living with HIV in Saskatchewan
Principal Investigator
Dr. Alexander Wong
Infectious Disease Clinic
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Lois Berry, Sonia Udod
Co-Investigator(s)
Jeffrey Joy
Maurice Hennink
Cindy Feng
Richard Harrigan
Nathaniel Osgood
Julie Reed
Dominik Werber
Debbie Rodger
Tania Diener
Holly Graham
2016-2017 Targeted Collaborative Innovation Development Grant (SPOR)
Two Year
FUNDING RECEIVED
$73,182SHRF
Description
Saskatchewan currently faces a unique HIV epidemic driven primarily by injection drug use with disproportionate representation of Indigenous peoples. HIV incidence rates in Saskatchewan are nearly double the Canadian average. Limited evidence is available to identify optimal approaches to improve clinical outcomes for those living with HIV and reduce the number of new infections. Our key research questions include:1. Which patient characteristics predict poor clinical outcomes and failure to achieve HIV viral suppression?2. Is it feasible to capture data to understand behavioural patterns in HIV-infected individuals using innovative mobile technology which can in turn help predict clinical outcomes?The study has two distinct components; the use of retrospective data of persons diagnosed with HIV attending the Regina Qu'Appelle Health Region's Infectious Disease Clinic to determine the patient factors which predict engagement, retention in care, medication use and viral suppression; and an innovative pilot analysis utilizing the Ethica iEpi platform, a health monitoring application, developed in Saskatchewan, designed to run in the background of smartphones. iEpi allows for individualized data collection through detailed sensor-level data, participant-triggered self-reporting via questionnaires and submission of photos and audio recordings by the user.Many persons living with HIV in Saskatchewan struggle with complex social and medical challenges, and account for very high rates of utilization of health care resources in community and in acute care settings. By understanding which clinical interventions are most likely to improve retention in care and viral suppression, provincial incidence rates of HIV will decline and downstream pressures on health care resources will improve.
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Targeting HAGE (DDX43) Helicase in Acute Myeloid Leukemia
Principal Investigator
Dr. Yuliang Wu
Cancer Cluster
Biochemistry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. John DeCoteau
Co-Investigator(s)
Jim Xiang
Miroslaw Cygler
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$50,000SHRF
Description
Acute myeloid leukemia (AML) is the most common and aggressive form of adult acute leukemia, accounting for approximately 30% of leukemias and more than 40% of leukemia-related deaths. The clinical outcome of AML is poor, with an overall five-year survival rate of about 25% that greatly depends on the patient's ability to tolerate the combination of cytotoxic chemotherapies that suppress much-needed haemopoiesis. Therefore, there is an urgent need for innovative therapies directed against relevant biological targets in AML to improve clinical outcomes. HAGE, helicase antigen gene, first identified in a sarcoma cell line, encodes a member of the DEAD-box family of ATP-dependent RNA helicases, also known as DDX43. HAGE is expressed in many hematological and solid tumours but not in any normal tissues, except the testis. Thus, HAGE is proposed to be a valid candidate for designing vaccines and drugs against cancer. In this team project, we will first determine the efficacy of HAGE as a potential biomarker of AML using cultured AML cells and AML patient samples. Second, we will identify drugs that inhibit HAGE protein enzymatic activity. Last, we will determine the effect of identified drugs on AML patient cells and in an AML mouse model. We expect to confirm that the over-expression of HAGE is a biomarker of AML and identify potential drugs that inhibit HAGE's activity and may specifically kill AML cells. Such initial results would lead to requests for subsequent funding from the Leukemia and Lymphoma Society of Canada, the Canadian Cancer Society and CIHR.
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Beneficial Cytotoxic T Lymphocyte Responses Derived from Irreversible Electroporation (IRE-NanoKnife) of Pancreatic Cancer for Improvement of IRE-Ablation Cancer Therapy
Principal Investigator
Dr. Jim Xiang
Cancer Cluster
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. John DeCoteau
Co-Investigator(s)
Michael Moser
Wen Jun (Chris) Zhang
Rajni Chibbar
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$50,000SHRF
Description
Irreversible electroporation (IRE) is a relatively new technology that destroys tumors and has been used in over 500 cases in the United States. Saskatoon is only the second centre in Canada to have a clinical IRE program, which just started in 2015. What is unique about IRE is that, compared to other technologies which destroy tumours by the insertion of probes into the tumor and ‘burning’ the tumour, IRE generates no heat. The current "punches" tiny holes in cancer cells and is very effective at tumour cell killing with no heat and minimal collateral damage.Studies have shown that IRE has improved the overall outcome for pancreatic cancer for the first time in 40 years. The fact that cells are not "melted" by this technology leads us to hypothesize that the dead but non-melted cells can be targets for the immune system to "learn" how to seek and destroy cancer cells within the initial tumor, and also against cancer cells that have spread elsewhere (metastasis). Saskatoon is fortunate to have strong collaborations between a cancer immunity specialist, pancreatic cancer surgeons and biomedical engineers to work together on answering this question and to look at ways of increasing that immune response.
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Shaken, and Stirred: Exploring the Bonds Between Whole Body Vibration and Human Performance
Principal Investigator
Dr. Marcus Yung
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. John DeCoteau
Co-Investigator(s)
Michael Moser
Wen Jun (Chris) Zhang
Rajni Chibbar
Supervisor(s)
Dr. Catherine Trask (Lead Supervisor) Dr. Stephan Milosavljevic (Supervisor)
2016-2017 Postdoctoral Research Fellowships
Two Year
FUNDING RECEIVED
$100,000SHRF
Description
Saskatchewan's agricultural, mining, construction and transportation workers commonly experience physical shaking, jarring and sudden movements as part of their work. Such exposure to whole body vibration (WBV) is a risk factor for many chronic health conditions including low back pain, musculoskeletal issues, balance disturbances, digestion problems and prostate disorders. WBV may also negatively affect performance, which can lead to fatal and non-fatal occupational injuries and accidents, including equipment-related injuries, falls and vehicle collisions. For instance, 10.7% of all workers compensation time-loss claims were from vehicle-related injuries. Current WBV exposure guidelines were designed to prevent long-term musculoskeletal disorders and discomfort. It is uncertain whether these standards protect workers from short-term effects. This research evaluates the effects of current WBV standards on short-term human performance. In a laboratory setting, 16 healthy adult participants will be exposed to 30 minutes of simulated WBV at two constant vibration intensities (based on standard guideline thresholds) plus a control condition with no vibration exposure. A fourth condition will consist of vibration combined with short, high-amplitude mechanical shocks associated with excessive speed, uneven terrain and obstacles common in occupational work. Before and after each condition, we will measure cognitive, sensory, motor control, biomechanical and physiological performance effects. By exploring the relationships between WBV and various aspects of performance, we will clarify the suitability of current WBV guidelines to lessen short-term effects, and contribute to the development of recommendations that will improve working conditions for a safer and healthier Saskatchewan.
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Dust Exposure Reduction for Workers: Airborne Dust Removal in Poultry Houses by Electrostatic Space Charge System (ESCS)
Principal Investigator
Dr. Lifeng Zhang
Chemical and Biological Engineering
Engineering
University of Saskatchewan
Co-Principal Investigator(s)
Dr. John DeCoteau
Co-Investigator(s)
Shelley Kirychuk
Huiqing Guo
Christina Nelson
2016-2017 Collaborative Innovation Development
Two Year
FUNDING RECEIVED
$47,000SHRF
Description
Modern methods of poultry facility management require that workers spend a large proportion of the day in an atmosphere containing comparatively high levels of dust, endotoxin, gases and odors. Recent studies conducted among Saskatchewan poultry workers showed that after long-term exposure in the contaminated atmosphere, poultry workers have the greatest prevalence of lower air ways respiratory symptoms, upper respiratory symptoms and chronic bronchitis compared to workers from other agriculture industries. This research project will aim to demonstrate the efficiency of airborne dust removal by an electrostatic precipitator-based technique. As a result, improved air quality will considerably benefit workers and birds in both short and long terms. Additionally, emissions of hazardous particulate matter from poultry facilities will be subsequently reduced, posing fewer threats to public health.This project aims to develop an advanced dust removal technique suitable for dust-laden poultry houses and conduct preliminary testing of its impact on improving air quality. The preliminary results from this project will position the team well to obtain more funding to optimize and scale-up the design and monitor health of workers to demonstrate efficacy of the technology for reducing respiratory symptoms and/or illness. The long-term goal is to identify and recommend suitable exposure limits for reducing negative effects on exposed workers in the poultry industry in Saskatchewan while simultaneously offering a technologically viable solution to meeting those targets. In a broader spectrum, the results can be extended to other confined animal facilities where particulate matter is a potential hazard to the health of exposed workers.
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Identification of New Biomarkers for Breast Cancer
Principal Investigator
Dr. Deborah Anderson
Cancer Research & Saskatchewan Cancer Agency
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. John DeCoteau
Co-Investigator(s)
Pamela Meiers
Lynn Dwernychuk
Scott Napper
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Breast cancer affects 1 in 9 women in Canada. Whereas imaging (i.e. mammography) has allowed for earlier detection of breast cancer and a reduction in the mortality rate, the participation rate in screening programs is consistently <50% of eligible women (ages 50-69). There are also significant challenges to providing screening services to a disperse population (i.e. rural Saskatchewan) and to methods that some consider quite invasive. This project will use a new innovative technology to determine if a blood test can be used to screen for breast cancer. Two groups of women will be invited to participate in this study, healthy women and women with a breast lump (of which ~60% will have breast cancer), prior to any surgery to remove the lump. Immune cells will be isolated and tested for the activation of several hundred protein kinases. To reduce the variability in the samples, we will focus on post-menopausal women that do not have any known infections or autoimmune conditions. Our team consists of clinicians/end users that see patients with breast lumps, a clinical trials specialist, cell biologist and immune/kinase specialist. Success in this pilot study will be followed up with an application to the Canadian Breast Cancer Foundation. In this subsequent study we will expand the sample size and compare the accuracy of this test to existing screening. We will also focus on making the analysis more feasible for translation from the broad and expensive analysis used in a research setting (hundreds of kinases), to a more focused (likely 10-20 signature kinases) and economical analysis better suited for a clinical laboratory setting. We expect that there are a subset of kinases that are consistently activated or inactivated in participants with breast cancer, as compared to those with benign breast lumps (no cancer) and healthy women. Our goal is to develop a blood test for the identification of women with breast cancer in Saskatchewan, Canada and globally.
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Does Fall Arrest Strategy Training (FAST) Added to a Fall Prevention Program Improve PhysicalCapacity to Prevent Serious Fall-related Injury in Women?
Principal Investigator
Dr. Catherine Arnold
Physical Therapy
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Jonathan Farthing
Jo Ann Walker Johnston
Soo Kim
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,763SHRF
Description
Falls are the leading cause of injury hospitalization for seniors across Saskatchewan and addressing the underlying causes is a provincial health priority. Older women are more vulnerable to the most common fall-related injuries (upper body) during forward falling while walking. Exercise programs designed to improve balance and strength can reduce fall risk but it is not known if specific exercises targeted to upper body strength and agility can improve chances for safe landing when a fall is inevitable. This research team has developed such a program, Fall Arrest Strategy Training (FAST) and successfully piloted the exercises in Staying on Your Feet, an established Saskatoon Health Region fall prevention program. FAST is meant to increase arm strength, reaction time, trunk control and teach better landing techniques. The potential efficacy of such an intervention to improve landing capacity has not been studied in older women. Thirty-two women age 60 years or older will be randomly assigned to either FAST or a Standard Exercise group. Half will do standard exercises targeting balance, mobility and lower extremity strength; the other half will do the same exercises with the addition of FAST. Both groups will exercise twice per week for 12 weeks. Participants will be tested before and after for arm strength, reaction time, balance, mobility and the ability to control body descent (absorb energy) using a technique we developed in our lab. While in a safety harness, they will simulate a forward fall onto a platform that measures energy during impact. While completely preventing falls is not possible, this study will help us learn if simple exercises like FAST combined with balance training can decrease fall risk AND reduce the risk of serious injury when a fall is unavoidable. It will help address the growing personal and societal cost of fall-related injury. This study will also inform future research targeted to include a large-scale trial evaluating the impact and implementation of FAST training in older adults across the spectrum of care and development of a computer simulation model to determine which factors are most important for reducing the risk of fall-related injury.
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Chronic Pain Network
Principal Investigator
Dr. Krista Baerg
Pediatrics
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Jonathan Farthing
Jo Ann Walker Johnston
Soo Kim
2015-2016 Strategy for Patient-Oriented Research Networks in Chronic Disease
Five Year
FUNDING RECEIVED
$125,000SHRF
Description
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Evaluating a Theory-Based Hope Intervention to Support Parents of Children with Life Limiting and Life Threatening Illnesses
Principal Investigator
Dr. Jill Bally
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Chris Mpofu
Lorraine Holtslander
Heather Hodgson-Viden
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$119,999SHRF
Description
Having a child diagnosed with a life limiting (LLI) or life threatening illness (LTI) is a shocking and devastating experience for a parent, made worse by repeated periods of uncertainty, loss of control, and distress. Hope has been described by parents as ‘the calm in the storm', and a critical and essential aspect of their health and caregiving activities. Thus, keeping their hope possible is an important part of providing optimal and total health care for families. However, parents are at risk for losing hope. There is little scientific information available to support health care providers in assessing and intervening successfully to promote and maintain all aspects of parents' health when undergoing the very difficult transitions related to their child's illness. Similarly, there are very few supportive interventions to improve holistic health care and positive health outcomes for families who have children with LLIs and LTIs. The purpose of this two-phased, quasi-experimental, mixed methods study is to: a) refine and pre-test the acceptability and feasibility of a theory-based hope intervention for parents who have children with LLIs or LTIs and b) evaluate the effectiveness of the revised intervention. This collaborative research will help to provide better comprehensive supportive care for families. The findings from this study will also establish a foundation for future research aimed at improving pediatric family care.
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Getting to the source of inter-regional variation in patient flow performance: A complex systems perspective
Principal Investigator
Dr. Jenny Basran
Division of Geriatric Medicine
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Chris Mpofu
Lorraine Holtslander
Heather Hodgson-Viden
2015-2016 Partnerships for Health System Improvement (PHSI)
Three year
FUNDING RECEIVED
$80,000SHRF
$400,000CIHR
$480,000Total
Description
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Saskatchewan Cancer Research Conference
Principal Investigator
Dr. Keith Bonham
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Franco Vizeacoumar
2015-2016 Research Connections Grants
Three year
FUNDING RECEIVED
$3,000SHRF
Description
The 2nd Annual Saskatchewan Cancer Research Conference will be held at the University of Saskatchewan's Health Science building on June 25th 2015. The conference will bring together the provinces cancer researchers to foster communication and collaborations, with a special interest in translational research. This year the conference will feature two keynote speakers, Dr. Lynne-Marie Postovit from the University of Alberta and Dr. Cheryl Helgason from the BC Cancer Agency. In addition to local speakers, students and other trainees will present their work in an extended poster session.
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Analysis of pharmacological targets in acute and chronic spinal cord injury
Principal Investigator
Dr. Josef Buttigieg
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Mohan Babu
2015-2016 Spinal Cord Injury Research Grants
Two year
FUNDING RECEIVED
$69,000SHRF
Description
Spinal cord injury (SCI) causes devastating impairment. Current therapies for SCI are limited and more effective treatments are required. Following the initial mechanical injury there is massive loss of neurons and supportive cells due to a substantial increase in calcium inside the cell and can spread from cell to cell in an uncontrolled manner. At the moment we are developing a novel pharmatherapeutic in the treatment of the acutely injured spinal cord (recent injury). By modulation of certain classes of potassium channels, we were able to reduce acute SCI severity. What is not known is whether other classes of proteins are able to better improve motor function or restore damaged tissue in chronically injured spinal cords (long-term injury) or promote regeneration. Some of our initial work indicates that there are several proteins that may fit this category. Here, we propose to utilize proteomic analysis of the chronically injured spinal cord. In proteomics we are able to map the interaction of thousands of proteins simultaneously to identify potential targets. These in turn can be analyzed in a rodent model of moderate SCI that we currently employ at the University of Regina. The targets of interest include mitochondrial membrane proteins involved in reactive oxygen species generation, surface membrane proteins involved in regulating calcium influx. Lastly we will also be investigating the migration and activity of endogenous stem cells. These experiments, in a clinically relevant rodent model of SCI, are critical to translating this promising treatment strategy into the clinic.
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Canadian Society of Microbiologists 2015 conference
Principal Investigator
Dr. Andrew Cameron
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Paul Levett
Aaron White
2015-2016 Research Connections Grants
Two year
FUNDING RECEIVED
$10,000SHRF
Description
The University of Regina is hosting the 2015 meeting of the Canadian Society of Microbiologists (CSM), a non-profit organization of 450 members from academic and government laboratories. The 2015 meeting has a large emphasis on infectious disease, with a focus on challenges facing Saskatchewan and its aboriginal communities, including tuberculosis, antibiotic resistance, and waterborne diseases. The CSM attracts around 250 scientists, and speakers include scientists from the Saskatchewan Disease Control Laboratory, the Vaccine and Infectious Disease Organization, First Nations University, local health authorities, and Canada's National Microbiology Laboratory. Thus CSM 2015 will bring together Saskatchewan infectious disease specialists with conferees from across Canada, the US, and Europe.
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A prospective assessment of PTSD symptoms using analogue trauma training with nursing students
Principal Investigator
Dr. Nicholas Carleton
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Florence Luhanga
Jaime Mantesso
Kish Lyster
Joan Wagner
Samantha Horswill
Sebastian Harenberg
Michelle McCarron
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,959SHRF
Description
Post-traumatic stress disorder (PTSD) can be the result of exposure to traumatic events and involves several clusters of symptoms including intrusive thoughts, avoidant behaviours, negative changes in mood, and symptoms of anxiety, such as hyperarousal. PTSD is associated with substance abuse, pain, interpersonal issues, and suicide. People exposed more frequently to traumatic events (e.g., nurses, paramedics, police) are more likely to develop PTSD as a function of that exposure. Despite the high personal and societal costs of PTSD, studying PTSD experimentally is challenging unless people are assessed before and after exposure to traumatic events. Ethical and practical concerns about such research designs have slowed PTSD research; however, several populations engage in advanced, realistic training scenarios that could serve as very valid approximations of trauma and, therein, facilitate research to reduce PTSD. Realistic training scenarios are resource-intensive; as such, a preliminary pilot study is required before investing in a full-scale research project using such scenarios. The faculty and students at the University of Regina will make conducting a pilot very achievable. A sample of nursing students will be assessed for psychosocial factors thought to increase or decrease the risk for PTSD symptoms. Each student will then proceed through a challenging high fidelity disaster-training triage scenario designed to be stressful. The students' self-reported symptoms and self-care behaviours before, during, immediately after, and in the few weeks that follow can help to narrow psychosocial factors that predict problematic symptoms after a stressful experience; thereafter, the study provides a critical proof-of-concept for acquiring larger funding from the Canadian Institutes of Health Research to study larger and more diverse samples. In addition, even the preliminary data will help to narrow psychosocial factors that predict problematic symptoms after a stressful experience. Results from this line of research would provide critical information to inform policies and procedures for reducing the risk of developing PTSD, identifying those who may need help early, and improving the quality of treatments. In the interim, this exciting pilot project will provide an important training opportunity for nursing and psychology students, and facilitate the acquisition of much needed funding for PTSD research.
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Impact of Pro-inflammatory Blood-born Intruders on Neuronal Survival in Animal Stroke Models
Principal Investigator
Dr. Francisco Cayabyab
Surgery
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Lixin Liu
Michael Kelly
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
It is increasingly recognized that in acute ischemic stroke, some blood cellular components, including lymphocytes, macrophages and neutrophils, infiltrate the brain parenchyma, thereby contributing to excessive inflammatory processes and neuronal damage. We have recently shown in animal studies that these cells accumulate in the cerebral cortex after an in vivo focal cortical ischemia stroke model. The research objective includes determining whether the leukocyte-specific protein 1 (LSP1) is an important molecular switch inside endothelial cells lining the blood vessel wall, which regulates entry of intruding leukocytes into the brain to increase stroke damage in highly susceptible brain areas, such as the hippocampus (the memory-forming center in the brain); and determining whether G31P peptide and anti-alpha4 integrin therapy, both of which attenuate leukocyte chemotaxis and recruitment, respectively, can prevent hippocampal neurodegeneration. These related aims will further clarify the properties and roles of the specialized endothelial wall lining of intracranial vessels in stroke damage. We predict that the loss of LSP1 or inhibition of leukocyte recruitment by G31P peptide and anti-alpha4 integrin therapy will produce less inflammatory response and hence less neuronal damage after stroke. We will use transgenic animals along with biochemical, electrophysiological, confocal immunofluorescence microscopy imaging, and behavioural assays that are already established in our labs. Overall, this research aims to determine whether minimizing the hyper-inflammatory damage caused by activated peripheral immune cells and their secreted factors could be a viable way to reduce neurodegeneration and cognitive and other behavioural deficits after stroke injury. The results will greatly impact the aging demographics, as excessive inflammation is involved in silent strokes and vascular dementia - two aging-related neurological diseases prevalent in Saskatchewan.
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Perspectives on Furthering Synchrotron Research in the Biological and Life Sciences
Principal Investigator
Dr. Dean Chapman
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Ingrid Pickering
Michael Pushie
Isaac Pratt
2015-2016 Research Connections Grants
One year
FUNDING RECEIVED
$7,000SHRF
Description
Alongside the annual meeting, we are hosting a biological and life sciences focused workshop. We will focus on a broad range of topics of relevance, including neuroscience, bone, vascular and pulmonary, metals in life, and cancer. We will also focus on how synchrotron science can contribute to these fields. This day long workshop addresses the current state of the art, where this area may head in the next 5 years, here and elsewhere, and finally what the future may hold. The workshop will produce a report that CLS management will use to identify key infrastructure needs and research opportunities, determine strategic goals, and develop funding strategies for operations and new initiatives. The strength of this workshop is that it engages trainees (i.e., graduate students and post-doctoral fellows) as leaders in both the organization and operation of the workshop. They represent the future of research and will have a key role to play in helping to define that future.
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Exploring the intersections of leadership, interdisciplinary teams, and patient engagement processes in Home First: A Case Study.
Principal Investigator
Dr. Roslyn Compton
Nursing
Saskatchewan Polytechnic - Saskatoon
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Donna Goodridge
Susan Sommerfeldt
Vera Caine
donna jouan-tapp
Brenda Rossow-Kimball
Charlotte Berendonk
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$20,000SHRF
$20,000Technology Evaluation in the Elderly Network (TVN)
$40,000Total
Description
With the first baby boomers reaching the age of 65 in 2011, the older adult population is growing exponentially, making it necessary to better understand what is needed to allow older adults to age-in-places of their choice. Aging-in-place refers to people being able to remain in their home, even though they may require increasing support. Home First is an innovative, quick response team in Saskatoon with the goal to change the path of long-term care placements for older adults living with significant acute or chronic health challenges. The Saskatoon Council for Aging identified that many seniors prefer to age in their own home, yet in face of acute incidences older adults are often confronted with difficult decisions about where to reside. Home First shows success in both decreasing hospital readmissions and visits to emergency room departments. A unique opportunity exists to explore the intersections of leadership, interdisciplinary teams and patient engagement in Home First. These areas were identified in a previous interpretive descriptive study as key in the program's acceptance and uptake in the client and caregiver population. Using a case study approach, the focus will be on making innovative and new inferences between processes and outcomes within a ‘real world' or natural context. Patient complexity and multi-system diseases call for well designed and implemented community programs to improve outcomes for clients and families living within Saskatchewan communities. The innovative disruptions utilized by Home First to achieve success have not been clearly identified. This study will contribute to new knowledge to support the Saskatoon Health Region to establish and maintain interprofessional healthcare teams and care delivery models relevant to the care of older adults living with complex care needs in the community. By delineating the processes of interdisciplinary teams, describing the relationships, including patient engagement, among and between team members, and explaining the function of team leadership, a next step from this research is a pilot study. A pilot study would provide an opportunity to bridge the gap between rural and urban service initiatives and support capacity building within rural communities to support older adults to age-in-place.
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Research Showcase 2015
Principal Investigator
Ms. Julie DeGroot
Research & Health Information Services
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Donna Goodridge
Susan Sommerfeldt
Vera Caine
donna jouan-tapp
Brenda Rossow-Kimball
Charlotte Berendonk
2015-2016 Research Connections Grants
One year
FUNDING RECEIVED
$5,000SHRF
Description
Research Showcase is an annual research sharing and networking event, hosted by the Research Department of the Regina Qu'Appelle Health Region (RQHR). Every year, this event draws together a diverse gathering of participants including health and science researchers, policy makers, clinicians, physicians, students, and the general public in order to highlight research conducted within the region over the past year.
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First steps towards developing a porcine model for gonorrhea - optimization of infection of pig genital tract epithelial cells with Neisseria gonorrhoeae
Principal Investigator
Dr. Sidharath Dev
VIDO
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Donna Goodridge
Susan Sommerfeldt
Vera Caine
donna jouan-tapp
Brenda Rossow-Kimball
Charlotte Berendonk
Supervisor(s)
Dr. Heather Wilson (Lead Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Gonorrhea, caused by Neisseria gonorrhoeae, is the second most commonly reported bacterial sexually transmitted infection (STI) in Canada, and internationally. Saskatchewan has one of the highest provincial rates of gonorrhea in Canada. Rates of reported cases in Canada increased 53.4% between 2001 and 2010, with rates in 15 to 19 year old women being four times the national average. As many as 80% of infected women may be asymptomatic, and if untreated, they can suffer from pelvic inflammatory disease, infertility, and ectopic pregnancy. Gonorrhea can only be cured with antibiotics, and because certain strains have become resistant to all classes of antibiotics, it may soon be untreatable. No effective vaccines against gonorrhea currently exist. An important step in developing an effective vaccine is the establishment of an animal model that mimics infection and/or disease progression and transmission. Pigs are closely related to humans in terms of anatomy, genetics, physiology, and pigs and humans share highly conserved immunological parameters, therefore, this study intends to develop a pig model for Neisseria gonorrhoeae infection. The first step will be to develop and optimize gonococcal infection of porcine genital tract epithelial cells as a model. The researchers will examine the impact that hormones have on Neisseria gonorrhoeae infections, and how this infection impacts the host cell inflammatory and innate immune responses.
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Exercise and nutrition as treatment alternatives in women with Inflammatory Bowel Disease during preconception: Saskatchewan Multidisciplinary Inflammatory Bowel Disease Clinic [MDIBDC]
Principal Investigator
Dr. Whitney Duff
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Donna Goodridge
Susan Sommerfeldt
Vera Caine
donna jouan-tapp
Brenda Rossow-Kimball
Charlotte Berendonk
Supervisor(s)
Dr. Sharyle Fowler (Lead Supervisor) Dr. Jane Alcorn (Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$50,000SHRF
$50,000Crohn's and Colitis Canada
$100,000Total
Description
Dr. Whitney Duff is the Crohn's and Colitis Postdoctoral Research Fellow exploring alternative treatments in an effort to manage symptoms and treat inflammation in women in the preconception phase who suffer from an inflammatory bowel disease. Poorly controlled symptoms of inflammatory bowel diseases in women in their child-bearing years have a negative impact on both fertility and quality of life. Although many medical therapies are safe to use in pregnancy, pharmaceutical use during pregnancy can be a source of fear and anxiety for many patients. Thus, alternative approaches are needed. Potential participants will be recruited from the recently established Preconception and Pregnancy Inflammatory Bowel Disease Clinic within the University of Saskatchewan. Assessment of quality of life and objective markers of disease activity and fertility status will be completed at baseline and at regular intervals throughout the intervention. The intervention will be moderate intensity exercise supplemented with novel nutritional strategies theorized to manage symptoms and treat inflammation in inflammatory bowel disease patients.
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From Elders to Youth: A Traditional Indigenous Knowledge Gathering
Principal Investigator
Dr. Jo-Ann Episkenew
Indigenous Peoples' Health Research Centre
Indigenous Peoples' Health Research Centre
University of Regina
Co-Principal Investigator(s)
Dr. Joel Lanovaz
Co-Investigator(s)
Donna Goodridge
Susan Sommerfeldt
Vera Caine
donna jouan-tapp
Brenda Rossow-Kimball
Charlotte Berendonk
2015-2016 Research Connections Grants
Two year
FUNDING RECEIVED
$5,000SHRF
Description
The Indigenous Peoples' Health Research Centre will host a national gathering of Traditional Indigenous Knowledge holders, scholars, and students (graduate, undergraduate, and high school) at the University of Regina February 19-21, 2016. This invited gathering will bring together traditional Indigenous knowledge holders, researchers, and students from across Canada for the purpose of inter-generational transmission of Traditional Indigenous Knowledge (TIK) to advance health and well-being in contemporary contexts. Other conference venues will be the First Nations University of Canada and the All Nations Healing Hospital and Treaty Four Governance Centre in Fort Qu'Appelle.
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Novel Methods for Computational Risk Assessment of Thyroid Nodules in Sonographic images
Principal Investigator
Dr. Mark Eramian
Computer Science
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Gary Groot
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Thyroid nodules are very common, and, although some are cancerous, most are benign. Assessment of thyroid nodules is difficult; the first step is an ultrasound to assess the thyroid gland and adjacent lymph nodes. Human judgments are used to determine the need for follow-up procedures including biopsy and/or surgery. The number of referrals for biopsies and surgeries of minimal risk thyroid nodules that are ultimately determined to be benign is high, resulting in higher than necessary health-care costs, increased wait-times for genuinely necessary surgeries, and anxiety for patients with benign nodule who undergo biopsy or surgery. This project aims to enhance the accuracy of thyroid ultrasound diagnosis and reduce the number of unnecessary biopsies and surgeries of thyroid nodules in Saskatchewan. This project will develop a prototype proof-of-concept system that will provide risk assessment based on novel computational methods that perform deep learning for extracting nodule features in ultrasound images and integrate them with current best practice use of a dedicated thyroid imaging reporting and data system (TI-RADS). Currently no computational image analysis methods have been integrated with human assessment based risk scores. We hypothesize that such a hybrid approach will significantly reduce the number of biopsies and surgeries performed on low-risk nodules (>20%). We will compare assessments with TI-RADS alone, to assessments with both TI-RADS and computational methods and compare their efficacy to reduce unnecessary surgeries.Success of the proposed prototype in improving diagnosis will position our team to secure funding for longer-term wherein a fully-automated thyroid nodule assessment system is envisioned which will provide detailed risk assessment for thyroid nodules. Further, we would attempt to combine this system with a large public database of richly annotated images of thyroid nodules, and an image and metadata-based search system for this database would be designed to allow practitioners to examine historical cases similar to that of a given patient and facilitate case-based reasoning and learning.
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Adolescent Exercise for Bone Health
Principal Investigator
Dr. Marta Erlandson
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Alan Rosenberg
Louise Humbert
Adam Baxter-Jones
Philip Chilibeck
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Physical activity during the growing years has a beneficial impact on bone development, with the most active children laying down more bone compared to less active peers. Greater bone mass from childhood carries into young adulthood and, if maintained, may reduce the risk of bone fragility and related fracture later in life. The type of exercise required to bring about the greatest benefits for bone development remains unknown. Most physical activity programs have focused on lower limbs, paying little attention to upper limb exercises. The purpose of this study is to investigate the effect of a school-based physical activity intervention that challenges the upper and lower limbs on bone development for both short- and long-term health benefits. This study will provide a first step in identifying the type of physical activity interventions with the greatest long-term bone health benefits. It will provide new knowledge related to determinants of health status, one of our provincial health priorities.
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Aboriginal Women Athletes' Flourishing in Sport
Principal Investigator
Dr. Leah Ferguson
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Tara-Leigh McHugh
Sean Lessard
Louise Humbert
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$83,180SHRF
Description
Sport participation fosters a range of positive physical, mental, emotional, spiritual, and social health outcomes. Aboriginal peoples in Canada encounter many barriers to participate in sport and remain at a disadvantage to achieve these health gains. Aboriginal women athletes, in particular, experience many challenges and they continue to struggle to increase their recognition and participation in sport. The purpose of this research is to explore Aboriginal women athletes' meanings and experiences of flourishing in sport and to identify culturally-relevant strategies to allow them to reach their potential and attain health outcomes. It focuses on the voices of a core group of 15 Aboriginal women athletes competing at the provincial level in various sports. Their understandings of flourishing in sport and unique stories of journeying towards reaching their full potential will be told through talking circles, individual interviews, artifacts, and photographs. Generation of knowledge about the perspectives, experiences, needs, and lives of Aboriginal women athletes will help guide policy development and sport programming truly capable of enhancing Aboriginal women athletes' sport participation, flourishing in sport, and overall health.
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Targeting non-responsive Her2-positive breast cancer with novel anti-Her3 alpha-particle labelled antibody drug radioconjugates
Principal Investigator
Dr. Humphrey Fonge
Nuclear Medicine
Medical Imaging
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Clarence Geyer
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Almost all patients with positive epidermal growth factor receptor II (Her2) breast cancers are resistant (both de novo (innate) or acquired resistance) to the available treatment options. The most widely studied mechanism of resistance involves the co-expression of other growth factor receptors and their ligands notably epidermal grow factor receptor III (Her3). Drs. Fonge and Geyer will develop a new drug molecule that will specifically target Herceptin (current standard of care for this cancer type) insensitive breast cancer that co-expresses Her2 and Her3. This new molecule will consist of two very potent components namely a high energy α particle (225Ac) and a potent cytotoxic drug maytansinoid (DM1) linked to each other by high affinity human anti-Her3 antibody. This novel antibody drug radioconjugate (ADR; 225Ac-mAb-PEG-Mal-DM1) will be evaluated in Herceptin insensitive cell lines and in mice xenografts. The hypothesis is that treating breast cancer with a single molecule that contains a very potent drug and high energy radiation will lead to eradication of the cancer cells compared to the single agents (radiation (225Ac) or drug alone (DM1)). The ADR will be assessed following three aims: the development of the ADR; evaluation for its affinity and ability to kill resistant human breast cancer cells; and the effectiveness in mice bearing resistant human breast cancer tumors. Drs. Fonge and Geyer will develop an imaging agent for this ADR that will allow us to use SPECT/CT imaging to monitor the fate and response to treatment of the ADR in mice in real time.
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Nesfatin-1 Regulation of Energy Balance
Principal Investigator
Dr. Kavishankar Gawli
Veterinary Biomedical Sciences
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Clarence Geyer
Supervisor(s)
Dr. Suraj Unniappan (Lead Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Obesity and diabetes are debilitating diseases reaching pandemic proportions. Recent statistics indicated that roughly 25% of Canadians are obese, one billion of the global population is obese, and about 5% of Canadians have diabetes. Several hormones are involved in regulating blood glucose levels and body weight. Defects in the production, secretion and/or action of these hormones could contribute to certain types of obesity and/or diabetes. There is a great deal of interest in using naturally occurring hormones for the treatment of diabetes and obesity. Nesfatin-1 is a recently discovered natural hormone found in humans and other animals. This research will determine what will happen to food intake, body weight and blood glucose if nesfatin-1 is not produced in the body. This will be achieved using a mouse model with a dysfunctional gene encoding nesfatin-1. The experiments will be conducted in normal, diabetic and obese mice lacking nesfatin-1. This research will help in understanding how critical nesfatin-1 is in normal, diabetic and obese mice.
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Cellular immunotherapy for atopic dermatitis and the 'atopic march' to asthma
Principal Investigator
Dr. John Gordon
Division of Respirology, Critical Care and Sleep Medicine
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Elemir Simko
Duane Lichtenwald
Christopher Rudulier
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$20,000SHRF
$20,000The Lung Association of Saskatchewan
$40,000Total
Description
Atopic dermatitis (AD), or eczema, is a chronic skin condition that affects ~30% of children and ~2% of adults in industrialized countries. Of relevance to Saskatchewan, its pathology is exacerbated by dry climates. AD costs Canadians $1.2B annually, dramatically decreases the quality of life, and brings high socioeconomic costs, but it is also strongly linked to asthma; many AD patients progress naturally to subsequently develop asthma in a phenomenon known as “the atopic march”. Indeed, ≈70% of children with severe AD develop asthma, while only ≈8% of children without AD do so. It is proposed that the broken and inflamed skin of AD lesions (i.e., versus intact skin) allows allergens, which are otherwise harmless proteins found in the environment, to enter the body, triggering an allergic immune response that is initially confined to the skin. However, with time, allergic cells populate the entire body, such that subsequent inhalation of the allergen triggers allergic inflammation in the airways (i.e. asthma). Like asthma, AD is driven by an inappropriate immune response. We propose to use suppressive immune cells, called suppressive macrophages (sMacs), to silence the AD immune response in the skin. Decreasing the AD response will allow the skin to heal, re-establishing its ability to keep out allergens, but it will also spread to suppress the responses against the allergens throughout the body and thereby prevent sensitization for asthma. We will test our hypothesis in a mouse model of AD, and in vitro with human cells generated from the blood of AD donors. Our approach has the potential to increase the quality of life of people with AD and to derail the atopic march, with its ultimate legacy of asthma, further adding to the savings in societal and healthcare costs. The preventative nature of the asthma component of our strategy sets it apart from the majority of asthma strategies, which are directed at treating established disease (i.e. therapeutic approaches); these latter efforts are substantially complicated by the fact that there are many different types of asthma. Preventing the development of asthma should be substantially less complex than reversing established disease.
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RESOLVE Saskatchewan's RESOLVE Research Day 2015
Principal Investigator
Dr. Mary Hampton
Luther College
Psychology
Luther College, University of Regina
RESOLVE Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Elemir Simko
Duane Lichtenwald
Christopher Rudulier
2015-2016 Research Connections Grants
One year
FUNDING RECEIVED
$5,000SHRF
Description
RESOLVE Research Day is held once per year across three prairie provinces and it is RESOLVE Saskatchewan's turn to host. The conference showcases researchers, policy makers, service providers and those who have personally experienced intimate partner violence. This year our theme is Intimate Partner Violence - Engaging Beyond the Survivor. In addition to the plenary sessions with keynote speakers, we expect to have 16 research and information sessions.
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Understanding Lymphedema Symposium
Principal Investigator
Dr. Liz Harrison
Physical Therapy
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Catherine Jeffery
2015-2016 Research Connections Grants
One year
FUNDING RECEIVED
$5,000SHRF
Description
This symposium will provide an evidence-based update on the management of lymphedema with a focus in the treatment areas of lower extremity, obesity, and breast cancer. Symposium topics will promote interprofessional treatments of lymphedema in Saskatchewan that is consistent with and based on best-practice guidelines. The format will include plenary sessions and interactive small group workshops.The target audience for the symposium is: Physical Therapists, Occupational Therapists, Nurses, Nurse Practitioners, Pharmacists, Physicians, Massage Therapists, Kinesiologists, Chiropractors, Psychologists, Podiatrists, Social Workers, students in these disciplines, other interested health professionals, policy makers, and program planners. Symposium participants will be able to:• Describe and implement the best practice guidelines for treatment of all types of lymphedema, regardless of cause.• Facilitate evidence-based compression management strategies across Saskatchewan. • Outline provincially consistent treatment-planning principles for lymphedema management for the purpose of mitigating the consequences of lymphedema.• Facilitate lymphedema management program planning to ensure maximum benefits for patients.The symposium will be held at University of Saskatchewan's Academic Health Science Building, May 6-7/16. Registration is available online: www.usask.ca/cpte.
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Seasonal and daily variation in physical activity and sedentary behaviour: Associations with cardiometabolic health
Principal Investigator
Dr. Katya Herman
Kinesiology & Health Studies
University of Regina
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
Catherine Jeffery
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Evidence exists for seasonal or weekday-weekend variations in physical activity (PA) in some geographies. However, there is little evidence that these inconsistent patterns, contrasted with more consistent PA, negatively impact health outcomes -- beyond total or average PA levels (e.g. if PA guidelines are met, regardless of patterns to get there). This research will investigate how seasonal and within-week variations in PA and sedentary behaviour (SED) affect cardio-metabolic health outcomes in adults. The objectives are to 1) describe seasonal (winter, spring, summer, fall) variations in PA and SED; 2) describe daily variations in PA and SED (e.g. active daily vs. "œweekend warrior"); and 3) investigate how different patterns are associated with weight status, percent body fat, blood pressure, and blood cholesterol and glucose levels. Participants aged 20 to 65 will visit the University of Regina four times in one year to have measures taken, and complete a questionnaire. Then participants will wear a small computerized device on a belt at their hip for seven days to measure their PA and SED levels. The summer-winter climate extremes in Saskatchewan may be more likely to produce inconsistent PA patterns compared to more moderate climates. The results of this research may provide insight into the higher rates of obesity in Saskatchewan, allowing for better targeted interventions to increase PA, reduce SED, and ultimately reduce obesity and its health consequences.
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Redefining the role of Gardnerella vaginalis in the vaginal microbiome
Principal Investigator
Dr. Janet Hill
Veterinary Microbiology
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
David Palmer
Deborah Money
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,430SHRF
Description
A common and important condition for women occurs when the fine balance of healthy bacteria in the vagina becomes disrupted resulting in a condition often called ‘bacterial vaginosis' (BV). This disruption in the vaginal bacterial ecosystem results in symptoms of vaginitis with excessive discharge and odour, but this can have even more serious consequences including placing women at higher risk of getting sexually transmitted infections (STI) including HIV, as well as placing pregnant women at higher risk of preterm birth. Saskatchewan has disturbingly high rates of sexually transmitted infections and HIV in women, especially among Aboriginal women. In particular, Aboriginal women experience higher rates of preterm birth than non-Aboriginal women. The cause of this is complex, but BV is thought to be a contributing factor. Diagnostic tests for detection of BV and strategies for treatment remain ineffective. A particular bacterium called Gardnerella vaginalis is considered a hallmark of BV, but its classification as a disease-causing bacterium is complicated because it is also commonly found in healthy women. Our research group has already discovered that G. vaginalis consists of subgroups distinguished by the genetic make up of the bacteria and by their distinct behaviours. We have identified G. vaginalis genes that may relate to different ability to cause disease (virulence factors) among subgroups. Understanding these characteristics will permit a more sophisticated understanding of vaginal community composition associated with health and disease and enable the development of effective diagnostic tests. We will build on an established research team with expertise in microbiology and women's health, adding expertise in protein characterization. Our interdisciplinary approach will allow us to identify and characterize virulence factors distinguishing G. vaginalis subgroups and catalyze further development of women's health research capacity in Saskatchewan. The results will position us for further research focused on elucidating the role of G. vaginalis in initiating and maintaining abnormal vaginal microbiota, and developing improved diagnostic tools for evaluating vaginal health.
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Partnering Together to Improve Palliative Care in Long Term Care Homes
Principal Investigator
Dr. Paulette Hunter
St. Thomas More College
Co-Principal Investigator(s)
Dr. Paul Babyn
Co-Investigator(s)
David Palmer
Deborah Money
2015-2016 Partnerships for Health System Improvement (PHSI)
Three year
FUNDING RECEIVED
$80,000SHRF
$400,000CIHR
$480,000Total
Description
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Examining the Developmental Origins of Kidney Disease in Infants of Diabetic Mothers using Urine Proteomics
Principal Investigator
Dr. George Katselis
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Roland Dyck
Co-Investigator(s)
Robin Erickson
Joshua Lawson
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Kidney failure is a devastating disorder for affected individuals and their families, and treatment using dialysis and transplantation requires a disproportionate share of health care resources. Diabetes is the most common cause of kidney failure in Canada and First Nations people experience marked ethnic-based disparities in the incidence of both type 2 diabetes and diabetes-related kidney failure. A key factor in the epidemic of diabetes among First Nations people is the role of diabetic pregnancies. Gestational diabetes and pre-gestational type 2 diabetes are both more prevalent among First Nations women and enhance the risk of type 2 diabetes, and possibly diabetic kidney disease, in their offspring. This research aims to identify infants of diabetic mothers who are at increased risk for kidney disease. This would provide an opportunity for prevention of kidney failure through surveillance of affected children and initiation of kidney-protective therapy. We will use mass spectrometry-based clinical proteomics to characterize and compare the urine protein profiles of infants of diabetic and non-diabetic mothers. We will examine if differences in protein markers exist between the two groups at birth, and if these differences suggest abnormal kidney development related to in-utero exposure to diabetes. We anticipate that the application of mass spectrometry will provide the platform from which to develop a standardized diagnostic procedure to monitor infants for early development of kidney disease.
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Optimizing in vivo assessments of cortical bone porosity and strength: A validation study linking advanced imaging, mechanical testing and finite element modeling
Principal Investigator
Dr. Chantal Kawalilak
Mechanical Engineering
Engineering
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Roland Dyck
Co-Investigator(s)
Robin Erickson
Joshua Lawson
Supervisor(s)
Dr. James (J.D.) Johnston (Lead Supervisor) Dr. David Cooper (Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Osteoporosis is called brittle bone disease, because it makes bones fragile and more likely to fracture, especially when a person falls. Approximately two million Canadians live with osteoporosis, costing our health care system $20 billion each year. Wrist fractures are the most common type of osteoporotic fractures. Current osteoporosis diagnostic tools are unable to identify individuals with high fracture risk. The overall goal of this research is to develop and validate a new method for determining bone strength that can be used to identify individuals at risk of wrist fracture. Synchrotron-based imaging will be used to optimize measurements of bone micro-architecture provided by advanced clinical imaging, and the development of a computer model will estimate wrist bone strength when falling onto the outstretched hand. This research is scientifically important and clinically relevant as findings will improve our understanding of how to characterize bone micro-architecture underpinning osteoporosis, bone strength and fracture risk.
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Validation of the Alive activity monitor in cardiac rehabilitation patients
Principal Investigator
Dr. Andrea Lavoie
Cardiology
Cardiology
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Roland Dyck
Co-Investigator(s)
Sebastian Harenberg
Payam Dehghani
John Patrick Neary
Jenny Basran
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$38,820SHRF
Description
The longitudinal measurement of vital sign has been an integral aspect of gaining information about patients' cardiovascular health after a cardiac event. Traditionally, vital sign monitoring involves stationary and/or minimally portable devices. However, recent developments in wearable technology have made it possible that consumer-based products are now equipped with functions that provide reliable and valid longitudinal information about one's health. Some activity monitors include, among other functions, measurements of heart rate, electrocardiogram (ECG) and step count. The devices provide activity updates to the user by transferring the gained data to an online platform that is accessible via computers and other internet-ready devices (e.g., smart phones). Activity monitors bear great potential for cardiac rehabilitation. The devices provide accurate information about the amount and intensity of rehabilitation exercise. In addition, the devices aid to ensure that the patient is exercising safely. Through routine monitoring of cardiovascular function, the risk of a heart event could be detected before they occur. Over 1400 patients receive percutaneous coronary intervention or open-heart surgery each year in the Regina Qu'Appelle Health Region (RQHR). Only approximately 27% engage in cardiac rehabilitation after surgery despite the proven benefits (e.g., less hospital readmission, morbidity, mortality). In addition, health regions in Southern Saskatchewan currently offer a structured cardiac rehabilitation program only in major centres. Yet, many patients in Saskatchewan would benefit from accessible and low-cost cardiac rehabilitation programs, particularly those that live in rural and/or remote areas. The use of activity monitors may aid in providing an inexpensive, safe and easy-to-use way of delivering cardiac rehabilitation in rural Southern Saskatchewan. However, before activity monitors can be used for these purposes, the validity of the devices needs to be demonstrated. Consequently, the objective of this study is the validation of the Alive activity monitor in a cardiac rehabilitation population.
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Health care utilization patterns among children with asthma
Principal Investigator
Dr. Joshua Lawson
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Roland Dyck
Co-Investigator(s)
Donna Goodridge
David Blackburn
Donna Rennie
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$19,988SHRF
$19,987The Lung Association of Saskatchewan
$39,975Total
Description
Asthma is one of the most common childhood conditions, costing Canadians hundreds of millions of dollars annually. Proper management of asthma can reduce health care costs and improve patient outcomes. For example, we know that regular use of controller medication and proper management leading to controlled asthma can significantly reduce hospitalization for asthma and health care costs, yet a large proportion of the population remain uncontrolled. We plan to identify patterns of management and gaps in care that are related to socio-demographic factors and the subsequent impact of these management patterns on health outcomes among children with asthma through the use of the Saskatchewan Health databases. Through the completion of our study, we will be able to better identify at risk groups. We will accomplish this by conducting a retrospective birth cohort study involving children born between 1995 and 2014. Through the linkage of these databases, we will be able to investigate the patterns of management in relation to outcomes of health care utilization (e.g. hospitalization and physician visits) as well as the relation with socio-demographic factors (e.g. age, sex, location of dwelling). More specifically, we will use linked administrative health databases in Saskatchewan to 1) Describe the predictors of poor asthma outcomes (hospitalization, high number of physician visits, poor control) and, 2) Describe asthma drug utilization and identify robust predictors of optimal drug use and adherence. Once we identify the current practices, gaps and basic associations from the current study, we will be able to design more specific studies on key issues through the collection of additional exposure and clinical factors as well as the adherence information. This study is particularly relevant to Saskatchewan given the high prevalence of childhood asthma and the use of provincial databases, and will provide information as a resource for knowledge end users such as asthma educators, pharmacists, nurse practitioners and general practitioners, who care for the vast majority of children with asthma in Saskatchewan. We will work with the Saskatchewan Thoracic Society and Certified Asthma Educators as representatives of the aforementioned knowledge users as partners in this project.
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Development of Drugs which Bind to α-Synuclein for treatment of Parkinson's Disease.
Principal Investigator
Dr. Jeremy Lee
Biochemistry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Roland Dyck
Co-Investigator(s)
Edward Krol
Troy Harkness
Miroslaw Cygler
Christopher Phenix
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
The pathology of Parkinson's disease is not well understood but it is clearly linked to the misfolding and aggregation of the protein α-synuclein in neuronal cells. It is postulated that drugs which bind to α-synuclein and cause the protein to adopt a loop conformation will prevent aggregation of the protein and thus prevent the progression of the disease. We have recently demonstrated by nanopore analysis, NMR and isothermal titration calorimetry that drugs such as caffeine, nicotine and 1-aminoindan bind to α-synuclein and cause a loop conformation. Not only do these drugs prevent aggregation but there is good epidemiological evidence that they are neuroprotective and lower the incidence of Parkinson's disease. We propose to synthesize homo- or hetero-drug dimers which are expected to have increased affinity for α-synuclein and, therefore, should be suitable lead compounds for drug therapy of Parkinson's disease and could also be used for early diagnosis with PET scanning. Promising drug dimers will initially be evaluated in a yeast model which overexpresses α-synuclein. Further structural information will be obtained by X-ray crystallography of α-synuclein/drug complexes which will help to guide the development of second generation drugs.The incidence of the disease in Saskatchewan is about 0.3% of the population but rises rapidly with age to over 1% by age 65. There is also evidence that exposure to agricultural chemicals increases the risk of the disease. Thus, the disease is of particular economic importance to Saskatchewan with a large rural and aging population.Drug dimers designed from known neuroprotective agents are a novel approach to prevent protein misfolding. Positive initial results should lead to enhanced funding from the Weston Brain Institute, CIHR or the Parkinson's Society.
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Targeting epigenetic modification to eradicate cancer stem cells
Principal Investigator
Dr. Shuangshuang Li
Saskatchewan Cancer Agency
Cancer Cluster
Division of Oncology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Roland Dyck
Co-Investigator(s)
Edward Krol
Troy Harkness
Miroslaw Cygler
Christopher Phenix
Supervisor(s)
Dr. Franco Vizeacoumar (Lead Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
It is becoming more evident that successful therapeutic strategy must target cancer stem-like cells (CSCs), which control tumor initiation, progression, and maintenance. As the oncogenic evolution of tumor cells is partly controlled by DNA methylation, it has been proposed that DNA hypermethylation (caused by up regulation of DNMT1) might result in emergence of cancer stem and progenitor cells. These CSCs often give rise to secondary tumours and drug resistance. To efficiently eradicate CSCs, the researchers will induce the expression of DNMT1 in tumorsphere cultures that are known to be enriched for CSCs, and identify cancer drug targets. First, the researchers will establish an inducible cell line system to stably overexpress DNMT1 by Gateway and lentivirus-compatible plasmid, and then perform a shRNA-based screen in DNMT1 overexpressing tumorsphere cultures. From this screen, they will identify genes essential for the survival of CSCs by microarray-based analyses that is already optimized in the Vizeacoumar lab. Next the researchers will use a color assay, where the inducible cells will be evaluated for their ability to form tumorspheres by knocking down the hit gene identified in the screen. Confirmation of the hit in perturbing the formation of tumorspheres(over expressing DNMT1) will lead to the identification of cancer drug targets. More importantly, as CSCs are highly resistant to chemotherapy and radiotherapy, this approach will provide highly valuable therapeutic targets with high clinical relevance.
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Developing a low-intensity parent-directed CBT treatment program for children with anxiety via the On-Line Therapy Unit
Principal Investigator
Dr. Lynn Loutzenhiser
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Amy Zarzeczny
David Gerhard
Glenna Curry
Michelle McCarron
Senthil Damodharan
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,455SHRF
Description
Recent research suggests that 6.5% of Canadian children suffer from disabling anxiety; however, only 1 in 4 Canadian children actually receive treatment. Cognitive-behavioural therapy (CBT) has been shown to be an effective treatment for reducing anxiety in children, but it is expensive and resource intensive. Moreover, there are a number of barriers that make it difficult for parents to access these programs for their children, including economics, time, transportation and childcare. There is emerging evidence that supporting parents in providing CBT to their children with anxiety is an effective, low-cost alternative to traditional CBT. Consistent with the Saskatchewan Government's Mental Health and Addictions Action Plan for Saskatchewan, the overall goal of this research project is to improve access to mental health treatment for Saskatchewan children suffering from anxiety. To achieve this goal, our first step is to develop a parent-delivered internet-based CBT (ICBT) program for Saskatchewan children suffering from anxiety. We believe that developing a program for parents that can be accessed online will be able to address these barriers to treatment access identified above. Program development will be done through integrating information from a number of sources. Once we have identified the core content of the program, this information will be translated into an online format for delivery through the Online Therapy Unit. The evaluation phase of this program development will focus on evaluating a) the usability of the program and b) its sustainability in the Saskatchewan health context. The outcomes will form the basis of applications for larger, longer-term funding to support robust evaluation and broad-scale program implementation. Our team consists of researchers from multiple disciplines (i.e., Psychology, Computer Science, Health and Public Policy, Psychiatry) and knowledge users involved in the direct provision of services for children's mental health (i.e., Regina Child and Youth Services, Child Psychiatry, Saskatchewan Health). To our knowledge, this will be the first program to deliver parent-directed CBT to children using an online format.
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Youth Transitioning Out of Care: Resource and Knowledge Sharing Days
Principal Investigator
Dr. Marie Lovrod
Women's and Gender Studies/HUMFA
Women's and Gender Studies, English
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Amy Zarzeczny
David Gerhard
Glenna Curry
Michelle McCarron
Senthil Damodharan
2015-2016 Research Connections Grants
One year
FUNDING RECEIVED
$5,000SHRF
Description
The Youth Transitioning Out of Care: Resource and Knowledge Sharing Days is to introduce the new resource packages and training modules to young people, care providers, professionals and other community stakeholders working with the child welfare system. These knowledge sharing days is an opportunity for people to try out the handbooks, learn more about how they were developed, and understand how the resources can be used to support young people when planning their transitions out of care. The five one-day workshops will be held in Regina, Yorkton, Saskatoon, Prince Albert and Meadow Lake during the months of April and May.
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Concept Mapping to Improve Health through Urban Agriculture
Principal Investigator
Dr. Wanda Martin
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Rachel Engler-Stringer
Pammla Petrucka
Grant Wood
Eric Micheels
Debra Davidson
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,110SHRF
Description
Urban populations are growing worldwide, including a near doubling of the City of Saskatoon by 2023. Feeding this growing population will be an increasing challenge as we try to gain balance in the post-carbon era. Careful planning is essential to help meet the increasing demands for nutritious affordable food in growing urban settings. Urban built environments and design that embed access to food and physical activity directly influence population health. This research will inform changes to the built environment in Saskatoon catalyzing sustainable quality food and active living and contributing to improved health and resilience. These intents are reflected within two objectives: 1) To create an urban agriculture action plan for Saskatoon that can increase access to quality affordable food and; 2) To identify barriers and propose solutions to increased support for urban agriculture in Saskatchewan. More specifically, by revealing the depth of economic barriers, we will explore whether urban agriculture could also be a means to enhance income, particularly in lower-income areas of the city. We propose a case study design, involving participatory diagramming and concept mapping that includes a series of focus groups across the city and individual interviews with urban farmers. This research will contribute to the work of the Saskatoon Food Council and the City of Saskatoon, while tackling health inequities using an upstream approach. It will provide an action plan to inform and invite future projects to embrace multiple determinants of health including food, physical activity and income. This is an innovative project in both topic and methodology. Public health has not prioritized urban agriculture as an approach to improving health, and concept mapping is a novel method that necessitates real community involvement in rigorous data collection and analysis. Healthy built environments providing green space, food and potential for income are essential for better health through easy access to fresh foods, social cohesion and increased physical activity. This study will collectively explore, generate and prioritize innovations and ideas on a preferred future for municipalities' and food action groups' efforts to reduce food insecurity and improve health.
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The Impact of a Pulse-Based Diet Intervention on Measures of Infertility and Metabolic Syndrome in Women with Polycystic Ovary Syndrome: Changes in Liver Adiposity and Individual Responsiveness based on Genetic Variation.
Principal Investigator
Dr. Laura McBreairty
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Rachel Engler-Stringer
Pammla Petrucka
Grant Wood
Eric Micheels
Debra Davidson
Supervisor(s)
Dr. Gordon Zello (Lead Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 4 to 8 percent of women of reproductive age. Typically, Women with PCOS present irregular menstrual cycles, polycystic ovaries, and elevated levels of male hormones. Metabolic syndrome is a clinical diagnosis for an individual who exhibits risk factors, such as insulin resistance and abnormal blood lipid levels. Also, increased levels of liver fat are thought to be the liver manifestation of metabolic syndrome. Pulse-based diets (i.e. diets high in legumes) are effective for lowering insulin as demonstrated in a 16-week pulse-based diet and exercise intervention conducted by the researchers. The aim of this study is to determine the therapeutic effects of a pulse-based diet on levels of liver fat in women with PCOS, because elevated liver fat levels are one of the first detectable changes during the development of metabolic syndrome. This assessment will be added to an ongoing randomized control trial in which women with PCOS will be assigned to either a pulse-based diet or a healthy control diet for 16 weeks with both groups participating in an exercise program. Outcome measures will be determined following the intervention, and at six and 12 months.
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The Three Wishes Project: Individualized, Patient-Oriented, Compassionate Care for Palliative Patients and their Families
Principal Investigator
Dr. Michelle McCarron
Research and Performance Support
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Carmen Johnson
Patricia Engel
Deborah Cook
Sandra Lynn
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$37,222SHRF
Description
According to Statistics Canada, over 10,000 Saskatchewan residents aged 18 and older die each year, many of whom will have experienced a progression of illness over the course of days, weeks or months. In the 2014-2015 fiscal year, the Regina Qu'Appelle Health Region (RQHR) provided palliative care services to 420 in-patients and 317 home care patients. Palliative care recognizes death as a natural part of the life cycle and aims to provide comfort care to terminally ill patients when life-saving measures are no longer possible. Palliation is multi-faceted and holistic; it recognizes the importance of caring for all aspects of the person, including physical, mental, emotional and spiritual health, as well as supporting family members. This study will build upon recently published research from an intensive care unit in Ontario. Our pilot study will be innovative in its adaptation of the Three Wishes program to in-patient and home-based palliative care patients, with the aim of improving quality of life and psychosocial well-being for palliative care patients and their families in the RQHR. Participants will be asked to list three wishes that we will aim to fulfill via this project. Based on previous research, wishes are expected to be modest in nature and thus reasonable for the research team to facilitate (e.g., having their favourite flowers in the hospital room, dedicating a park bench in their memory, facilitating a Skype call to relatives overseas). A combination of quantitative data and one-on-one interviews will be used to examine the efficacy of this program in helping patients to foster a sense of closure and to improve their quality of life. This study will mark the first time that this program has been offered within a palliative care unit and home care program. This pilot study will be used as the foundation for an application to the Canadian Institutes of Health Research (CIHR) Project Scheme for funding to support a multi-site randomized controlled trial. This future trial will compare the efficacy of the Three Wishes program to other models of psychosocial support in a palliative care setting.
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Measurement Matters: The Art and Science of Developing the Right Indicators
Principal Investigator
Ms. Christine McDougall
Saskatchewan Epidemiology Association
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Joshua Marko
2015-2016 Research Connections Grants
One year
FUNDING RECEIVED
$3,400SHRF
Description
Symposium: 'Measurement Matters: The art and science of developing the right indicators'Measuring concepts that are meaningful to the health of a society is largely a scientific endeavor, but at times can seem like a creative pursuit. Still it has been said that “what matters is measured and what is measured ends up mattering”. Accurate, timely, and meaningful statistics can be a powerful agent for change. The Saskatchewan Epidemiology Association will bring together a full-day of thought-provoking presentations and discussions to contemplate this issue.Workshop: 'Identifying clusters in space and time: Tools to help prioritize resources for outbreak management'Clusters of disease events can arise in both infectious and chronic disease epidemiology. One of the first steps to investigating a potential cluster is determining whether the collection of cases is different from what we would expect based on chance alone. This one day workshop will introduce participants to a basic toolkit for identifying clusters of disease events based on their location and reporting time. The workshop will be a mix of some basic theory with hands on exercises. Participants will be encouraged to bring their own laptops as the software used in the workshop will be open access.
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Global Health: Nourishing Equity
Principal Investigator
Dr. Ryan Meili
Community Health & Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Joshua Marko
2015-2016 Research Connections Grants
One year
FUNDING RECEIVED
$5,000SHRF
Description
The College of Medicine, in collaboration with the College of Pharmacy and Nutrition, will host a Global Health Conference entitled "Global Health: Nourishing Equity" on October 17, 2015 at the Edward School of Business at the University of Saskatchewan. The goal of the conference is to address some of the very troubling and timely health equity issues that have relevance in Saskatchewan as well as in other parts of Canada and the world. There will be particular focus on equity issues surrounding food security and nutrition. We will bring in Dr. Ronald Labonte from the University of Ottawa who is the Canada Chair in Globalization and Health Equity and Dr. Valerie Tarasuk, a prominent researcher and advocate in the field of food security and health equity. The Conference anticipates 200-250 participants, mostly UofS researchers, students, academics, clinicians,as well as community members. There will be a poster session, a global health expo and a United Nations display on world hunger. A conference website will provide conference and registration information.
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One Health Research Symposium: what's in it for you?
Principal Investigator
Dr. Vikram Misra
Veterinary Microbiology
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Amanda Clarke
2015-2016 Research Connections Grants
One year
FUNDING RECEIVED
$2,500SHRF
Description
One Health is a signature research area at the University of Saskatchewan because of the increasing realization that the health of humans, animals, and the environment are inevitably linked in complex ways. The One Health Research Symposium: What's in it for you? is designed to promote a) knowledge exchange between participants of interdisciplinary projects b) capacity building for future collaborative research partnerships and c) future visioning of interdisciplinary One Health research at the University of Saskatchewan.
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Novel therapeutic interventions for managing cognitive comorbidities in status epilepticus
Principal Investigator
Dr. Farzad Moien-Afshari
Neurology
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Lisa Kalynchuk
Changiz Taghibiglou
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$119,977SHRF
Description
In Canada, 850 deaths occur per year in association with status epilepticus (SE), which is a state of prolonged seizures. In addition to high mortality, SE may cause significant brain damage, leading to profound memory impairments resulting in permanent disability. During SE, seizures become self-sustained and resistant to conventional anti-seizure drugs. This leads to neuronal death in vulnerable brain regions, especially the memory-forming region of the brain (i.e., hippocampus). It is known that the neuronal death in SE is caused by excessive activation of glutamate receptors (AMPA and NMDA) within the neurons (excitotoxicity). Current treatments for SE do not stop excitoxicity, which tends to progress in the days and weeks after the SE. This project will test the possibility that glutamate receptor antagonists might have neuroprotective effects. There are two antagonists that have been approved for use in humans, Amantadine (NMDA-antagonist) and Perampanel (AMPA-antagonist), but they have not been tested in SE. Using a rat model of SE, the researchers will assess the effects of Amantadine and Perampanel, alone or in combination, on SE-mediated changes in: 1- memory, 2- hippocampal cell death and changes in glutamate receptor expression, and 3- biochemical signature of neuronal damage using synchrotron imaging. If Amantadine and Perampanel prevent the deleterious effects of SE on neurons and memory, this could inform a subsequent clinical trial to assess the effect of these agents on patients with SE.
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Alzheimer's Disease and Dementia
Principal Investigator
Dr. Darrell Mousseau
Neuropsychiatric Research Unit
Psychiatry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Heather Hadjistavropoulos
Co-Investigator(s)
Lisa Kalynchuk
Changiz Taghibiglou
2015-2016 Saskatchewan Research Chairs
Five Year
FUNDING RECEIVED
$500,000SHRF
$500,000Alzheimer Society of Saskatchewan
$1,000,000Total
Description
There is accumulating evidence that clinical depression increases the risk for developing Alzheimer's disease. Recent published reports also suggest that certain widely prescribed antidepressants may be associated with an increased risk. Dr. Darrell Mousseau was awarded the Saskatchewan Research Chair in Alzheimer's Disease and Related Dementias to study the link between Alzheimer's disease and depression. Dr. Mousseau and his team of researchers have found that an enzyme, known for playing an important role in depression, can severely weaken brain cells and perhaps trigger the neurodegenerative processes that lead to Alzheimer's disease. The team is also looking at the possibility that it is not the depression itself that is a risk factor for Alzheimer's disease, but rather the treatment of depression that is an unintentional trigger. Through their program of research, Dr. Mousseau and his team hope to contribute to the development of a marker or molecular target that will allow for earlier and more accurate diagnoses, more effective treatments of Alzheimer-related dementia and/or a means of preventing the onset of the disease. They are currently examining several antibodies and peptides (small proteins) that could be useful in diagnosing the disease at earlier stages.
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Acute intermittent hypoxia to improve motor function after spinal cord injury
Principal Investigator
Dr. Gillian Muir
Veterinary Biomedical Sciences
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Lisa Kalynchuk
Changiz Taghibiglou
2015-2016 Spinal Cord Injury Research Grants
Two year
FUNDING RECEIVED
$75,000SHRF
Description
Regaining arm and hand function is of the highest priority for persons with cervical spinal cord injury. We propose to extend our SHRF-funded investigation of the potential of a novel non-invasive therapy, acute intermittent hypoxia (AIH) to improve forelimb function recovery in a rat model of cervical spinal cord injury, to incorporate exciting new insights. We previously showed that 7 days of daily AIH, administered 4 weeks after spinal cord injury, improves forelimb recovery on a ladder-walking task and significantly elevates plasticity-associated gene expression in spared spinal circuitry. But, despite an obvious trend toward recovery, this protocol was insufficient to significantly improve forelimb reach-to-grasp abilities in these rats, implying that the duration or timing of when to initiate treatment may not be optimal. In peripheral nerve injury paradigms, we have preliminary data supporting novel effects of AIH on nerve repair and polarization of immune cells toward a pro-repair phenotype. This suggests that AIH, beyond increasing plasticity in spared circuitry, may also favorably impact actual repair and immune cell responses following spinal cord injury. Thus, we propose to examine whether intervening earlier post spinal cord injury (1 week) and employing a longer AIH treatment protocol (ie. low level AIH 3 x per week after initial 7 day treatment) may favorably impact behavioral outcomes (i.e. forelimb reach-to-grasp abilities) by mitigating the secondary damage associated with spinal cord injury and/or enhancing regeneration of the injured circuitry. This will further elucidate the potential of this therapeutic intervention required for successful translation to clinical trials.
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Investigating the effect of haptic input on walking balance following a spinal cord injury
Principal Investigator
Dr. Alison Oates
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Catherine Arnold
Joel Lanovaz
Gary Linassi
Kristin Musselman
Renato Moraes
Stephan Milosavljevic
2015-2016 Spinal Cord Injury Research Grants
Two year
FUNDING RECEIVED
$73,621SHRF
Description
Falls and fall related injuries are more common in adults with an incomplete spinal cord injury (iSCI) compared to the general population. Lightly touching an object such as a railing improves walking balance in healthy individuals and in those who have a neurological condition such as a stroke. Haptic input (adding sensory information through touch) has not been tested as a method to decrease fall risk in persons with an iSCI. This research is the first to investigate the effects of adding haptic input on walking balance in someone with an iSCI and look at the differences in how haptic input is used. To provide haptic input, two tools will be tested: Gently touching a railing, and carrying devices called ‘anchors' that are similar to leashes with light weights at the bottom. Both individuals with an iSCI and healthy adults will have their dynamic balance safely measured in our state of the art lab as they walk in different ways with eyes open and closed. They will also be asked how they feel about the haptic tools and if they feel their balance has been improved. This research is designed to advance health care delivery for persons with an iSCI. Improving balance could increase the amount and quality of walking resulting in sustainable long term outcomes such as preventing falls, fall-related injuries and associated costs, reducing the complications of immobility, and improving the quality of life of those living with an iSCI.
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Tah-Nigahniwhak! (They will be leaders!) Growing up well in a northern Métis Saskatchewan community
Principal Investigator
Dr. Sarah Oosman
School of Physical Therapy
Physical Therapy
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Bonnie Jeffery
Tara-Leigh McHugh
Sylvia Abonyi
Thomas Roy
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$119,415SHRF
Description
In Canada, the Indigenous population is younger than the overall population, but experiences more chronic conditions at an earlier age. This trajectory is set early in life and is influenced by circumstances in which people are born, grow up, live, and age. Little is known about what Indigenous youth perceive is important to set them on a healthier life path, because research has focused on First Nations youth, resulting in a lack of knowledge specific to Métis youth. This research will reveal aspirations and current experiences for growing up well for Métis youth in a remote community. The project was developed in partnership with the Métis community of Île-à-la-Crosse, and is part of a broader program of research exploring living well across generations in northern Saskatchewan. This project is guided by an Aboriginal ecological epistemology and framework of health and well-being that community partners have identified as adaptable to Métis worldviews and knowledge. Data collection methods include sharing circles, conversations, interviews, and photo projects. Formal and informal supports currently available to youth in the community will be systematically identified and assessed for their alignment with the Métis framework and youth aspirations. The analysis will consider sex and gender in order to better understand growth and development needs. The findings will enhance our understanding of the intergenerational aspects of health and well-being among Métis populations and will inform program and policy interventions for Métis youth health and well-being.
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Research Matters: Facilitating Research Connections
Principal Investigator
Dr. Elan Paluck
Research and Performance Support
Research & Health Information Services
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Bonnie Jeffery
Tara-Leigh McHugh
Sylvia Abonyi
Thomas Roy
2015-2016 Research Connections Grants
Three year
FUNDING RECEIVED
$1,000SHRF
Description
The Regina Qu'Appelle Health Region (RQHR) is hosting an event to facilitate the development and growth of clinical research teams in Southern Saskatchewan. Attendees will include the RQHR Clinical Research Steering Committee and Clinical Research Advisory Group, select members from RQHR Senior Leadership and selected Deans and Vice-Presidents from the University of Regina. The objective of this event is to improve research collaborations between the RQHR and University of Regina. We anticipate this event will foster the creation of a short term strategy that builds on current research partnerships and clinical research teams and explores additional opportunities for collaboration.
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Development of an Oral Vaccine Platform for Neonates
Principal Investigator
Dr. Jonathan Pasternak
VIDO-InterVac
VIDO
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Bonnie Jeffery
Tara-Leigh McHugh
Sylvia Abonyi
Thomas Roy
2015-2016 Research Fellowship Top-up Incentive Award
Two year
FUNDING RECEIVED
$20,000SHRF
Description
Vaccines are the most effective tools for the control of infectious disease, however, their use in combating intestinal infection and diarrheal disease, which play a key role in childhood development and public health, has yet to be fully realized. The majority of pathogens enter the body through mucosal surfaces such as the intestinal mucosa, where classical vaccinations fail to trigger significant immunity. Oral vaccination not only has the benefit of inducing both mucosal and systemic immunity but avoids the need for both needles and health professionals for administration. A small number of whole-agent oral vaccines (live-attenuated virus) have been brought to market but a safe and effective oral subunit vaccine remains elusive. This is likely owing to minimal transport across the gut wall and a tendency for the body to respond to oral antigens with tolerance instead of immunity. The intestine of the neonate however, is unique. It is maintained for a short time in a “leaky” state to allow the passive transfer of maternal antibodies into the bloodstream. This project seeks to develop an oral subunit vaccination platform by capitalizing on this unique physiological state. Using swine as a large animal model, we intend to evaluate the transit and immunogenicity of the protein ovalbumin (an academic antigen) and relate this to the permeability of the neonatal gut over time. Dr. Pasternak's team will use Eshericia coli (E.coli) proteins as vaccine antigens, deliver them to neonates using dose/timing identified as optimal using ovalbumin, then establish the immune response and protection against diarrhea.
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Saskatchewan Stroke Symposium
Principal Investigator
Dr. Phyllis Paterson
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Helen Nichol
Michael Kelly
2015-2016 Research Connections Grants
Two year
FUNDING RECEIVED
$2,000SHRF
Description
The Saskatchewan Stroke Symposium is intended to bring together clinical and basic science stroke researchers from across Saskatchewan and key leaders in stroke research from Alberta. The symposium offers the opportunity for stroke researchers to learn from each other and develop new productive collaborations. The event is being planned by the CIHR-HSFC Synchrotron Medical Imaging Team and Saskatchewan Cerebrovascular Centre.
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Custody and Caring: 14th Biennial International Conference on the Nurse's Role in the Criminal Justice System
Principal Investigator
Ms. Cindy Peternelj-Taylor
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Helen Nichol
Michael Kelly
2015-2016 Research Connections Grants
Two year
FUNDING RECEIVED
$10,000SHRF
Description
The goal of the conference is to provide an interactive forum for nurses and other health care professionals to explore work-life and clinical issues that bridge the gap between the criminal justice system and the health care system. The conference provides opportunities to highlight innovations in practice, education, research, administration, and policy development in a variety of correctional, forensic mental health, and criminal justice environments, in Canada and internationally. Join us October 7-9, 2015 at the Delta Bessborough Hotel in Saskatoon, SK. For further information please see http://custodyandcaring.usask.ca/
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Sixth Annual CIHR-THRUST Retreat
Principal Investigator
Dr. Ingrid Pickering
Geological Sciences
Arts and Science
University Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Ashley James
Isaac Pratt
Kelly Summers
2015-2016 Research Connections Grants
Two year
FUNDING RECEIVED
$3,000SHRF
Description
CIHR-THRUST, the CIHR Training grant in Health Research Using Synchrotron Techniques, supports innovative health research training using the Canadian Light Source synchrotron. Based at the University of Saskatchewan, the training program engages clinical and biomedical health researchers with synchrotron specialists and other scientists and engineers to push the boundaries of synchrotron health research. Our Annual Retreat on December 9th in Saskatoon is the focus of our program year, bringing together the trainees with experts and invited guests -around 92 participants. This day comprises oral presentations, poster session for trainees, and a unique opportunity for synchrotron health research networking and brainstorming.
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Examining Innovations to Support Disadvantaged Patients with Complex and Integrated Community Health Care Needs
Principal Investigator
Dr. Vivian Ramsden
Family Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Ashley James
Isaac Pratt
Kelly Summers
2015-2016 SPOR Network in Primary & Integrated Health Care Innovations - Quick Strikes
One year
FUNDING RECEIVED
$10,000SHRF
$68,550Other Partners
$69,400CIHR
$147,950Total
Description
Literacy is now recognized as an important determinant of health and is closely linked to other social determinants of health in Canada. Persons with low health literacy, including urban Aboriginal persons with low levels of education, persons living in poverty and non-English or French speaking new Canadians, experience major obstacles in navigating the health care system in every province in Canada. In Saskatchewan, improving the capacity of the health care system to meet the complex needs of urban Aboriginal and underserved communities is of high importance. The Saskatchewan aspect of this project will focus on health literacy and helping individuals that would be considered vulnerable to become health advocates through engagement with one or more health care provider(s) and the co-creation of tools that will help them to ask questions of their health care providers.The involvement of people with low literacy in research is crucial because these people are: 1. more likely to live with multiple chronic conditions and at the same time may be excluded from mainstream healthcare services; and, 2. Under-represented in primary care innovation focused research. This project's aims are twofold: 1. Identify the complex health care needs and expectations of persons living with low levels of health literacy; and, 2. Co-create innovative solutions in two primary care jurisdictions with patients with low health literacy.
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Increasing utilization of home renal replacement therapies in First Nations communities: A collaborative and culturally relevant approach
Principal Investigator
Dr. Bonnie Richardson
Nephrology
Internal Medicine
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Michelle McCarron
Wilson Sutherland
Kyle Prettyshield
Siva Karunakaran
Joanne Kappel
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Renal replacement options or dialysis can be delivered in the home setting or hospital setting. Home dialysis offers a number of benefits over hospital-delivered dialysis. Peritoneal dialysis is the most common type of home dialysis. This dialysis is done through a catheter in an individual's abdomen which cleans the blood, typically overnight while the individual sleeps. The advantages of home dialysis include better quality of life, less travel and fewer dietary restrictions. Home- and hospital-based dialysis have comparable effectiveness. Home dialysis is significantly more cost effective than hospital dialysis. In Canada, the cost on a per year, per patient basis is almost double annually for hospital dialysis ($60,000) compared to home peritoneal dialysis ($32,000), marking a substantial savings when home peritoneal dialysis is implemented. These studies do not include costs to the individual, such as a family member taking time off work, driving or purchasing meals away from home when receiving hospital-based dialysis. Although, First Nations use dialysis more frequently than non-First Nations, they underutilize home dialysis at 16.2% vs 25.7 % in Saskatchewan. Hospital-based dialysis is only offered in Regina and Saskatoon, meaning that individuals who live in rural communities often incur substantial costs in time and money in order to receive services. The Federal Government, through Health Canada, pays $0.14 per km of travel for First Nations people. Hospital dialysis is usually done three times a week. Since First Nations live predominately in rural communities, the economic cost burden to both communities and governments are significant. The potential savings to First Nations individuals and governments are millions of dollars, annually.Our demonstration project with collaboration with the Federation of Saskatchewan Indian Nations (FSIN), two engaged First Nations communities, Health Canada and the Provincial Kidney Program (with three kidney physician specialists) will partner and offer culturally relevant kidney care, with the goal of increasing home dialysis. The intent is for the translation of knowledge and care to be empowered to First Nations communities.
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Registered Nurse and Physician Mentorship in Saskatchewan's Rural Communities
Principal Investigator
Dr. Noelle Rohatinsky
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Donna Rennie
June Anonson
Olufemi Olatunbosun
Sonia Udod
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$82,061SHRF
Description
Mentorships can serve to help organizations recruit and retain healthcare professionals. The purpose of this study is to modify an existing provincial mentorship program to meet the workplace transition and learning needs of registered nurses, nurse practitioners, and physicians in rural communities. The outcome of this research is a pilot rural-specific mentorship program that will be implemented and evaluated to assess the program's influence on supporting rural mentorships, easing workplace transition, strengthening community connections, and encouraging recruitment and retention of healthcare providers. The qualitative study, which involves semi-structured interviews, is important because rural communities struggle to recruit and retain healthcare providers. Innovative methods to achieve and sustain these beneficial relationships are integral to creating work environments that result in enhanced patient care and service delivery in rural communities. If healthcare providers feel supported in their work, they will be more likely to stay in their positions.
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Pediatric Autoimmune Neuropsychiatric Syndromes: A Saskatchewan-led International Transdisciplinary Conference for Development of Early Detection, Targeted Treatment, and Prevention Protocols
Principal Investigator
Dr. Alan Rosenberg
Pediatrics
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Donna Rennie
June Anonson
Olufemi Olatunbosun
Sonia Udod
2015-2016 Research Connections Grants
Three year
FUNDING RECEIVED
$8,800SHRF
Description
This event will gather together a multidisciplinary consortium of local and international experts to establish a collaborative network aimed at improving care, awareness and understanding of Pediatric Acute Onset Neuropsychiatric Syndromes.
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Investigating the therapeutic ability of tolerogenic dendritic cells in humanized asthmatic mice
Principal Investigator
Dr. Christopher Rudulier
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Valerie Verge
Co-Investigator(s)
Donna Rennie
June Anonson
Olufemi Olatunbosun
Sonia Udod
Supervisor(s)
Dr. John Gordon (Lead Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
The prevalence of allergic asthma is increasing worldwide. Allergic asthma is caused by unnecessary and damaging immune responses to harmless particles in the air, such as cat dander or pollens. Current therapies only target the symptoms of asthma, and do not address the underlying immunological cause of the disease. In fact, despite the widespread availability of drugs to control asthmatic symptoms, approximately 20 Canadian children and 500 Canadian adults die each year due to asthma. Thus, a therapy that corrects the pathological immune response that drives asthma is urgently required. This research will take the first steps in moving this therapy into humans by employing mice engrafted with allergic cells from asthmatic subjects. These cutting-edge "œhumanized" mice will enable the researchers to assess the effectiveness of our conditioned cells in turning off various well-characterized human asthma-causing allergic cells. This will provide the researchers with the critical information necessary to gain approval for future clinical trials involving the treatment of asthmatic subjects with these asthma-reversing conditioned cells.
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Social Determinants of Health Among Migrant Workers in Saskatchewan
Principal Investigator
Dr. Michael Schwandt
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Lori Hanson
Co-Investigator(s)
Sean Tucker
Andrew Stevens
Leslie Rea
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,691SHRF
Description
Throughout North America, migrant workers have been found to be particularly vulnerable to factors affecting health such as poor housing conditions, unsafe working conditions and reduced access to health services. This is a growing concern in Saskatchewan, where immigration is increasing dramatically. In spite of various legislation and regulations setting standards in these areas, migrant workers continue to be a vulnerable group of workers. To date there has been little research on factors associated with the health and safety of migrant workers in Saskatchewan.Our study will begin to address this gap in knowledge, informing the development of further research and policy pertaining to this population. Working with agencies that support newcomers to Canada, our novel research will study living and working conditions and access to health services among migrant workers in Saskatchewan, while examining some of the applications of major policies regulating these factors. This study represents the first research of its kind in Saskatchewan, offering an opportunity to provide information to decision-makers, and to support the enactment and refinement of policies and programs that benefit the health of migrant workers in the province. Following this study, we propose to utilize potential funding from the CIHR-SSHRC Healthy and Productive Work initiative and the Saskatchewan Workers Compensation Board to scale up our research, beginning with a comparative policy study and a robust quantitative study of migrant workers' health.
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Toward Equitable Distribution of Primary Health Care: A Comparative Geospatial Examination of Access to Community Based Health Services across Canadian Prairie Provinces
Principal Investigator
Dr. Tayyab Shah
Physical Therapy
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Lori Hanson
Co-Investigator(s)
Sean Tucker
Andrew Stevens
Leslie Rea
Supervisor(s)
Dr. Stephan Milosavljevic (Lead Supervisor) Dr. Brenna Bath (Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
There are growing concerns in Canada that the primary health care system is not as responsive as it could be in certain geographic areas. Some communities do not have the same access to a range of primary health care professionals, such as family physicians, nurse practitioners, and physiotherapists. These differences in access to health services have negative consequences for best meeting the health needs of all Canadians. This research will investigate the availability and geographic accessibility to family doctors, nurse practitioners, and physiotherapists in all three Prairie Provinces. We will map service delivery at both health region and municipality levels. Results in Saskatchewan will be compared with Alberta and Manitoba to see whether there is variation across provinces based on different provincial health policies. The results of this study will identify primary health care patterns and any under-served (or poorly served) populations in the Prairie Provinces. It will assist health care managers and policy makers to understand the distribution of existing key primary health care personnel resources. By noting differences in geographic accessibility to health services, this study will suggest several courses of action to help strengthen primary health care in Saskatchewan and better meet the health needs of everyone, regardless of where they live.
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Mobile Hepatitis-C Care and Treatment in Big River First Nation
Principal Investigator
Dr. Stuart Skinner
Infectious Diseases
Medicine
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Mamata Pandey
Co-Investigator(s)
Derek Klein
Stryker Calvez
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Saskatchewan has one of the highest rates of Hepatitis-C infections as compared to the national average and the infection rates are proposed to be four times higher in Indigenous people. Health outcomes of Indigenous people are further jeopardized due to lack of access to standardized care. This has exacerbated the communicable disease risk in these communities leading to further transmission and high disease related morbidity and mortality. In this project a collaborative relationship will be developed with Big River First Nations community to address the healthcare needs of Hepatitis-C patients. The objective is to develop an integrated care model that can be delivered through a mobile on-reserve unit at Big River. A community participatory research method will be adopted to engage community members and patients to identify needs and barriers to healthcare access. Through continued and meaningful community involvement the research team will develop an integrated care model that is best suited to address the unique needs of the community. Thereafter, the outcomes of the treatment group receiving treatment through the mobile on-reserve unit will be compared with the outcomes of a comparison group receiving treatment through other programs (cohort study design); to evaluate the quality of care received and health outcomes of patients. Finally, a cost-benefit analysis will be carried out to evaluate the sustainability and the scalability of this care-model. If this model adequately addresses the needs of the Hepatitis-C patients then this can be an alternative to address other infections such as HIV. This innovative project represents a first step taken to design and test an evidence based care-model that is best suited to address the unique needs of Hepatitis-C patients residing in under-served community in remote Saskatchewan. By employing technology and community engagement, the project aims to bring standardized care to Hepatitis-C patients residing in remote First Nations communities in Saskatchewan. The results of this pilot study will be employed to improve the structure of the care-model and secure additional funding from the Primary Integrated Health Care Innovations network.
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Synthetic Lethal Approaches to Metastatic Breast Cancer Therapy
Principal Investigator
Dr. Shari Smith
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Mamata Pandey
Co-Investigator(s)
Derek Klein
Stryker Calvez
Supervisor(s)
Dr. Deborah Anderson (Lead Supervisor)
2015-2016 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Breast cancer is the most commonly diagnosed cancer in women, and each year approximately 1.7 million new cases are detected globally. Metastatic breast cancers are the most aggressive form of this disease, with an average survival rate of less than two years. Metastatic breast cancer cells acquire new properties that allow them to migrate and invade surrounding tissue. Under normal conditions, non-cancerous cells produce CREB3L1, which restricts the production of proteins involved in cell migration and invasion. The researchers recently discovered that CREB3L1 is not present in ~53% of high-grade metastatic breast tumors. Therefore, they will use this unique feature of metastatic breast cancer cells as a way to target them for drug therapy. The aim of this study is to identify a target that when blocked with a drug triggers death in only cells lacking CREB3L1, and thus, sparing normal breast cells. This will be tested in a mouse model of breast cancer to determine whether this decreases tumor formation, and prevents the spreading of cancer to other organs. Since ~53% of high-grade breast tumors lack the CREB3L1 protein, the innovative research highlighting a potential targeted drug therapy could have significant positive impact on the breast cancer community.
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The Concept and Role of Place for First Nations Youth Mental Health
Principal Investigator
Dr. Angela Snowshoe
Educational Psychology
Educational Psychology
Education
University of Regina
Co-Principal Investigator(s)
Dr. JoLee Sasakamoose
Co-Investigator(s)
Amanda Scandrett
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,990SHRF
Description
First Nations youth in Canada have a considerably higher risk to develop mental health problems when compared to the general population. In Saskatchewan, the delivery of culturally sensitive and equitable treatment to First Nations youth has been identified as a priority by the Ministry of Health. However, many early career counsellors are not provided with adequate training that is needed to deliver culturally sensitive therapy for First Nations youth. While there is a growing understanding about the importance of culture for First Nations youth well-being, there has been little consideration of how the physical design of a counselling setting can facilitate (or hinder) First Nations youth ability to heal. The purpose of this research project is to address the need-service gap in service development and health policy related to culturally sensitive therapy with First Nations youth. The research project aims to explore the role of place in the healing process for First Nations youth in counselling settings across Saskatchewan. The research team will identify best practice examples for organizations and mental health service providers working with First Nations youth in Canada. The research results will provide a foundation from which health policy development and research initiatives can be carried out that emphasize the importance of place for First Nations youth mental health.
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Effect of Early Access Cardiac Rehabilitation on Ventricular Remodeling and Exercise Adherence: A Pilot-Feasibility Study
Principal Investigator
Dr. Corey Tomczak
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. JoLee Sasakamoose
Co-Investigator(s)
Larry Brawley
Mark Haykowsky
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Research initiatives have led to a reduction in deaths from heart disease. Despite this, a heart attack, also known as a myocardial infarction, remains a major health problem, because a growing number of individuals are living with heart damage from their heart attack. The heart damage reduces heart pump function and physical activity ability, and increases the chance for further health problems. Cardiac rehabilitation is effective for improving heart function after myocardial infarction. However little is known about the best time to start cardiac rehabilitation in order to maximum benefit for the damaged heart. The major objective of this study is to compare the effects of cardiac rehabilitation access time on heart function at one year following myocardial infarction. Specifically, to compare heart pump function in participants randomized to early access cardiac rehabilitation (1-week following hospital discharge) with those randomized to standard access cardiac rehabilitation (5-weeks following hospital discharge). This objective will inform us about the heart health benefits of early cardiac rehabilitation following a heart attack. Establishing these benefits will improve clinical decision-making, influence future Canadian cardiac rehabilitation guidelines and practices, and lead to improved hospital utilization efficiency and patient care.
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Building Nurse Manager Leadership within the Lean Management System
Principal Investigator
Dr. Sonia Udod
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Mrs. Patti Simonar
Co-Investigator(s)
Donna Goodridge
Thomas Rotter
Judy Duchscher
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Nurse managers (NM) are essential for building and sustaining workplaces that are conducive to safe, quality patient care. However, high role demands, lack of proper support, and constricting resources lead to NM role stress, increased turnover, and poor succession. Additionally, the increased strain on the healthcare system with respect to the need to reduce costs while improving quality of care has pressured its leaders to implement system-wide quality improvement initiatives, such as the Lean management system. In Saskatchewan, these two contributing factors result in a unique challenge: redefined NM roles within the context of Lean. The purpose of this study is to identify leadership behaviours and managerial practices of NMs that facilitate or impede the “normalization” of Lean in acute rural and urban hospitals in Saskatchewan. This study will be done in the context of Normalization Process Theory, which explains how complex interventions, such as Lean, can become routinely embedded in practice. This qualitative study will build upon previous work related to Lean implementation and features semi-structured interviews and focus group discussions with NMs. The research environment includes two contrasting health regions: Saskatoon (urban) and Kelsey Trail (rural). This will be the first study to generate evidence supporting practice-based theory regarding Lean and effective NM leadership practices. The research is relevant and important because NMs are pivotal players in the implementation of transformative healthcare practices that reinforce behaviours to promote and sustain strategies to reduce waste, improve coordination, and increase patient safety. Creating positive work environments supporting current NMs in providing patient and family-centered care through appropriate leadership styles and practices can also foster succession planning.
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Developing affinity reagents for molecular imaging and therapy of ovarian cancer
Principal Investigator
Dr. Maruti Uppalapati
Pathology and Laboratory Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Mrs. Patti Simonar
Co-Investigator(s)
Donna Goodridge
Thomas Rotter
Judy Duchscher
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Ovarian cancer affects nearly 2700 Canadian women every year with very poor prognosis. Unfortunately, most patients are diagnosed at an advanced stage, and current therapies do not improve the survival of these patients. Therefore, there is a clear need for new avenues of treatment. CA125/MUC16 is a protein that is overexpressed in greater than 80% of epithelial ovarian cancers, making it a good biomarker for targeted therapy. However, the complex nature, multiple splicing, and heterogeneity of the protein isolated from various sources has led to lack of reliable affinity reagents that can be used for non-invasive imaging and therapy in human patients. Using combinatorial protein engineering techniques, the researchers plan to generate protein-based affinity reagents that bind to a defined region on CA125 that is conserved across multiple isoforms. For this purpose, the researchers will develop several combinatorial phage libraries based on human proteins, and use a novel screening method to screen for binders to this conserved region of CA125. The generated reagents will be validated for improved sensitivity and specificity of binding across several ovarian cancer cell lines in comparison with other affinity reagents that are routinely used for staging ovarian cancer. These new reagents will have applications in molecular imaging and immuno-therapy of epithelial ovarian cancer cells expressing CA125.
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Public Health Nutrition Research Network Symposium, Connecting for Food Security: From Global to Local Perspective
Principal Investigator
Dr. Hassanali Vatanparast
School of Public Health
Nutrition
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Mrs. Patti Simonar
Co-Investigator(s)
Susan Whiting
2015-2016 Research Connections Grants
Three year
FUNDING RECEIVED
$1,500SHRF
Description
The 3nd Annual Saskatchewan Public Health Nutrition Research Network Symposium: Connecting for Food Security: From Global to Local Perspective aims to promote communication with stakeholders; encourage collaborative and multidisciplinary research; identify the needs in public health nutrition as a field of practice; and initiate programs that build capacity for practitioners. The event will be held October 17th, 2015 at the University of Saskatchewan. It features respected speakers Dr. Valerie Tarasuk and Dr. Ron Labonte, as well as many Saskatchewan researchers and practitioners in the field. This is a unique opportunity to meet and discuss with 2 internationally known leaders in the field of food security and public health nutrition. For symposium program and registration information, please visit www.usask.ca/phnr
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Developing targeted therapeutic reagents for prostate cancer
Principal Investigator
Dr. Franco Vizeacoumar
Oncology
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Maruti Uppalapati
Co-Investigator(s)
Jiong Yan
Sunil Yadav
2015-2016 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Given the advances that have been made in understanding the biology of prostate cancer, a major obstacle that limits the development of new drugs is the lack of appropriate, well-validated targets. Particularly, castration-resistant prostate cancers (CRPC) are the most aggressive form with complete absence of a clinically relevant targeted therapy. We will employ a phenomenon called Synthetic Dosage Lethality (SDL) that takes advantage of lethal combinations between gene pairs to cause the death of the cancer cell alone, provided one of the them is a genetic alteration causing cancer. Applying this technology, we will identify potential targets that can be translated to clinical studies upon validation. In this study, we provide a systematic strategy to build the pipeline to specifically identify cell surface molecules that when inhibited with synthetic antibodies should cause selective killing of CRPC cells. The funding from SHRF will position us to demonstrate proof-of-concept through in vitro studies. The therapeutic relevance will be systematically evaluated in animal models with further funding from CIHR. The successful completion of our project will trigger new targeted therapies for CRPC patients and we hope that our work will eventually contribute to better ways to manage this problem in patients in Saskatchewan and elsewhere.
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SYNTHETIC DOSAGE LETHALITY OF POLO-LIKE KINASE 1 IN COLORECTAL CANCER
Principal Investigator
Dr. Franco Vizeacoumar
Oncology
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Maruti Uppalapati
Co-Investigator(s)
Jiong Yan
Sunil Yadav
2015-2016 Establishment Grants
Three year
FUNDING RECEIVED
$119,901SHRF
Description
The commonly used therapies for cancer involve delivering high doses of radiation or toxic chemicals to the patient to help suppress tumor growth, but they also cause substantial damage to normal tissue. To overcome this we need targeted therapy that selectively kills cancer cells. This study will exploit genome instability, one of the most common unifying features of the cancer cells that primarily arise due to defective repair tools that maintain the integrity of the genome. There is another side to genetic instability that might work to the benefit of the patient, rather than to that of a tumor. Unlike normal cells, cancer cells do not have intact repair tools and succumb to any genotoxic insults. Rather than targeting a particular mutation that causes cancer, targeting these checkpoint tools can be employed without even having to know the underlying mutation. In order to do this in a systematic fashion, the researchers will employ a basic biological concept called "Synthetic Dosage Lethality" that takes advantage of interactions between gene pairs where an over-expression of a gene is lethal only when another, normally non-lethal, mutation or deletion is present. The researchers have developed a screening pipeline that can query every single gene in the genome and define these so-called synthetic dosage lethal interactions. This methodology will exploit those gene pairs that could be translated for cancer therapeutics.
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16th Biennial Violence & Aggression Symposium
Principal Investigator
Dr. J. Stephen Wormith
Psychology
Arts & Science
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Jiong Yan
Sunil Yadav
2015-2016 Research Connections Grants
Three year
FUNDING RECEIVED
$2,500SHRF
Description
The Violence & Aggression Symposium is a conference held biennially since 1986 that brings together academics, government and non-governmental representatives, aboriginal and other community groups/agencies to enhance knowledge, and build partnerships and collaborations aimed at understanding and addressing critical issues related to mental health and criminal justice. The 2016 edition will take place for the second time at the University of Saskatchewan, May 15-17, 2016, and will feature 4 plenary and 12 concurrent session presenters sharing their knowledge on an array of topics including mental health in the justice system, radicalization, adult and youth psychopathy and child exploitation.
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Metabolomic analysis of urine: Improving the diagnosis of asthma and COPD
Principal Investigator
Dr. Darryl Adamko
Pulmonary Medicine
Pediatrics
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Anas El-Aneed
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
There is no single test today that can accurately diagnose and help manage respiratory diseases in a typical family physician's office setting that is non-invasive. So family physicians try different therapies, often on a trial and error basis, hoping something will work. This is a serious problem that is leading to unnecessary hospitalizations and health costs. The overall purpose of Dr. Adamko's work is to provide a better method of diagnosing and managing respiratory diseases so that the correct treatment can be identified and started sooner, leading to improved wellbeing of the patient.This research proposes a unique approach to tackling this problem; the development of a simple urine test that would help doctors correctly identify specific airway diseases. Previous research has already shown that certain airway diseases produce cellular products (metabolites) in the urine and that the array, or “signature”, of metabolites differs between asthma and COPD. The objectives of this current funded project are to: 1) improve the research by further studying available human samples using a more sensitive technology called mass spectrometry; and 2) to establish patient groups in Saskatchewan.This research aims to dramatically improve diagnosis and the management of airway diseases and fits with the current health research priority areas of primary care settings. In addition, since Aboriginal people are over-represented among these patient populations, as are the elderly in the COPD population, this research also addresses the health needs of specific populations.
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Nature and nurture: A biopsychosocial exploration of the relationship between childhood trauma, adult attachment, and severity of depression and social anxiety in Saskatchewan.
Principal Investigator
Dr. G. Camelia Adams
Psychiatry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Scott Napper
Rudy Bowen
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$110,393SHRF
Description
There is an intricate interaction between nature and nurture. The earliest years in our physical, mental, and social development are critical. In these early years our trust in others and ourselves develops and when our early interactions are healthy, so are we. When they are not, neither are we. Adversity and unhealthy interactions in early life can shape our attachment to others and this template may stay with us throughout life. We are social beings and we spend our lives “attaching” to others.Successfully negotiating these attachments impacts how we function in our daily lives, including the impact on our health and wellbeing. Failure to negotiate these attachments can have adverse outcomes that can include depression, an acknowledged mental health burden and a leading cause of morbidity and mortality. In addition, social anxiety remains the most frequent anxiety disorder either alone or when comorbid with depression. Dr. Adams research aims to examine the psychological and biological vulnerability that arises from childhood trauma and how this trauma may impact attachment style(s) in adulthood. In addition, her team will examine the relationships between adult attachment styles, hormonal characteristics due to stress, and clinical severity in depression and social anxiety. Given the high prevalence and co-occurrence of these conditions, the research has the potential to provide immediate translational potential for diagnosis and treatment in a critical, yet understudied area.
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Mechanistic Analysis of miR-122 promotion of HCV replication
Principal Investigator
Dr. Yalena Amador Cañizares
Microbiology and Immunology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Scott Napper
Rudy Bowen
Supervisor(s)
Dr. Joyce Wilson (Lead Supervisor)
2014-2015 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Saskatchewan has a high incidence of HCV infection relative to the Canadian average, and a very high percentage of HCV infected people self-identify as First Nations. This makes HCV infection a priority health issue that affects both First Nations and non-First Nations Saskatchewan residents. Current HCV treatments are frequently ineffective and can induce virus resistance. Dr. Cañizares' team aims to discover how the host cellular micro-RNA, miR-122, promotes HCV infections and use the information to develop new ways to inhibit the virus and treat HCV infected patients. We hypothesize that miR-122 promotes HCV replication through specific activity of Argonaute 2 (Ago2), and by modifying protein binding to the HCV 5'UTR. The first objective of the research will be to focus on the host protein, Ago2, a key player in miR-122 promotion of HCV. miR-122 binds to Ago2 and then the complex binds directly to the RNA genome of the virus. What isn't understood is how the protein-RNA complex promotes HCV replication? Ago2 is a multifunctional protein with regions (motif) of the protein having different functions. By mutating each motif and then measuring the effect on HCV replication the key Ago2 functions required for miR-122 promotion of HCV replication will be identified. The research team also aims to identify novel host and viral proteins that bind to the HCV genome and investigate if miR-122 regulates (promotes or inhibits) their binding. This research will lead to a better understanding of the mechanism by which miR-122 promotes HCV infections and identify targets for therapeutic intervention.
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Effects of maternal immune activation during pregnancy on patterns of brain activity in the offspring: implications for schizophrenia
Principal Investigator
Dr. Lei An
Physiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Scott Napper
Rudy Bowen
Supervisor(s)
Dr. John Howland (Lead Supervisor)
2014-2015 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Schizophrenia is a severe, disabling brain disease that affects about 1 per cent of the population. Recently, cognitive impairments such as deficits in learning and memory have been emphasized as fundamental features of the disorder. However, the mechanisms through which developmental risk factors for the disorder lead to the cognitive impairments are not known. Dr. Lei plans to use a well-validated rat model of maternal infection during pregnancy, an established environmental risk factor for schizophrenia, to assess the specific changes in brain activity that may underlie cognitive symptoms of the disorder. Her team will test whether the offspring of pregnant rats exposed to a simulated viral infection during pregnancy display altered working memory, a specific type of memory altered in schizophrenia. In a second series of experiments, we will record the activity of single cells (neurons) in the brains of control and infection-exposed rats while they perform the working memory test. These results will enable us to describe the alterations in brain activity that occur during cognition on a single cell level for the first time. Dr. Lei's resarch may enable the development of novel therapeutics for schizophrenia that could improve the cognitive symptoms of the disorder.
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Strengthening Inter-Professional Ethics Education Practices of Nursing and Social Work Professionals in Saskatchewan: Deepening Understandings of Ethical Issues and Early Indicators
Principal Investigator
Dr. Ebin Arries
Nursing
University of Regina
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Randy Johner
Ann-Marie Urban
Joan Wagner
June Anonson
Florence Luhanga
Glenn Donnelly
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$36,512SHRF
Description
This research seeks to extend the theory and practice of ethics education of nurses and social workers by deepening our understanding of ethical issues and early indicators and develop an integrated framework. The aims of the research are to: design, implement and evaluate an inter-professional ethics curriculum; measure outcomes; and strengthen ethics education practices. The research objectives are to explore undergraduate students' and educational professionals' experiences of ethical issues in nursing and social work education and understand how they characterize early indicators; and understand ways in which they respond to and prioritize these ethical issues and early indicators and analyze for patterns of similarities and differences in their viewpoints. This study employs a Q-methodological research design.
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Development of theranostic agents for melanoma
Principal Investigator
Dr. Ildiko Badea
Pharmacy
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Humphrey Fonge
Kishor Wasan
Kamaljit Kaur
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Melanoma is a devastating skin disease due to its high propensity for metastasis. Internationally, the incidence of melanoma cases has increased by 45% since 1992, which emphasizes the urgent need for efficient therapy options. With the growing incidence of melanoma in Canada, the availability of new diagnostic tools (radioimaging and synchrotron-based biomedical imaging) and novel radiotherapeutics will lead to timely diagnosis and efficient treatment of melanoma patients of Saskatchewan. This research aims to develop new targeted theranostic (diagnosis and therapy) agents for melanoma, based on lipid nanoparticles incorporating an agent for imaging 111In and 225Ac for targeted radiotherapy. The objectives are to synthesize targeting peptide-conjugated lipids and formulate them into nanoparticles; to incorporate radioagents into the nanoparticles; to study their stability in a biological environment; and to evaluate targeting of the radiopharmaceuticals to melanoma cells. To achieve these objectives, the researchers will use the cyclotron to generate the radionuclides and synchrotron-based radiation to study the properties of the nanoparticles and their interactions with cancer cells. The long-term objectives are to develop a commercially viable product for the localization and treatment of metastatic melanoma.
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Glucocorticoid effects on acute neuroinflammation and chronic neurodegeneration
Principal Investigator
Dr. Lane Bekar
Neuroscience Research Group
Pharmacology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Humphrey Fonge
Kishor Wasan
Kamaljit Kaur
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Stress can have a profound effect on inflammation. Studies have shown that injecting the glucocorticoid corticosterone prior to an inflammatory challenge show an increased neuroinflammatory reaction, but if the injection occurs after an inflammatory challenge, the reaction is suppressed. Although previous studies have addressed the impact of acute and chronic stress on the magnitude of inflammatory responses, there has been little research that has addressed the duration of the response. In the context of inflammatory-mediated neurodegeneration where neuron death is dependent on the duration of inflammatory cascades, the duration of the response becomes extremely relevant. Could it be that acute stress primes both the inflammatory and anti-inflammatory pathways to allow an increase in magnitude of the inflammatory response with a shortened duration?Dr. Bekar's research aims to assess the effects of acute corticosterone on the magnitude and duration of systemic lipopolysaccharide-induced neuroinflammation and long-term neurodegenerative processes. The research will employ standard behavioral, histological and biochemical techniques in order to characterize different aspects of acute neuroinflammation as well as chronic neurodegeneration. A greater understanding of stress effects on the different aspects of inflammatory 'activation states' may lead to treatment regimens that can optimize immune responses for specific challenges. In any case, these studies are necessary to build a base of understanding for comparison with immune system changes under conditions of chronic stress that may be the basis for the rapid increase in chronic neurodegenerative conditions seen today in our society.
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All Ages, All Stages: Transitions in the Continuum of Hospice Palliative Care Conference and Clinical Day
Principal Investigator
Ms. Claire Belanger-Parker
Saskatchewan Hospice Palliative Care Association
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Humphrey Fonge
Kishor Wasan
Kamaljit Kaur
2014-2015 Research Connections Grants
Three year
FUNDING RECEIVED
$10,000SHRF
Description
The three sub-themes this year are Pediatric Palliative Care, Chronic Disease Management, and Palliative and Long Term Care. We will: Address the importance of Pediatric Palliative Care Advance the knowledge and skills of professionals in the field of Chronic Disease Management Advance the delivery of Palliative and Long Term Care Provide a networking opportunity for leaders, clinicians and members of the public Dates: May 13, Clinical Day, May 14-15, 2014, Conference Radisson Hotel, Saskatoon, SK 250 delegates including doctors, nurses, social workers, spiritual care people, volunteers To register: www.saskpalliativecare.org Click on Conference Registration Link
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Saskatchewan Cancer Research Conference
Principal Investigator
Dr. Keith Bonham
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Franco Vizeacoumar
2014-2015 Research Connections Grants
Three year
FUNDING RECEIVED
$3,000SHRF
Description
The Saskatchewan Cancer Research Conference will be held on June 18th, 2014 at the University of Saskatchewan, Health Sciences Building. The goal of the conference is to bring together Cancer Researchers from across the province to foster communication and collaborations, with a special emphasis on translational research. The Conference will feature an internationally respected keynote speaker (Dr. Phil Heiter from the University of British Columbia http://www.msl.ubc.ca/faculty/hieter) as well as Saskatchewan researchers. In addition, a poster session will provide trainees an opportunity to present their finding.
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Suicide: An Update on Assessment and Prevention
Principal Investigator
Dr. Rudy Bowen
Psychiatry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Stacey Lovo Grona
Co-Investigator(s)
Franco Vizeacoumar
2014-2015 Research Connections Grants
Three year
FUNDING RECEIVED
$1,650SHRF
Description
On Friday, March 20/2015, the Department of Psychiatry will host a conference entitled "Suicide: An Update on Assessment and Prevention". The venue will be the Saskatoon City Hospital Theatre. Speakers include Dr. Shawn Shea (New Hampshire), and Dr. Jitender Sareen, Manitoba. The purpose is to provide a novel look at suicide prevention for the benefit of allied health care professionals (psychiatrists, family physicians, psychologists, psychiatric nurses, social workers), researchers, trainees and community members in Saskatchewan. We expect approximately 100 registrants. For detailed information on agenda, speakers, learning objectives and registration, please refer to the attached event description.
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Determination of Matrix Metalloproteinase Expression in Symptomatic and Asymptomatic Human Carotid Artery Tissue
Principal Investigator
Dr. Josef Buttigieg
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. David Kopriva
Co-Investigator(s)
Tzu-Chiao Chao
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$21,650SHRF
Description
Atherosclerosis is the primary cause of heart disease and plays an important role in the development of stroke or stroke like symptoms. Often atherosclerosis is thought of as a blood flow problem: fat collects on the inside of arteries, eventually limiting the flow of blood or causing closing off the artery completely. While this may be the case in some people, more commonly a piece of the atherosclerotic plaque ruptures. When this happens, the free flowing debris can then lodge elsewhere (e.g. brain or heart) causing disruption of blood flow in that organ and causing death of cells (e.g. stroke or heart attack). While most people will develop atherosclerosis, only a certain subset of the population will develop unstable plaques that rupture and cause stroke. Individuals with stable plaques typically are not aware of their presence and only become aware when they are being examined for some other unrelated condition. What is not known are the factors that are involved in the transition from a stable plaque to an unstable plaque. To date, we can only determine that a plaque is unstable after it has ruptured and caused a stroke or heart attack. If we can determine whether an individual is at risk earlier, e.g. before a stroke or heart attack, we can then employ preventative measures (e.g. diet modification, surgery, or diet modification) much earlier and limit brain or heart damage. The goal of this study is to demonstrate our ability to analyze atherosclerotic plaques at the gene and protein level and thus be able to identify biomarkers. These biomarkers (either biopsy or blood sample) can then be utilized to predict plaque stability and thus allow preemptive treatment, before the plaque causes a stroke. The long-term goals are to take these initial findings and validate them in a larger population base (nationwide). Funding for the long-term goals will be sought from the Canadian Heart and Stroke Foundation and from CIHR.
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Role of pulmonary neuroendocrine cells in lung physiology
Principal Investigator
Dr. Josef Buttigieg
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. David Kopriva
Co-Investigator(s)
Tzu-Chiao Chao
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$119,926SHRF
Description
Diseases that affect the function of the lung such as asthma, chronic obstructive pulmonary disease, and pulmonary arterial hypertension are serious detriments to an individual's quality of life. Severe enough, these lung problems can often cause death. In Canada, lung diseases cost the healthcare system over $20 billion in 2010 an amount projected to grow to $24 billion by 2025. After heart disease and cerebrovasculor disease, lung disease is the third leading cause of death in Canada.In many lung diseases, the problem is essentially the inability to match blood perfusion - the process of a body delivering blood to a capillary bed - to ventilation. In a healthy lung, peripheral oxygen sensors such as the pulmonary neuroendocrine cells (pNEC) or clusters of pNEC called neuroepithelial bodies (NEB), play a key role in lung ventilation to blood perfusion. The innervated pNEC/NEB monitors changes in ventilation, and blood gasses relay this information to the brain and act to adjust pulmonary vasculature appropriately. However, little is known about the mechanism by which this occurs or how, in the diseased state, the function of these cells becomes altered. Using molecular immunocytochemistry (a laboratory technique used to anatomically localize the presence of a specific protein or antigen in cells by using a specific primary antibody that binds to it) and electrophysiological techniques (a branch of physiology that studies the relationship between electric phenomena and bodily processes), Dr. Buttigieg's team will investigate the mechanism by which pNEC/NEBs sense asphyxia and how this is impaired under developmental and environmental stimuli.
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Regina Qu'appelle Health Region and University of Regina research network meeting
Principal Investigator
Dr. Josef Buttigieg
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. David Kopriva
Co-Investigator(s)
Tzu-Chiao Chao
2014-2015 Research Connections Grants
Three year
FUNDING RECEIVED
$420SHRF
Description
On June 9th 2014, the University of Regina will be hosting a research networking meeting, hosting researchers from both the University of Regina (UofR) and the Regina Qu'appelle Health Region (RQHR). This is a direct invite event that seeks to foster a more collaborative health research environment between the two institutions. Access to this event is only through direct invitation via the Vice President Research (UofR) and Director of Research (RQHR)
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Tracking the Transmission of Bacterial Infections with Whole Genome Sequencing
Principal Investigator
Dr. Andrew Cameron
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. David Kopriva
Co-Investigator(s)
Jessica Minion
David Alexander
Ryan McDonald
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
The severe health burden of bacterial infections will continue to increase with the loss of effective antibiotics, growing and aging human populations, and eroding environmental quality. The best mechanism to prevent infection is to block transmission by identifying sources and transmission routes of infectious bacteria. DNA sequencing technologies are developing faster than computer technologies, making it possible to sequence all genes in multiple bacteria from an outbreak. This new level of genetic insight is revolutionizing epidemiology, the science of identifying routes of transmission and sources of infectious disease. This research will sequence 160 bacterial isolates from past outbreaks (2013-2014) and a future outbreak (2015) to identify sources of infection and routes of transmission. Bacterial pathogens from the Regina Qu'Appelle region will be used to interrogate the persistence of antibiotic-resistant bacteria in hospitals and care homes, while isolates from across Saskatchewan will reveal the dynamics of disease spread across the province at an unprecedented level of resolution. Specifically, the research will address the leading causes of antibiotic-resistant infections in hospitals and long-term care homes: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and genes for extended-spectrum β-lactamases. In addition, the researchers will use DNA sequencing to examine chronic infections caused by nontuberculous mycobacteria to determine if they are due to treatment failure or are caused by reinfection of susceptible patients. This study will evaluate a practical application of genome sequencing and enhance our understanding of disease transmission in Saskatchewan.
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RAGE mediates neurogenic airway hypersensitivity in asthma
Principal Investigator
Dr. Veronica Campanucci
Physiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. David Kopriva
Co-Investigator(s)
Juan Ianowski
Dean Chapman
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$20,000SHRF
$20,000The Lung Association of Saskatchewan
$40,000Total
Description
Asthma is an inflammatory disease of the airways causing that affects 6.5% of the population of Saskatchewan. Asthmatic patients suffer from pulmonary obstruction caused primarily by a decrease in the inner airway diameter as a result of excess mucus secretion and thickening of the walls of airways. “Asthma attacks,” characterized by severely obstructed breathing, is the main cause of asthma-related fatalities, which emphasizes the urgency for additional strategies to manage this disease. Asthma can be induced by inhaled allergens or by viral infections; which trigger innate and adaptive immune responses involving pattern-recognition receptors. One pattern-recognition receptor that has recently come to attention in chronic airways disease is the receptor for advanced glycation end products (RAGE). RAGE is a member of the immunoglobulin superfamily that recognizes pathogen- and host-derived ligands to initiate the immune response to tissue injury, infection and inflammation. Although the role of RAGE in lung physiology and pathophysiology is not well understood, recent studies have linked RAGE gene polymorphisms with airflow obstruction. This research will test the contribution of RAGE to neurogenic inflammation of the distal airways using the ovalbumin-sensitized model of asthma in wild type and RAGE knock-out mice.
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Analysis of membrane protein clustering in lymphocytes as a putative biomarker of therapeutic efficacy in mood disorders
Principal Investigator
Dr. Hector Caruncho
Division of Pharmacy
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. David Kopriva
Co-Investigator(s)
Juan Ianowski
Dean Chapman
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$118,890SHRF
Description
Major depression is a severe and devastating psychiatric illness that affects roughly 16 per cent of the population worldwide. Although numerous antidepressants have been developed, up to one third of patients don't respond to most currently used medications, and up to two thirds of patients never reach remission. Such a low response rate underscores the importance of developing new biomarkers of therapeutic efficacy in depression.Dr. Caruncho's research will aim to analyze membrane protein clustering in lymphocytes to see if they can be used as biomarkers of therapeutic efficacy in major depression and provide a basis for the development of personalized medical treatment. His team has previously published results suggesting the validity of this hypothesis.The team will perform experiments in a well-characterized animal model of depression to determine possible alterations in membrane protein clustering in lymphocytes during the depression cycle. They will also evaluate in antidepressant treatment any improvements to behavioral tasks designed to evaluate depressive-like behavior.A second set of experiments will be carried out using lymphocyte samples from depression patients to study alterations in membrane protein clustering in lymphocytes in treatment-resistant depression, and in major depression associated with different comorbidities. The team will study changes in membrane protein clustering in lymphocytes from depression patients after incubation in vitro with antidepressants.The outcome of this research aims to help better define a antidepressant treatment for each individual patients.
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Assessing the Healing Needs of Former Students of Indian Residential Schools and their Families
Principal Investigator
Dr. Brian Chartier
Psychology
St. Thomas More College
Co-Principal Investigator(s)
Dr. Tracey Carr
Co-Investigator(s)
James (Jim) Miller
Joanne Yakowec
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$28,668SHRF
Description
The Canadian Indian Residential School (IRS) system was created to aggressively assimilate Aboriginal children into white society. While a few positive aspects of the IRS experience have been acknowledged by former students, stories of sexual, emotional, physical and spiritual abuse and neglect are more far common. First Nations communities continue to be impacted by intergenerational effects of the residential school experience. Details regarding what sustains the healing process for this population remain relatively unknown. The research objectives are to understand the healing experiences of a sample of former students of residential schools and their families and to assess what resources are required to enhance healing efforts. The researchers will conduct the research in partnership with the Resolution Health Support Program (RHSP) in Saskatchewan. The program has been asked to collaborate on the research design and to play a key role in participant recruitment and data verification. This program, established in accordance with the IRS Settlement Agreement, provides emotional and cultural support to former students of residential schools and their families. A specific focus of the program is to support individuals as they undergo proceedings related to legal claims of IRS abuses. The objective is to interview up to a total of 25 RHSP workers, Elders, and family members at five program locations by employing a qualitative approach to understand the healing experiences among this population and to assess the necessary resources to enhance healing. Critical discursive psychology will be used to analyze the transcripts. The ultimate goal of this research is to understand the important features of the healing process.
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Revealing the role of mechanical factors on bone remodelling: a longitudinal study linking in vivo fatigue loading, advanced imaging and finite element modelling
Principal Investigator
Dr. Wubin Cheng
Mechanical Engineering
Engineering
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Tracey Carr
Co-Investigator(s)
James (Jim) Miller
Joanne Yakowec
Supervisor(s)
Dr. James (J.D.) Johnston (Lead Supervisor) Dr. David Cooper (Supervisor)
2014-2015 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Bone turnover or remodeling, is a lifelong process that involves the ongoing replacement of bone following damage or in response to mechanical forces. Little is known, however, about what specific mechanisms control remodeling. This information is important as it may provide answers to address and cure metabolic bone diseases such as osteoporosis, a debilitating disease typically leading to fracture. The process of remodeling involves bone-resorbing cells called osteoclasts and bone forming cells called osteoblasts. Together osteoclasts and osteoblasts form a basic multi-cellular unit (BMU). The exact mechanisms which control the activities of BMUs are largely unknown, but are thought to be related to mechanical strain (deflection) and/or interstitial fluid flow through bone. Unfortunately, it is difficult if not impossible, to quantify cellular-level strain and fluid flow using experimental methods. Computational finite element modeling (FE), however, is capable of simulating both of these metrics. The overall goal of Dr. Cheng's research is to identify the exact mechanical-regulating factors affecting BMU activity. In this study Dr. Cheng will develop an FE model of the rat ulna using computational modeling, experimental mechanical testing, and advanced imaging at the Canadian Light Source synchrotron. Using this model in combination with an ongoing in vivo fatigue loading study (of rat ulnae), the research will investigate the role of mechanical strain/fluid flow on BMU activity. The results should identify mechanical regulating factors affecting bone turnover.
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Research Showcase 2014
Principal Investigator
Ms. Julie DeGroot
Research & Health Information Services
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Tracey Carr
Co-Investigator(s)
Michelle McCarron
Erwin Karreman
Jennifer St.Onge
2014-2015 Research Connections Grants
Two year
FUNDING RECEIVED
$5,000SHRF
Description
Research Showcase is an annual research sharing and networking event, hosted by the Research Department of the Regina Qu'Appelle Health Region (RQHR). Every year, this event draws together a diverse gathering of participants including health and science researchers, policy makers, clinicians, physicians, students, and the general public in order to highlight research conducted within the region over the past year. The relevance of the event and engaging discussions surrounding the application of research into practice and policy draws an increasing number of participants every year. This year Research Showcase will take place on June 23rd at the Delta Hotel in Regina. Participants can register for the event at http://fluidsurveys.com/s/research-showcase-2014-registration/.
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Developing a Point-of-Care Diagnostic Platform for Antibiotic Resistant Bacterial Infections in Saskatchewan
Principal Investigator
Dr. Jo-Anne Dillon
Bacterial Vaccine Development
VIDO-Intervac
University of Saskathewan
Co-Principal Investigator(s)
Dr. Tracey Carr
Co-Investigator(s)
Rajinder Parti
Anthony Kusalik
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Saskatchewan experiences the highest rates of infection for Neisseria gonorrhoeae (Ng), a sexually transmitted infection (STI), compared to all other Canadian provinces. Ng infections are responsible for significant economic loss due to illness and disease complications of the reproductive tract, especially in women (e.g. infertility, ectopic pregnancy, foetal death). Ng infections are linked to the spread of other STIs including the Human Immunodeficiency Virus. There are no vaccines against Ng and infections can only be cured by treatment with antibiotics. Sadly, Ng isolates can be resistant to all antibiotics and infections may soon be untreatable. The identification of antibiotic resistant Ng isolates requires culture of the microorganism. Over 85% of Ng infections in Saskatchewan are diagnosed by molecular methods where culture is not possible; therefore, antimicrobial resistance (AMR) cannot be ascertained. To combat the development of AMR in Ng, there is a need to identify Ng and its AMR rapidly and simultaneously when a patient seeks health care. Currently no such method/test (called a point-of-care test -POCT) exists. The researchers have designed unique molecular methods that can detect both Ng and its AMR determinants to 5 classes of antibiotic. This study will evaluate the method in a clinical context to diagnose Ng from 200 specimens collected at the Saskatchewan Disease Control laboratory (SDCL); apply and evaluate the methods for specific AMR detection on 100 cultured Ng specimens from the SDCL with known AMR profiles; determine the burden of AMR in Ng non-cultured specimens in Saskatchewan using our DNA-based diagnostics and to compare this burden with results from culture-based testing; and test the predictive values of the DNA-based diagnostics for the development of a commercial POCT for Ng and its AMR. This project, the first of its kind in Saskatchewan and Canada, promises to significantly impact the health care approaches provided to provincially, provincial health policy and diagnostic capacity and international health care.
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The Built Environment and First Nations Health: Addressing & Redressing the Issues. Establishing a Blueprint for Canada
Principal Investigator
Dr. James Dosman
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Tracey Carr
Co-Investigator(s)
Shelley Kirychuk
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$7,000SHRF
Description
“The Built Environment and First Nations Health: Addressing & Redressing the Issues. Establishing a Blueprint for Canada” is a one-day Symposium focused on knowledge exchange and development of future directions for community-level and policy-level action on First Nations health as it relates to housing and environments. Participants will engage in round-table discussions on various topics based on presentations from the CIHR-funded, Saskatchewan-based “First Nations Lung Health Project” and other projects being done in Canada. With input and insights from health care practitioners, community partners, elders, policy makers, researchers, students, local First Nations governing bodies, national government representatives, First Nations housing corporations, and other interested individuals, our aim is to develop a blueprint for action in the area of First Nations housing and health. The Symposium will be held on Tuesday, October 21, 2014 at the Sheraton Cavalier Hotel in Saskatoon, SK. Please email lynette.epp@usask.ca for more information or to register.
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Nutrition Inequity in the Inner City: Using Smartphones to Study Diet and Food Access
Principal Investigator
Dr. Rachel Engler-Stringer
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Hassanali Vatanparast
Nathaniel Osgood
Nazeem Muhajarine
2014-2015 Collaborative Innovation Development Grant
One year
FUNDING RECEIVED
$40,000SHRF
Description
We have seen major advances in the last two decades in the field of community and public health nutrition. In spite of these advances, nutritional health inequalities continue to grow, and non-communicable disease rates continue to climb, which is threatening the health, economic, and social wellbeing of Canadians. Over a four-month period, this research will examine detailed eating and food procurement practices of 40 individuals from diverse household composition types living in the lowest-income neighbourhoods in Saskatoon. The study will use quantitative smartphone-based surveys, location, activity and proximity data collection. The researchers will employ the iEpi system, which has been successfully demonstrated to provide insight into contagious and non-contagious diseases by providing minute-level telemetry on when and where individuals might be exposed to pathogens. Also, iEpi will be used to understand where, when, how, and with whom individuals in lower income neighbourhoods access food and make food choices. This innovative and comprehensive study will make a significant contribution to advancing knowledge in population health interventions in the area of nutrition inequities.
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Food Environments in Canada: Symposium and Workshop
Principal Investigator
Dr. Rachel Engler-Stringer
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Nazeem Muhajarine
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$10,000SHRF
Description
The Food Environments in Canada: Symposium and Workshop will be held in Saskatoon from May 21 -23, 2015. The goal of this symposium and methodological workshop is to bring together researchers, students and practitioners to discuss completed and on-going studies along with the distinct strengths and challenges of Canadian food environments research, and to strategize for how to move this research forward in the future. Many researchers have voiced the need for more Canadian-specific discussions of food environments. This symposium and workshop will provide the time and place for these discussions to happen, leading to new collaborations and initiatives. Registration information will be available on the smartcitieshealthykids.com website.
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Changing Inner City Food Environments: Interventions to Address Nutritional Health Inequities
Principal Investigator
Dr. Rachel Engler-Stringer
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Sylvia Abonyi
Sylvia Barton
2014-2015 Population Health Intervention Research
One year
FUNDING RECEIVED
$200,000SHRF
Description
We know that food choice is influenced by social and physical environments, and that these environments vary, contributing to growing differences in nutritional health across population groups. It is time for research to go beyond describing these differences to providing insight into programs and policies that improve nutritional health. We propose to examine household food practices in a series of low-income inner city neighbourhoods, in the context of numerous community-based food interventions geographically located in the area that aim to address both the social and physical environments. We have chosen an innovative research design that uses interviews, observations, photos and videography to collect in-depth information on the food practices of participating families. We will build on our on-going research on food environments and a grocery store intervention in the inner city. This study will allow us to understand how families access the food they need in urban environments where healthy food access is limited. This project will be conducted by a group of researchers in close partnership with community groups in a way that achieves a positive impact for the people in the neighbourhood. The project has strong support from community agencies and the Saskatoon Health Region.
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Dog Days 2: Furthering Sharing of Sustainable Animal Management Ideas for Healthy First Nations Communities
Principal Investigator
Dr. Tasha Epp
Western College of Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Sylvia Abonyi
Sylvia Barton
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$3,000SHRF
Description
In May 2012, the “Dog Days: Sharing Sustainable Animal Management Ideas for Health First Nations Communities” event was held. It was open to all Saskatchewan First Nations communities for discussions on dog issues and solutions from their own perspectives. "Dog Days 2" hopes to further promote discussions between the stakeholders (communities, academia, public health, and the veterinary profession) on sustainable animal management options. With continued dialogue, research collaborations or solution-based partnerships can be developed with long-lasting impacts on the health of animal and human individuals in these communities, or the overall health of the whole community. Based on the success of the first event, we expect up to 60 participants to attend the 2 day event at Wanuskewin Heritage Park on May 20-21, 2014.
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The role of the PLC delta1 isoform in the osmotic regulation of vasopressin release from supraoptic neurons
Principal Investigator
Dr. Thomas Fisher
Physiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Sean Mulligan
Kiyoko Fukami
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
The body regulates body fluid balance by mechanisms that we are aware of (e.g., thirst) and not aware of (e.g., regulation of the volume and saltiness of our urine). The regulation of urine production is central to the control of body fluid balance, and is controlled primarily by the release of the hormone vasopressin from special neurons in the brain called MNCs, to act on the kidneys to decrease urine production. The release of vasopressin depends on the electrical activity of these MNCs, which increases as the saltiness of the blood increases. We do not fully understand how the MNCs sense changes in blood saltiness. In addition, when we have increases in blood saltiness that last a long time, MNCs grow in size dramatically. This is thought to be important in allowing the MNCs to release high levels of vasopressin for long periods of time. We have discovered a molecular switch, an enzyme called phospholipase C, that is turned on by saltiness and that might be important for both making the MNCs more active and for triggering the increase in MNC size. The objective of this project is to understand how this molecular switch acts on the MNCs and to determine how important the switch is for body fluid balance when animals are prevented from getting sufficient water. This is an important clinical problem in the elderly, in the chronically ill, and in patients taking certain types of drugs, and the researchers hope that their work will eventually contribute to better ways to manage this problem in patients in Saskatchewan and elsewhere.
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The impact of chronic inflammation and its treatment on determinants of health in women with inflammatory bowel disease and their offspring
Principal Investigator
Dr. Sharyle Fowler
Gastroenterology
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Jennifer Jones
Janet Hill
Jane Alcorn
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Very little information exists concerning the effects of chronic inflammatory conditions and the medications used to treat them during pregnancy and lactation on maternal and fetal/infant outcomes. Inflammatory bowel disease (IBD) is a disease that can affect patients during childbearing years. Poorly controlled IBD can have a negative impact on fertility and, should pregnancy be achieved, the unborn child. Therefore, appropriate management of IBD during pregnancy has important consequences for the mother, but can also have both immediate and long-term consequences for her offspring. Dr. Fowler will conduct her research within the established infrastructure of the Saskatchewan Multidisciplinary IBD Clinic to establish a patient registry housing both clinical data and biological specimens from pregnant and lactating women with IBD and their offspring. This patient registry will help answer the multitude of outstanding issues regarding the care of IBD patients during pregnancy and lactation to determine how IBD and IBD treatments affect determinants of health status. Our study objectives are to: 1) Improve the accessibility, quality, and safety of health services for IBD patients in Saskatchewan; 2) Characterize the vaginal microbiome in pregnancy and IBD and assess correlations with outcomes; and 3) Assess the effect of IBD/IBD therapies on breast milk micronutrients.
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Increasing Early Childhood Educator Self-Efficacy to Promote Physical Literacy and Physical Activity Among Children in Rural Childcare Centres
Principal Investigator
Dr. Amanda Froehlich Chow
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Jennifer Jones
Janet Hill
Jane Alcorn
Supervisor(s)
Dr. Louise Humbert (Lead Supervisor)
2014-2015 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
The majority of early years children (0-5 years) are not active enough to receive health benefits and are increasingly taking part in sedentary activities. The early years presents a unique window of opportunity to establish physical literacy and positively influence the health of children. Since many young children spend most of their day in childcare centres, early childhood educators can have a large influence on promoting physical literacy and physical activity. The primary goal of Dr. Chow's study is to implement and evaluate an intervention aimed at increasing educator self-efficacy to promote physical literacy in rural childcare centres. Approximately 30-40 educators and 60-80 children from eight rural childcare centres in Saskatchewan will participate in this study. Educators from four centres will receive a 10-month intervention. They will learn how to perform and teach fundamental movement skills like throwing, catching and leaping. Educators and children in both groups will be tested three different times. Measurements will test educator's self-efficacy using a combination of questionnaires and interviews, physical activity levels of educators and children using accelerometers, and children's physical literacy using a test of gross motor development. The childcare centre environment will also be assessed. The findings of this study will provide evidence about the feasibility and effectiveness of a new, educator-focused intervention to promote physical literacy in early years children specifically in rural childcare centres. Its ultimate goals are to support healthy development among early years children in rural communities and to provide a foundation for a lifetime of being active.
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Optimizing dendritic cell immunotherapy for asthma
Principal Investigator
Dr. John Gordon
Division of Respirology, Critical Care and Sleep Medicine
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Sylvia Van den Hurk
Donald Cockcroft
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$20,000SHRF
$20,000The Lung Association of Saskatchewan
$40,000Total
Description
Asthma affects 10-20% of Canadians, and cost us about $600,000,000 per year, but it is disproportionately prevalent in rural Saskatchewan. Our bronchodilator and steroid treatments address the symptoms of asthma, but not its underlying cause, which is aberrant immune responses to otherwise innocuous environmental agents (e.g., pollen). Allergic immune systems attack these as if they were dangerous, while the remaining 80% of the population treat them as innocuous factors that will not harm us. We need therapies that replace allergic responses with healthy or ‘tolerance' responses. The cells responsible for activating allergic responses (dendritic cells; DC) can also sometimes activate tolerance. The researchers have found that different types of DC induce different kinds on tolerance, with some more resistant to inflammation than others. The purpose of this grant is to critically assess the best protocols for generating treatment DC for asthmatic subjects, as determined using DC and allergic cells from asthmatic donors in a living system.
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Shared Decision Making in Early Stage Breast Cancer: The Development of a Culturally Competent Conceptual Framework Applicable for Aboriginal Patients.
Principal Investigator
Dr. Gary Groot
Surgery
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kevin Stanley
Co-Investigator(s)
Sylvia Abonyi
Linda McMullen
Gary Teare
Mary Hampton
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Shared decision making (SDM), defined as a process by which a healthcare choice is made by practitioners together with a patient, is thought to improve the effectiveness of clinical decisions. The SDM models currently used in clinical practice are based on western concepts and Eurocentric philosophical foundations potentially limiting their relevance and application to aboriginal populations. The goal of this project is to improve the effectiveness of clinical decision making in aboriginal populations and develop a culturally competent shared decision making model for aboriginal patients that is relevant and sensitive to their cultural context. The research aims to understand the underlying philosophical foundations, cultural values and beliefs that inform current SDM theories and models; explore, in collaboration with aboriginal stakeholders, the limitations of current SDM approaches; and identify the differences between western and aboriginal understandings and practices of decision making. Decision making in early stage breast cancer will be used as the clinical issue requiring decision, because it is a common and significant clinical problem for which there are two equally viable treatment options (lumpectomy and radiation versus mastectomy). This pilot project will produce an understanding of how aboriginal persons prefer to make significant decisions and the extent to which these processes are identified in current SDM models.
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In vivo and in vitro evaluation of patient-derived breast cancer cells for early detection and treatment of drug resistant tumors
Principal Investigator
Dr. Troy Harkness
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
Gary Groot
John Gordon
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Breast cancer is a global problem for women. Approximately one in eight women will face breast cancer, and approximately 25% of women receiving antihormone therapy will return to the clinic within 15 years with a recurrent, untreatable multiple drug resistant (MDR) form of the disease. Unfortunately, diagnosis of MDR cancer can only occur upon clinical presentation. The researchers hypothesize that early detection of MDR cancer prior to clinical presentation, and the reversal of MDR protein markers will provide novel and viable treatment options for women suffering recurrent tumors. The researcher's lab has recently discovered that the widely prescribed anti-diabetic drug metformin (MET) renders MDR cancer cells sensitive to chemotherapy by reversing the expression of critical protein markers of MDR. A dramatic recent development in preclinical cancer research will allow the researchers, for the first time, to test whether MET can reverse MDR markers in patient breast tumor samples. The purpose of the study is to generate the preliminary data required for successful applications to CIHR, with a long-term goal to provide hope to women suffering from MDR breast cancer.
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Spotlight on Research: Alzheimer's Disease and Related Dementia
Principal Investigator
Mrs. Marni Hatcher
Alzheimer Society of Saskatchewan
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
Gary Groot
John Gordon
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$5,000SHRF
Description
The Spotlight on Research event is an opportunity for health care professionals, Alzheimer Society clients and the general public to learn more about Alzheimer's disease and related dementias and to hear about leading innovative Alzheimer's disease and related dementia research taking place in Saskatchewan. The event, being broadcast from City Hospital in Saskatoon on January 27, 2015, with anticipated delivery to over 30 sites province-wide using Telehealth technology.The presenter for the evening will be Dr. Darrell Mousseau, Research Chair in Alzheimer's Disease and Related Dementias. Dr. Mousseau will provide a brief description and update of his five-year project to study the link between Alzheimer's disease and depression.
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Nesfatin-1 Integration of Reproduction and Metabolism
Principal Investigator
Dr. Azadeh Hatef
Veterinary Biomedical Sciences
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
Gary Groot
John Gordon
Supervisor(s)
Dr. Suraj Unniappan (Supervisor)
2014-2015 Research Fellowship Top-up Incentive Award
Two year
FUNDING RECEIVED
$20,000SHRF
Description
Reproduction requires energy. Therefore energy intake, metabolism and reproduction are very closely linked. Several hormones are involved in the regulation of metabolism and reproduction, and defects in the production of some hormones and/or there actions can result in reproductive and metabolic dysfunctions. Recent research has found nesfation-1 to be a novel hormone that regulates various aspects of metabolism and some pituitary hormones that regulate reproduction. The understanding of nesfatin-1's role on reproduction, however, is in its infancy. Dr. Hatef's research aims to explain the role of nesfatin-1 in regulating reproductive functions. Dr. Hatef's research has three aims: 1) study nesfatin-1 in the brain, pituitary, and gonads (testis and ovary) of normal, diabetic and obese mice; 2) test the effects of nesfatin-1 in regulating hormone synthesis and secretion in those brain, pituitary and gonads of mice, and; 3) compare results against mice that lacks nesfatin-1 (due to deletion of the gene encoding nesfatin-1). The outcomes of the research will provide significant new information on the role of nesfatin-1 in diabetes and obesity.
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Brain Channelopathies -Target Validation and Novel Therapeutic Strategies
Principal Investigator
Dr. John Howland
Physiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
Gary Groot
John Gordon
2014-2015 W. Garfield Weston Foundation - Brain Canada Multi-Investigator Research Grant
Three year
FUNDING RECEIVED
$75,000SHRF
$165,000Brain Canada
$75,000U of S
$315,000Total
Description
The entry of calcium ions into cells is mediated by a class of protein (called calciumchannels) that responds to electrical signals by opening of a calcium-selective pore.Calcium channels are involved in a large number of physiological processes includingmuscle contraction, hormone secretion and nerve cell communication in the nervoussystem. These physiological processes each require optimal amounts of calcium andalteration of the precise amounts can be highly detrimental. In this proposal we willstudy brain disorders that result from small genetic alterations in calcium channel genesexpressed in the nervous system. One of these alterations causes a severe form ofmigraine headache, another underlies a common type of epilepsy and a third results ina multi-system disorder that includes autism. Further, we will examine a particularcalcium channel genetic change that is found in population studies to be stronglycorrelated with schizophrenia and bipolar disorders.While drugs have been developed to regulate a certain type of calcium channel in thecardiovascular system and are widely used to treat hypertension and heart failure, asyet there have not been specific treatments developed to target calcium channelsinvolved in diseases of the nervous system. To both address this important therapeuticissue and to help determine how the different genetic alterations in calcium channelgenes affect brain functioning, we will test a number of newly developed technicalstrategies aimed at regulating calcium channel activity.The research team has expertise across a broad area of the neurosciences andtogether with utilizing animal models of the calcium channel disorders, we aim toprovide new insights into how particular genetic alterations affect calcium channelproperties resulting in the disruption of normal brain functions and causing seriousdiseases of the nervous system.
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Cannabidiol in Children with Refractory Epileptic Encephalopathy: A Phase 1 Open Label Dose Escalation Study.
Principal Investigator
Dr. Richard Huntsman
Pediatric Neurology
Pediatrics
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
Jose Tellez-Zenteno
Richard Tang-Wai
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$28,600SHRF
Description
The Epileptic Encephalopathies are a group of epilepsies with onset in childhood, characterized by frequent and difficult to control seizures as well as cognitive and neurological impairment. In many patients with these Epileptic Encephalopathy Syndromes, seizures are very difficult to control, despite patients being placed on multiple anti-seizure medications. Since the existing available treatments are of limited benefit, and often cause significant side effects, there is a need to find therapies that are effective and better tolerated for children with epileptic encephalopathies. Recent reports in medical and social media have turned attention to medical marijuana products for the treatment of seizures in children with Epileptic Encephalopathies. The study will assess the safety and tolerability of a Health Canada approved high CBD: low THC product in children with difficult to control Epileptic Encephalopathy. Children enrolled in the study will be given increasing doses of the high CBD: low THC product while being closely monitored for potential side effects and interactions with their current anti-seizure medications. In addition, the study will monitor the effect of this compound on the child's quality of life and seizure frequency.
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History of Exposure to Traumatic Stress and Health Care Experiences
Principal Investigator
Dr. Bridget Klest
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
Jose Tellez-Zenteno
Richard Tang-Wai
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$119,891SHRF
Description
People with a history of being exposed to trauma, particularly interpersonal trauma perpetrated by someone known to them, often deal with many negative health outcomes. Trauma exposure can impact how we function in our interpersonal relationships and impact our trust in individuals and institutions. Trust in physicians, for example, has been associated with better adherence by patients to their recommended care. Health behaviour can be one of several mechanisms that explain the association between trauma exposure and poor health. However, a direct relationship between trauma exposure and mistrust of health care providers and systems has never been established.Dr. Klest's research project aims to determine whether a history of trauma exposure is associated with more negative views of health care providers and systems. Included in the project is the development of a questionnaire that will assess health care experiences of trauma-exposed individuals.Gaining a better understanding of this link could be a necessary step in developing interventions that target individuals with trauma histories, their healthcare providers/systems, or both. The research will consist of three related studies. The first will be an online survey that uses currently available questionnaires to assess associations between the history of trauma exposure and the perceptions of medical providers and medical systems. The second will involve contacting a sample of participants from the first study for in-depth interviews about health care experiences. The third study will use information from the first two studies to develop a questionnaire that assesses trauma-relevant aspects of health care experiences.
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4th Western Canadian Medicinal Chemistry Workshop (WCMCW)
Principal Investigator
Dr. Edward Krol
Pharmacy
Pharmacy & Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
David Palmer
2014-2015 Research Connections Grants
Three year
FUNDING RECEIVED
$5,000SHRF
Description
The Western Canadian Medicinal Chemistry Workshop was developed to facilitate research in the pharmaceutical sciences, primarily between researchers in Western Canada with the goal of improving biomedical research in Saskatchewan and Western Canada, and to provide training and career development opportunities for postdoctoral, graduate and undergraduate researchers in the pharmaceutical sciences. The WCMCW has been held every 2 years since 2008, the 4th WCMCW will be held September 26-28, 2014 at the University of Saskatchewan. Attendees at previous WCMCW have come from Western Canadian universities including, Calgary, Alberta, Lethbridge, Manitoba, Brandon, Winnipeg, British Columbia and Saskatchewan.
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An investigation of personal exposure monitoring and environmental exposures in relation to rural areas and asthma among children
Principal Investigator
Dr. Joshua Lawson
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
George Katselis
Donna Rennie
Shelley Kirychuk
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$20,000SHRF
$20,000The Lung Association of Saskatchewan
$40,000Total
Description
Asthma is one of the most common childhood conditions with a prevalence of approximately 10% globally, and up to 21% in Saskatchewan. Several studies have suggested that farming or rural exposures are protective of asthma, the reasons for which are unknown with one explanation being environmental. However, these same exposures may exacerbate asthma among those with the condition. As part of an ongoing research program investigating childhood in Saskatchewan, the researchers will investigate two new lines of inquiry as they prepare for future grant applications. The first will be the identification of constituents in dust and quantify their relationship with asthma and asthma related outcomes. The second new line of inquiry will be the assessment of personal monitoring as a way of collecting dust samples. The research program is based on a recent cross-sectional survey of approximately 3,400 Grade 1 to 8 children in Saskatchewan who lived along an urban-rural gradient including children living in Regina, Prince Albert, and the rural area around Prince Albert. For the proposed research, the researchers will investigate the associations between the environmental exposures with asthma and related outcomes as well as assess the practicality of personal exposure monitoring of children, the qualitative differences in the dust constituents between the personal and floor samples, and the differences in the associations between the source of monitoring and health outcomes (asthma and asthma morbidity indicators).
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Development of an international research initiative in childhood asthma
Principal Investigator
Dr. Joshua Lawson
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine and CCHSA
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Terra Arnason
Co-Investigator(s)
Darryl Adamko
Donna Rennie
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$8,000SHRF
Description
The objectives of this activity are to disseminate progress from an international childhood asthma research and education initiative and to identify future research directions for this program. This will be completed through two days of research team meetings preceding the 7th International Symposium: “Safety and Health in Agricultural and Rural Populations: Global Perspectives” to be held in Saskatoon October 19-22, 2014. Research team members will also participate in the Symposium including a session on childhood asthma. These events will be aimed at scientists, clinicians, community decision makers, and students. Registration for the Symposium can be completed on-line at: http://cchsa-ccssma.usask.ca/sharp2014/registration.php.
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Breast Health Care in Saskatoon and Saskatchewan: Developing a cutting-edge research base infrastructure to assess reach, appropriateness and outcomes
Principal Investigator
Dr. Anne Leis
Community Health & Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Leanne Smith
Co-Investigator(s)
Gary Groot
Christine Meier
Pamela Meiers
Joan Santoro
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
The use of health information technology has been lauded as one means to enhance patient care and streamline services, while creating opportunities for ongoing data analysis, thereby permitting frequent evaluation of services. Similarly, a rapid learning organization (RLO) is considered a gold standard in health service provision and entails collecting and learning from data, allowing for continuous improvement of care. In Saskatoon, the Breast Health Centre (BHC) has been operational for two years and brings together a multidisciplinary team of providers (surgeons, physicians, nurses and allied health workers) to deliver a coordinated approach to breast health. Presently, patient intake data is collected via paper and pencil format, placed in the patient chart and not readily available for analysis. However, other centers in Canada are moving to patient-driven electronic data entry, which could also include collection of patient reported outcomes. The purpose of this project is to undertake the initial steps to become a RLO through the evaluation of current data and data collection strategies, and to pilot-test a patient-driven electronic data entry approach. Feedback from patients and interested parties will be solicited throughout the study and from the patient representative on this project. Findings from this pilot-work will establish a solid basis for a grant application to the Canadian Breast Cancer Foundation (application 2015) to study how the BHC becomes a RLO, to strengthen Saskatchewan-based research and make Saskatchewan a leader in breast health.
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Ex Vivo Kidney Perfusion under Normothermic Condition for Graft Preservation and Assessment before Implantation
Principal Investigator
Dr. Yigang Luo
Surgery
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Leanne Smith
Co-Investigator(s)
Rahul Mainra
Henry Gauvreau
Michael Moser
Tamalina Banerjee
Raelene Petracek
Mark Rosin
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Often we wish that we could preserve kidney graft lengthily in order to assess/optimize kidney graft function before implantation (i.e. make unusable/suboptimal grafts recover and become suitable for transplantation). Traditionally kidney graft in cold 4°C solution could only be safely preserved for 24 hours, and provide no means of pre-implantation kidney function assessment/optimization. Normothermic preservation has been successfully used to preserve suboptimal lung grafts in human, providing opportunity for assessment and re-conditioning before transplantation. However, it has not be used in kidney graft for the purpose of prolonged preservation and assessment before implantation. The purpose of this study is to establish a novel method to reliably preserve, assess and optimize kidney graft, and its function in the close- to-normal functioning condition before implantation, and thus to enhance donor number increase and improve kidney transplantation outcome. The research objectives are to compare normothermic perfusion with cold machine perfusion and confirm the advantages of normothermic perfusion in prolonged preservation and functional assessment; establish an excellent background to apply for the national kidney foundation research fund; and take this project in large animal as a pre-clinical exercise to introduce clinical normothermic preservation in kidney transplantation.
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Global Health Conference with the title:" Immigrant and Refugee Health: perspectives and pathways"
Principal Investigator
Dr. Ryan Meili
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Leanne Smith
Co-Investigator(s)
Louise Buhler
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$5,000SHRF
Description
A Global Health Conference entitled "Immigrant and Refugee Health: perspectives and pathways" will be held on October 4, 2014 in the Health Sciences Building at the University of Saskatchewan.The conference objectives are to: 1) raise awareness, provide information and share experiences on a wide range of issues that impact the health and well-being of immigrant and refugee populations, locally and globally, 2) engage in discussion and analysis of approaches, practices and policies tnat optimize the health of immigrants and refugees, 3) showcase current immigrant and refugee health related research studies and initatives, 4) provide skill-builidng in culural sensitivity and intercultural communication, 5) faciliate networking opportunities among disciplines and between the University and the community.The conference anticipates about 200 -250 participants, mostly UofS researchers, faculty, students as well as community members engaged in working with immigrants and refugees. A conference website www.saskglobalhealth2014.usask.ca will provide registration information.
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Walking away from low back pain: One step at a time
Principal Investigator
Dr. Stephan Milosavljevic
Physical Therapy
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Ms. Leanne Smith
Co-Investigator(s)
Brenna Bath
Catherine Trask
Erika Penz
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$119,889SHRF
Description
Chronic low back pain (CLBP) is a highly prevalent and expensive health issue. Eighty percent of the population will describe being afflicted to some degree by lower back pain sometime in their life. About 20 per cent will develop CLBP which contributes disproportionally to Canada's $12 billion in health related costs for lower back pain issues. The prevalence of CLBP is 30 per cent greater among farmers. It has been found that exercise encourages an active role in health recovery and pedometer-driven walking is an effective motivator in treating a number of chronic health conditions. However, little research has investigated the use of walking as a health strategy for CLBP. Dr. Milosavljevic's research is designed to test the effectiveness of a 12-week walking program compared to an education-only intervention to treat CLBP. The research team will recruit 160 adults with CLBP residing in the Saskatoon Health Region for a 2:1randomized allocation into two groups. Two thirds will participate in the 12-week, pedometer-driven walking program with advice and guidance from a physical therapist; the other third will receive education only. Both groups will undergo a battery of bio-psychosocial tests before and after the 12-week period and then again at six and 12 months. The groups will primarily be compared on change in disability score, health costs, pain levels and activity rating (step count). It is expected that this study will contribute valuable evidence about a simple, cost-effective strategy for managing CLBP that is both clinically guided and self-driven.
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PCWC Symposium 2014
Principal Investigator
Dr. Harpell Montgomery
Social Work
University of Regina
Co-Principal Investigator(s)
Ms. Leanne Smith
Co-Investigator(s)
Oral Robinson
2014-2015 Research Connections Grants
Three year
FUNDING RECEIVED
$5,900SHRF
Description
This 7th biennial symposium of the Prairie Child Welfare Consortium draws together prairie universities, provincial authorities, and First Nations organization to enhance and strengthen education, training, research and policy development related to child welfare service delivery in Canada. The event will be held at the TCU Place in Saskatoon from October 1 to 3, 2014. Under the theme "Celebrating Child Welfare Transformations: Interdisciplinary Practices, Field Education and Research", the event will feature 58 unique presentations, 25 per cent of which will showcase transformations in child welfare from a health perspective. The symposium will enhance the capacities of stakeholders to build more effective systems and to collaborate across disciplines to include the cultural, social, environmental and health statuses of children, families and communities. We are expecting approximately 125 attendees. Participants can register on our website at: http://www.uregina.ca/socialwork/pcpwsymposium/Index.html
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CCNA Team 20: Issues in dementia care for rural and indigenous populations
Principal Investigator
Dr. Debra Morgan
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristen Jacklin
Co-Investigator(s)
Oral Robinson
2014-2015 Canadian Consortium on Neurodegeneration in Aging
Five year
FUNDING RECEIVED
$500,000SHRF
$1,000,000CIHR
$1,500,000Total
Description
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Priority planning for Dementia Research, KTE, and Policy in Saskatchewan
Principal Investigator
Dr. Debra Morgan
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine, Canadian Centre for Health & Safety in Agriculture
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristen Jacklin
Co-Investigator(s)
Julie Kosteniuk
2014-2015 Research Connections Grants
Five year
FUNDING RECEIVED
$10,000SHRF
Description
In partnership with the Health Quality Council the Rural Dementia Action Research (RaDAR) team has conducted the first-ever "gap analysis" of dementia care in Saskatchewan, including a review of international best practices in dementia care, a scan of existing dementia services in the province, and an analysis of administrative health databases in Saskatchewan to examine dementia incidence, prevalence, and patterns of care. The proposed meeting will involve the Knowledge Network in Rural Dementia Care (family caregivers, health care professionals, administrators, policy makers, government, the Alzheimer Society of Saskatchewan, and researchers). The aims of the meeting are to develop research, policy, and knowledge translation and exchange (KTE) priorities from the gap analysis study, and to identify key elements of a renewed provincial dementia strategy in collaboration with stakeholders. Dr. Anthea Innes, Director of the Bournemouth University Dementia Institute, recognized internally for her research in rural dementia care, will present the keynote address. The meeting will be held Oct 21 and 22, 2014 in Saskatoon. Participation is by invitation. For more information please contact Dr. Debra Morgan (debra.morgan@usask.ca).
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SPOR Pan-Canadian Network in Primary and Integrated Health Care Innovations: Management & Operations Grant.
Principal Investigator
Dr. Nazeem Muhajarine
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cory Neudorf
Co-Investigator(s)
Julie Kosteniuk
2014-2015 SPOR Network in Primary and Integrated Health Care Innovations
Five Year
FUNDING RECEIVED
$250,000SHRF
$65,000Saskatoon Health Region
$60,000Health Quality Council
$125,000U of S
$500,000Total
Description
The purpose of this Network grant is to develop a collaborative network of researchers, physicians, community members, and policy-makers that will focus on generating new evidence in primary and integrated health care effectiveness, efficiency and access across the care spectrum.The Saskatchewan team includes individuals from across the province including researchers, physicians, and policy makers who will work together to improve health equity, more specifically in indigenous and rural areas. The focus will be on prevention and how to better provide services to patients across their life spans (early childhood to older adults). The Saskatchewan team hopes to focus on specific signature initiatives that are very strong in this province.The value of having a Saskatchewan Network will allow researchers in different areas to come together to focus on integrating primary health care and social determinants across urban and rural areas, indigenous peoples, as well as provincial and national components. Through our collaboration with not only researchers, but also physicians and policymakers this will allow the network to identify specific issues facing individuals in Saskatchewan regarding their primary care. The development of the SPOR Saskatchewan network comes at an opportune time given the ambitious and far-reaching systemic changes underway in Saskatchewan health care system, in particular relevant to this application, the Lean Initiative and Primary Health Care reform.
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Role of long-chain polyunsaturated fatty acids (PUFAs) in myelination: multidisciplinary approach that combines histological, molecular and synchrotron techniques
Principal Investigator
Dr. Adil Nazarali
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Bogdan Popescu
Co-Investigator(s)
Phyllis Paterson
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
Multiple sclerosis (MS) is a chronic debilitating disease and the major cause of non-traumatic neurological disability in young adults. In MS, the fatty, insulating ‘myelin sheath' surrounding nerve tracts in the central nervous system (CNS) degenerates leading to nerve cell damage and impaired movement / cognition. Alarmingly, Saskatchewan has one of the highest rates of MS globally, and a cure remains elusive. Current therapies focus on anti-inflammatory mechanisms with limited success, which has left many people leaving the province (and country) for costly and highly experimental procedures. There is much speculation about the benefit of a high polyunsaturated fatty acid (PUFA) diet containing omega-6 or omega-3, for MS. There is evidence PUFAs can modulate oxidative stress pathways in the body, but there is a lack of quantitative information on PUFAs impact on oxidation in brain tissue and on myelination efficiency in the mature CNS. The objectives of this research project are to determine whether an omega-3 enriched diet is beneficial against myelin sheath degeneration or promotes myelin repair and determine the feasibility of translating this research to a patient population. This research will establish a foundation for dietary supplementation of PUFAs as a therapeutic tool to protect against and/or repair CNS damage caused by MS.
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Seeing the Light
Principal Investigator
Dr. Helen Nichol
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Bogdan Popescu
Co-Investigator(s)
Ingrid Pickering
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$3,000SHRF
Description
Seeing the Light is an Open House at the Canadian Lightsource (CLS) that will showcase synchrotron-based health research conducted by fellows of the CIHR-THRUST training program. The last CLS open house was 10 years ago and the public response was overwhelming. Registration will be limited to 250 for morning or afternoon sessions (https://fluidsurveys.usask.ca/s/clso/). The event is free of charge and free parking is available. Visitors will go onto the experimental floor for see the equipment used by researchers and to talk to THRUST scholars about their research. All research exhibits, tours and talks will be geared for families.
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Access to Recovery for Saskatchewan People with (Dis)Ability and Substance Abuse Issues: From Needs Assessment to Building Capacity.
Principal Investigator
Dr. Gabriela Novotna
Social Work
University of Regina
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Nuelle Novik
Bonnie Jeffery
Michelle McCarron
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$30,460SHRF
Description
Persons with physical, sensory, and cognitive (dis)ability issues are at considerably higher risk to develop substance abuse problems when compared to the general population. Despite the high prevalence of substance abuse and related health and social consequences that persons with (dis)ability and substance abuse issues experience, research suggests a low utilization of substance abuse treatment by this population. Untreated substance abuse problems in persons with (dis)ability issues not only interfere with successful engagement in their rehabilitation but also contribute to the development of additional health-related problems. In Saskatchewan, providing clinically appropriate and sensitive treatment to special populations, including those with coexisting substance abuse and (dis)ability issues, has been an identified priority with the Ministry of Health. However, little is known about the areas of needed policy and service development in instances where substance abuse and (dis)ability issues intersect. The purpose of this research development project is to identify the research-practice gap in policy and service development related to substance abuse treatment and supports for persons with (dis)ability issues. The research team will provide a synopsis of best practice examples in substance abuse treatment for persons with (dis)ability issues in Canada and internationally. Additionally, a collaborative network with policy makers and planners as well as persons with coexisting (dis)ability and substance abuse issues will be built to identify the needs in the provincial policy and service development and, and inform a future research program that would address the identified needs of persons with coexisting (dis)ability and substance abuse issues.
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Development of novel antimicrobial agents based on inhibitors of diaminopimelate biosynthesis
Principal Investigator
Dr. David Palmer
Chemistry
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
David Sanders
Joseph Rubin
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$40,000SHRF
Description
New classes of antibiotics are urgently needed, because antibiotic-resistant bacteria continue to emerge and represent a looming health crisis. The diaminopimelate (dap) pathway in bacteria is required to synthesize lysine and meso-diaminopimelate, two essential components of the cell wall without which bacteria cannot survive. This project will develop compounds that inhibit the dap pathway, and thereby kill bacteria. Because mammals do not have this metabolic pathway, such compounds can be safely used as drugs. This team and their laboratories have the background and expertise to create promising leads for new antibiotics to fight infections. This work will involve synthesis of novel compounds; the use of computers to "dock" proposed compounds to proteins in order to predict function; assessment of all compounds as antibiotics against many bacteria; and the determination of the structures of drug-target complexes. This project is a new collaboration between University of Saskatchewan scientists in the Department of Chemistry in the College of Arts and Science, and the Department of Veterinary Microbiology, Western College of Veterinary Medicine.
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Research Matters: Facilitating Research Connections
Principal Investigator
Dr. Elan Paluck
Research and Performance Support
Research & Health Information Services
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
David Sanders
Joseph Rubin
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$1,500SHRF
Description
The RQHR Research Department is creating a unique opportunity to facilitate the development and growth of our clinical research teams in Saskatchewan. The second of a series of facilitated events is planned on the evening of June 23rd in the Fireplace Room at Crave Kitchen and Wine Bar in Regina, targeted specifically at RQHR physicians and researchers from the University of Regina and SIAST (Wascana Campus). The objective of this event is to create connections among these clinician scientists and researchers in the effort to identify strategic research priorities, and to develop feasible research teams. These researchers represent a broad spectrum of expertise including: psychology, cardiology, infectious disease, orthopedic surgery, oncology, renal, primary care, medical imaging, sports medicine, among others. We anticipate this event will foster recognition of collaborative research teams, and the intrinsic relationship between producing clinically based evidence and improved patient outcomes.
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Development of an Oral Vaccine Platform for Neonates
Principal Investigator
Dr. Jonathan Pasternak
VIDO-InterVac
VIDO
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
David Sanders
Joseph Rubin
Supervisor(s)
Dr. Heather Wilson (Lead Supervisor)
2014-2015 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Vaccines are the most effective tools for the control of infectious disease, however, their use in combating intestinal infection and diarrheal disease, which play a key role in childhood development and public health, has yet to be fully realized. The majority of pathogens enter the body through mucosal surfaces such as the intestinal mucosa, where classical vaccinations fail to trigger significant immunity. Oral vaccination not only has the benefit of inducing both mucosal and systemic immunity but avoids the need for both needles and health professionals for administration. A small number of whole-agent oral vaccines (live-attenuated virus) have been brought to market but a safe and effective oral subunit vaccine remains elusive. This is likely owing to minimal transport across the gut wall and a tendency for the body to respond to oral antigens with tolerance instead of immunity. The intestine of the neonate however, is unique. It is maintained for a short time in a “leaky” state to allow the passive transfer of maternal antibodies into the bloodstream. This project seeks to develop an oral subunit vaccination platform by capitalizing on this unique physiological state. Using swine as a large animal model, we intend to evaluate the transit and immunogenicity of the protein ovalbumin (an academic antigen) and relate this to the permeability of the neonatal gut over time. Dr. Pasternak's team will use Eshericia coli (E.coli) proteins as vaccine antigens, deliver them to neonates using dose/timing identified as optimal using ovalbumin, then establish the immune response and protection against diarrhea.
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A psychosocial intervention for bereaved spousal caregivers of persons with dementia: Adapting the “Finding Balance” tool
Principal Investigator
Dr. Shelley Peacock
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Lorraine Holtslander
Megan O'Connell
Genevieve Thompson
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$87,096SHRF
Description
As baby boomers age, the number of people with dementia is rapidly increasing. The progressive cognitive impairment that often results from dementia requires a great deal of support from family caregivers. There has been little research conducted regarding the bereavement experience in the dementia caregiving journey and few interventions exist to support bereaved dementia caregivers. Dr. Peacock's study aims to adapt the psychosocial intervention called “Finding Balance” to support bereaved spousal caregivers of patients with dementia. This self-administered writing tool was originally developed for bereaved older adult spousal caregivers of persons with cancer; however, the notion of finding balance has the potential to also work for bereaved dementia caregivers.The research will: explore the bereavement experience of dementia spousal caregivers; consult with experts using emailed surveys regarding the needs of bereaved caregivers; use information gathered to adapt the “Finding Balance” tool to the dementia context; pilot-test the adapted tool; and evaluate the tool's benefit in the dementia journey.Seniors are a rapidly growing population in Saskatchewan and healthy aging is a system health priority. With increased age comes a greater risk of developing dementia and many of the spouses who are often the caregivers are seniors themselves. Dr. Peacock's project will begin addressing the gap in the research regarding the bereavement experience in dementia, as well as offer a cost-effective and convenient intervention.
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Assessing quality of care for patients with inflammatory bowel diseases (IBD) and evaluating the impact of the Multidisciplinary IBD Clinic in Saskatchewan: a population-based cohort study using administrative data
Principal Investigator
Dr. Juan-Nicolas Pena-Sanchez
Division of Gastroenterology, Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Lorraine Holtslander
Megan O'Connell
Genevieve Thompson
Supervisor(s)
Dr. Lisa Lix (Supervisor) Dr. Jennifer Jones (Supervisor) Dr. Gary Teare (Lead Supervisor)
2014-2015 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$50,000SHRF
$50,000Crohn's and Colitis Canada
$100,000Total
Description
Crohn's and Colitis Postdoctoral Fellow, co-funded by Crohn's and Colitis CanadaInflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic condition potentially causing life threatening complications and impacting the quality of life of patients. Increasing trends of IBD are described and Canada has the highest incidence and prevalence worldwide. Assessments of health care utilization and outcomes for patients with IBD in Saskatchewan are needed to bridge the gaps in knowledge in health care delivery. Integrated models acknowledging the bio-psychosocial dimensions of IBD have the potential to reduce medication use, hospitalization, and health care costs. In 2009, the Saskatchewan Multidisciplinary IBD Clinic was formed and began implementing a patient-centred chronic disease management model.Dr. Pena-Sanchez is aiming to undertake a population-based longitudinal study that uses Saskatchewan administrative billing data from the last three decades to assess the quality of care for patients with IBD and evaluate the impact of the IBD Clinic. The study will measure health care utilization patterns, comparing patients managed within the Clinic to those who are not. In addition, the study will evaluate drug utilization for IBD in Saskatchewan and include an evaluation of women with IBD exposed to biologics and immunosuppressive therapy during pregnancy. This research has the potential to provide a comprehensive assessment of health care quality for patients with IBD in Saskatchewan, identify gaps in health care and the potential impact of the IBD Clinic on quality improvement for IBD.
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Cost Effectiveness of Lung Cancer Screening in Saskatchewan - Applying Microsimulation Modeling and Saskatchewan-specific Costs of Lung Cancer Diagnosis and Management
Principal Investigator
Dr. Erika Penz
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Braden Manns
Donna Goodridge
Gary Teare
Christopher Hergott
Nathaniel Osgood
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$119,817SHRF
Description
Lung cancer is one of the leading causes of cancer deaths in Canada, in part because it is often not diagnosed until very advanced. Lung cancer screening has been suggested as an effective way to identify cancers earlier. Recently, a large study in the United States showed that annual screening with chest CT scan in individuals at high risk for lung cancer reduced lung cancer deaths by 20 per cent compared with chest x-ray screening. As a result, US guidelines recommend annual CT screening for lung cancer in heavy smokers between the ages of 55 and 80.The purpose of Dr. Penz's research is to evaluate the costs and benefits of lung cancer screening in Saskatchewan. The team will also aim to estimate the costs associated with diagnosing and treating lung cancer patients. With the use of modeling, they will predict the costs and lives saved with a lung cancer-screening program compared to no screening. Using Saskatchewan Ministry of Health administrative data, they plan to identify patients diagnosed with lung cancer and calculate the total number of health services and costs they incur over the course of their lung cancer journey from diagnosis, treatment, remission, and/or end of life.In today's world with health system resources stretched, it is important to evaluate whether investment in new programs offers value or not for the money spent. This research study hopes to inform this important health policy issue with the goal of understanding and improving care for individuals with lung cancer.
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Fifth Annual CIHR-THRUST Retreat
Principal Investigator
Dr. Ingrid Pickering
Geological Sciences
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Mercedes Martinson
Isaac Pratt
Ashley James
Sally Caine
2014-2015 Research Connections Grants
Three year
FUNDING RECEIVED
$3,000SHRF
Description
CIHR-THRUST, the CIHR Training grant in Health Research Using Synchrotron Techniques, supports innovative training in health research using the Canadian Light Source synchrotron. Based at the University of Saskatchewan, the training program engages clinical and biomedical health researchers with synchrotron specialists and other scientists and engineers to push the boundaries of synchrotron health research. Our Annual Retreat is the focus of our program year, bringing together the trainees with experts from across the disciplines. This day comprises oral presentations, a poster session for all trainees, and a unique opportunity for synchrotron health research networking and brainstorming.
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The Effect of Tranexamic Acid (TXA) on Ruptured Abdominal Aortic Aneurysms
Principal Investigator
Dr. Jagadish Rao
General Surgery
Surgery
Medicine
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
David Kopriva
Jennifer St.Onge
Michelle McCarron
Suzanne Gulka
Donald McCarville
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$20,756SHRF
Description
An abdominal aortic aneurysm occurs when the part of the aorta travelling down into the kidneys and abdomen balloons out more than 50%. Many of these aneurysms have no symptoms, and go undetected until they rupture, causing large amounts of blood to spill into the abdominal cavity and typically lead to death within minutes. The current mortality rate is between 50% and 90%. Treating patients with ruptured aortic aneurysms requires many blood transfusions and long hospital stays if they survive. To prevent blood loss in elective surgeries, drugs that promote blood clotting are often used. One drug, tranexamic acid, has been shown to reduce blood loss, reduce the number of blood transfusions required, and improve patient outcomes in elective cardiac and orthopedic surgeries, and more recently, in patients with traumatic internal bleeding. However, this drug has not been tested in people with ruptured abdominal aortic aneurysms. The purpose of this pilot study is to evaluate the effectiveness of tranexamic acid in reducing excessive bleeding in patients with ruptured aortic aneurysms in hospital sites across Saskatchewan.
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Protein Function, Structure and Malfunction Symposium
Principal Investigator
Dr. David Sanders
Chemistry
Arts & Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Miroslaw Cygler
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$2,500SHRF
Description
The purpose of the PSFaM conference is to bring together protein scientists and structural biologists from western Canada to present recent findings from their laboratories, to network and meet colleagues, to discuss common interests and goals, and to develop a strong, tightly knit community of protein scientists in Western Canada. Much of the presented research has been performed in part at the Canadian Light Source; the staff of the Canadian Macromolecular Crystallography Facility participates in the organization of this conference. The theme of the meeting is the role of proteins in health and disease.
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Defining clinical relevance of gardnerella vaginalis subgroup B in HIV infection by analysis of molecular systems during co-culture with vaginal epithelial cells
Principal Investigator
Dr. John Schellenberg
Veterinary Microbiology
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Miroslaw Cygler
Supervisor(s)
Dr. Janet Hill (Supervisor)
2014-2015 Research Fellowship Top-up Incentive Award
Two year
FUNDING RECEIVED
$15,000SHRF
Description
The overall purpose of the proposed research is to define clinical relevance of specific subgroups of Gardnerella vaginalis in relation to bacterial vaginosis (BV), a common but poorly understood vaginal condition associated with increased risk for HIV infection and pre-term birth. Since G. vaginalis is also found in healthy women without vaginal symptoms, further work is required to define subgroups in terms of disease-causing characteristics. Our previous work has defined four subgroups of G. vaginalis that may potentially be new Gardnerella species. One subgroup (“B”) has been found to be associated with BV diagnosis and many strains of this subgroup require oxygen-free conditions to grow suggesting that they may have been overlooked in previous studies. Dr. Schellenberg proposes to determine whether women with BV vaginal symptoms or disease recurrence are more likely to be colonized with G. vaginalis subgroup B by screening vaginal samples using subgroup-specific probes. By culturing G. vaginalis isolates from these samples in oxygen-free conditions, he will characterize potential pathogenic factors such as biofilm formation on cultured vaginal cells, growth on vaginal mucus, and production of the enzyme sialidase in comparison with other subgroups. By analysis and annotation of genomes from group B organisms, the research will then define genetic profile and expression of possible disease-causing factors using next-generation molecular techniques. This research will help explain the microbiological basis for an extremely common vaginal condition with high but poorly defined significance for reproductive health, potentially leading to improved detection, diagnosis and treatment of BV.
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Optimizing tolerogenic dendritic cells for immunotherapy
Principal Investigator
Mr. Sachin Singh
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Miroslaw Cygler
Supervisor(s)
Dr. John Gordon (Lead Supervisor)
2014-2015 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
Description
Award declined by recipient
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Prostate Cancer Microparticles as a Next Generation Screening Tool for Prostate Cancer
Principal Investigator
Dr. Jennifer St.Onge
Research & Performance Support
Research & Health Information Services
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Hon Leong
Teralee Burton
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$27,687SHRF
Description
Saskatchewan is the only population in the world that continuously screens for prostate cancer (PCa) in men of all ages using the prostate specific antigen (PSA) blood test. However, the PSA test often incorrectly identifies men as having cancer or detects low-grade cancers that are slow-growing and rarely cause harm. Biopsy and surgical treatment of these slow-growing cancers can cause stress, incontinence, impotence, bowel dysfunction, and pain. PSA screening is no longer strongly recommended by major health organizations, because it does not reduce mortality. Researchers have discovered pieces of tumor cells in the blood of PCa patients (prostate cancer microparticles-PCMPs). These cells can be detected using a brand new blood test. So far, this PCMP test is able to accurately identify men with aggressive PCa in small numbers of men, but we need to use a large screening population, such as Saskatchewan, to see if it will work as a new screening tool. The purpose of this pilot is to use the PCMP test on a small number of samples from patients in Saskatchewan to ensure that the test is successful in identifying aggressive PCa in our population. If the test is accurate at identifying patients with PCa, the researchers will apply for funding from the Prostate Canada Clinical Trials Grant Program for a large clinical trial to better evaluate the use of this test. This pilot study is critical for validating the PCMP test in Saskatchewan patients.
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Simulation-based assessment and experimental evaluation of movement retraining to improve stability during walking
Principal Investigator
Dr. Ian Stavness
Computer Science
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Randy Johner
Co-Investigator(s)
Joel Lanovaz
Alison Oates
2014-2015 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Healthcare costs for fall-related fractures were estimated at almost $200 million in 2013. Falls and fall-related fractures are a health concern especially for older adults and the situation is becoming increasingly critical as Saskatchewan's population ages. For individuals with balance deficits, the body's responses that maintain balance may be diminished or slower. This can be partly compensated for by the built-in or intrinsic stability that accompanies standing and walking. Improving intrinsic stability during walking is a promising way to help prevent falls.Dr. Stavness' research aims to develop a computer simulation tool to identify potential gait modifications that may increase intrinsic stability and then to evaluate the ability of these walking modifications to reduce the negative effects of a slip during walking. The three-dimensional computer simulation tool will identify factors that affect intrinsic stability and develop various walking patterns that could improve balance.The long-term aim of this research is to improve balance and reduce falls among older adults. As a precursor to this, we will validate our simulation tool with young, healthy participants. By basing gait modification therapy on computer simulations and testing these therapeutic possibilities, we expect to provide direct and quantitative recommendations for clinicians to tailor modifications to a patient's specific gait pattern, improving stability and reducing fall risk.
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Transforming Métis Health Services Together: Development of research governance partnerships between Métis peoples and the Saskatoon Health Region
Principal Investigator
Dr. Caroline Tait
Psychiatry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cory Neudorf
Co-Investigator(s)
Peter Butt (Co-Principal Applicant)
Leah Ferguson
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,969SHRF
Description
The goal of this project is to improve research governance, health care policies, and patient-oriented care delivered to Métis peoples of Saskatchewan. To advance this goal, the Métis Nation-Saskatchewan (MN-S) and the Saskatoon Health Region (SHR) have plans to introduce a culturally safe clinical intake tool that allows for self-identification by Métis patients using emergency departments (EDs). Self-identification by Métis patients facilitates the tracking of their use of EDs and their movement through hospital services, including the length of their stay, and the ease of their discharge plan. When amassed, this data can be used to identify barriers and gaps in our health care system that negatively impact Métis patients, contribute to improved patient care, and inform health care policies, training, and services. Partnering with University of Saskatchewan researchers, the MN-S will research and design a research governance model specific to the Métis peoples of Saskatchewan. Over the year of the project, our interdisciplinary team will complete a literature review of Indigenous health research governance models and an environmental scan of research governance models used in the past five years by Saskatchewan Métis communities and organizations. The literature review and the environmental scan will serve as the basis for our team to design a research governance model to be adopted by the MN-S and used in their partnership with the SHR. The research governance model will be piloted in the development and implementation of a multi-year Canadian Institutes of Health Research grant, to be submitted by the MN-S, the SHR and the UofS in 2015-2016.
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7th International Symposium: Safety & Health in Agricultural & Rural Populations: Global Perspectives (SHARP)
Principal Investigator
Dr. Catherine Trask
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cory Neudorf
Co-Investigator(s)
George Katselis
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$10,000SHRF
Description
The symposium, which will be held in Saskatoon, 19-22 October 2014, will capture the impact of global issues and challenges facing the health and safety in agricultural settings in the 21st century. In addition, we have partnered with the Canadian Association for Research in Work and Health (CARWH) and the Canadian Rural Health Research Society (CRHRS), so our scope will include occupational and rural health. Combined with the international attendance, the diversity in symposium's topics will allow for sharing of methods and cross-pollination of the ideas that impact health and enhance Saskatchewan's research capacity and the health of the people of Saskatchewan.
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Saskatchewan Public Health Nutrition Research Network Symposium
Principal Investigator
Dr. Hassanali Vatanparast
School of Public Health
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cory Neudorf
Co-Investigator(s)
Susan Whiting
Rachel Engler-Stringer
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$4,147SHRF
Description
The 2nd Annual Saskatchewan Public Health Nutrition Research Network Symposium: Integrating Research, Policy and Practice aims to promote communication with stakeholders; encourage collaborative and multidisciplinary research; identify the needs in public health nutrition as a field of practice; and initiate programs that build capacity for practitioners. The event will be held October 16-17, 2014 at the Frances Morrison Central Library and Sheraton Cavalier in Saskatoon. Featured are respected keynote speakers Dr. Tim Green and Dr. Shailesh Shukla as well as many Saskatchewan researchers and practitioners in the field. For symposium program and registration information, please visit www.usask.ca/phnr2014
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Mapping the mammalian neurodegenerative disease-associated protein-protein interactome.
Principal Investigator
Dr. James Vlasblom
Chemistry and Biochemistry
Science
University of Regina
Co-Principal Investigator(s)
Dr. Cory Neudorf
Co-Investigator(s)
Susan Whiting
Rachel Engler-Stringer
Supervisor(s)
Dr. Mohan Babu (Lead Supervisor)
2014-2015 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Mitochondria are complex, double-membraned organelles present in all eukaryotes that perform many vital functions including respiration, apoptosis, and metabolism. Mitochondrial function in human beings is primarily mediated by approximately 1,500 nuclear-encoded proteins that must be imported via protein translocases located in the mitochondrial membrane. Mitochondria are essential to a myriad of diverse cellular processes and defects in their function have emerged as causative or contributing factors for a growing number of human disorders and are particularly highly associated with neurodegenerative (ND) diseases. Ad hoc proteomic and genetic studies have uncovered a small number of candidate mitochondrial proteins (MPs) involved in ND disease, but given the diversity of processes affected by MP function, many more likely remain unknown. To further elucidate the function of these proteins, we have curated and are systematically purifying over 130 ND-associated human MPs in neuronal (embryonal carcinoma - Ntera2) and non-neuronal (colorectal carcinoma - HCT116) cell lines using state-of-the-art proteomics procedures, and identifying ND-linked putative interaction partners for each protein. This will enable novel functions to be ascribed to these proteins, and serve as a scaffold to motivate future computational and biochemical studies. Databases of human disease-gene associations will allow us to find and prioritize new disease gene candidates for further experimental follow-up. Dr. Vlasblom's research on the computational aspects of this larger research program will enable new insights into mitochondrial biology, and define a comprehensive, accurate, and valuable resource for the development of novel therapeutics.
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Exploring New Technologies to Support Investigation of Foodborne Disease
Principal Investigator
Dr. Cheryl Waldner
Public Health
Large Animal Clinical Sciences
Western College of Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nathaniel Osgood
Co-Investigator(s)
Kevin Stanley
Wanda Martin
Juxin Liu
Cory Neudorf
Scott Bell
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$39,800SHRF
Description
Studies tracking the source of foodborne outbreaks traditionally involve telephone interviews several days after illness onset, and can be adversely affected by participant recall. This innovative project will evaluate iEpi, the well-established Android smartphone app developed by the researchers. The app is a new technology used for gathering data on food consumption and occurrence of gastrointestinal illness. This pilot study provides a unique opportunity to measure the extent of participant recall bias and the resulting limitation of current investigation strategies. Over a 10 week period, university students will be recruited and asked to report any gastrointestinal symptoms using iEpi, including taking photos and answering questions on daily food intake. Two weeks later, participants will complete an online survey asking them to recall their food consumption history for days 4 to 10. In addition to surveying study participants' experiences with the system, we will conduct a focus group with public health leaders to share the results and obtain guidance on future priorities. This proof of concept study will also examine the feasibility of using iEpi to support investigation of enteric illness, including foodborne disease, and identify hurdles to scaling up the use of iEpi to a larger, more diverse study population. Utilizing lessons for the application of iEpi to foodborne disease, the researchers will investigate larger scale deployments with participant owned smartphones for examining risk factors for enteric illness, including foodborne disease in other environmental contexts, such as communities at risk.
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“Applied Epidemiology for Improving the Health of Communities”
Principal Investigator
Dr. Brandace Winquist
Saskatchewan Epidemiology Association
Co-Principal Investigator(s)
Dr. Nathaniel Osgood
Co-Investigator(s)
Kevin Stanley
Wanda Martin
Juxin Liu
Cory Neudorf
Scott Bell
2014-2015 Research Connections Grants
One year
FUNDING RECEIVED
$3,690SHRF
Description
Symposium: “Applied Epidemiology for Improving the Health of Communities”, Thursday, October 23, 2014Workshop: “Outbreak Investigation: The need for speed!”, Friday, October 24, 2014 The purpose of the Saskatchewan Epidemiology Association's Annual symposium and workshop is to advance the understanding and application of epidemiology through continuing education and network enhancement. This year's SEA Symposium will bring together an exciting mix of epidemiologists, public health practitioners, veterinary health experts, and decision-makers, academics, and students certain to stimulate learning and to generate thought-provoking discussion. Speakers will share their knowledge of current research activities and practices in both animal and human populations that focus on promoting and protecting the health of our communities. Over 100 participants are expected to attend, with a new option to connect virtually. The annual SEA fall symposium is one of Saskatchewan's best opportunities for learning from public health leaders and researchers, sharing best practices, and networking with those studying and working in the field.
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Interprofessional pathways for safe, healthy communities
Principal Investigator
Dr. Philip Woods
Research, Innovation and Global Initiatives
Nursing
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Lorna Butler
Co-Investigator(s)
Janet Luimes
Kelly Stienwand
Jason Stonechild
2014-2015 Collaborative Innovation Development
One year
FUNDING RECEIVED
$18,258SHRF
Description
Police Services are highly visible, professional teams within rural and urban communities that are often tasked with addressing the impact of health inequities with minimal access to support services and resources. In Prince Albert, the Police Services Detention Centre has become a “funnel point” for persons at risk who suffer from health related issues, such as mental health, violence/victimization and addictions. Police officers frequently transport individuals to and from the emergency room for assessment and related care, because health services are not provided at the detention centre. Through an exploratory descriptive research design, a new intervention pathway for detainees will be examined. The goal is to identify and support individuals “at risk” while in custody, and develop a pathway for appropriate assessment, monitoring and follow-up. Using remote presence (RP) technology via an RP-Xpress a Registered Nurse enrolled in the Nurse Practitioner (NP) program will conduct their clinical placement in a jointly administered practicum designed to provide care to individuals who are admitted to the Prince Albert Police Services Detention Centre. The NP student will work collaboratively with the Family Medicine and Emergency Medicine Residency Programs at the Union Hospital in Prince Albert.
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Elucidating human G protein-coupled receptor function through protein and genetic interaction maps
Principal Investigator
Dr. Mohan Babu
Chemistry and Biochemistry
Science
University of Regina
Co-Principal Investigator(s)
Dr. Lorna Butler
Co-Investigator(s)
ZhaoLei Zhang
Nevan Krogan
2013-2014 RPP - Operating Grants
Two year
FUNDING RECEIVED
$156,058SHRF
$156,058CIHR
$312,116Total
Description
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Cancer Systems Biology Group
Principal Investigator
Dr. Mohan Babu
Chemistry and Biochemistry
Science
University of Regina
Co-Principal Investigator(s)
Dr. Lorna Butler
Co-Investigator(s)
Scot Leary
Andrew Freywald
ZhaoLei Zhang
2013-2014 Health Research Group Grants - Phase I
One year
FUNDING RECEIVED
$3,000SHRF
Description
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One Health Imaging (OHI)
Principal Investigator
Dr. Paul Babyn
Medical Imaging
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Rajan Rakheja
Khan Wahid
Haron Obaid
Carl Wesolowski
Clarence Geyer
Humphrey Fonge
2013-2014 Health Research Group Grants - Phase I
Two year
FUNDING RECEIVED
$30,000SHRF
Description
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Perceptions of cognitive health: An ethnographic inquiry of rural older adults
Principal Investigator
Juanita Bacsu
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Rajan Rakheja
Khan Wahid
Haron Obaid
Carl Wesolowski
Clarence Geyer
Humphrey Fonge
Supervisor(s)
Dr. Sylvia Abonyi (Lead Supervisor)
2013-2014 RPP - Doctoral Awards
Three year
FUNDING RECEIVED
$52,500CIHR
$52,500U of S
$105,000Total
Description
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Advancing interprofessional primary health care services in rural settings for people with chronic low back disorders: Investigation of a physiotherapist and nurse practitioner intervention delivered through telehealth
Principal Investigator
Dr. Brenna Bath
Physical Therapy
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Stephan Milosavljevic
Megan O'Connell
Nazmi Sari
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$119,934SHRF
Description
Chronic low back problems are common. They bring considerable pain, limit physical ability, and lower a person's quality of life. About 22 per cent of Canadians report having chronic back problems, but people living in rural and remote areas are up to 29 per cent more likely than urban dwellers to suffer. Although physical therapists have much to offer in the management of back problems, not everyone has easy access to these services especially in rural and remote areas. New models of health care are needed for people with chronic back problems living in rural and remote regions of Saskatchewan who have limited access to local physical therapy services. This research project will evaluate and compare three different health care delivery options available for 90 residents of one rural Saskatchewan community with limited physical therapy services: 1) care delivered by a nurse practitioner; 2) the Telehealth option which connects an urban-based physical therapist with a local nurse practitioner; and 3) face-to-face services by a physical therapist traveling to the community. The study will examine patient outcomes including pain, physical function, quality of life, and satisfaction. The study will also provide an economic evaluation of using Telehealth for management of back problems. By addressing this prominent health issue the research will identify how improved access to physical therapy services in rural and remote areas can help those with chronic back problems. If the outcomes are positive it may provide a model for enhancing health care in other rural communities and for other chronic health conditions.
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Spotlight on Research: Alzheimer's Disease and Related Dementias
Principal Investigator
Ms. Joanne Bracken
Alzheimer Society of Saskatchewan
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Stephan Milosavljevic
Megan O'Connell
Nazmi Sari
2013-2014 Research Connections Grants
Three year
FUNDING RECEIVED
$3,000SHRF
Description
This research awareness event will begin with a reception with Dr. Darrell Mousseau, Research Chair, Department of Psychiatry, University of Saskatchewan and tour of his laboratory. This portion of the evening will be by invitation only with invitations sent to those that have provided financial support for or communicated an interest in research. The invitees will have an opportunity to speak with Dr. Mousseau about his research and receive a guided tour of Dr. Mousseau's laboratory with student researchers present to answer questions.Following the reception and tour, the key presentation by Dr. Mousseau, will be open to the general public. In addition advertising publically, we will be inviting people with dementia, family caregivers, donors and supporters of the Alzheimer Society. Attendance is free, but advance registration to the Dr. Mousseau's presentation is requested by calling 1-306-949-4141 or online at www.alzheimer.ca/sk
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The use of clinical testing procedures in the diagnosis of motor control impairments associated with low back pain
Principal Investigator
Dr. Paul Bruno
Kinesiology and Health Studies
University of Regina
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
John Barden
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$47,692SHRF
$47,692Canadian Chiropractic Research Foundation
$95,384Total
Description
SHRF Establishment Grant co-funded by the Canadian Chiropractic Research Foundation Low back pain is a significant public health problem whose estimated socioeconomic costs are comparable to conditions such as heart disease and diabetes. The use of appropriate motor control strategies is essential in the generation of spinal stability, and low back pain patients have been shown to demonstrate a variety of motor control impairments. Dr. Bruno's research aims to explore the utility of two tests, the Prone Hip Extension test and the Active Straight Leg Raise test used by physical medicine and rehabilitation clinicians to examine the motor control strategies used by low back pain patients.The research project has two objectives: 1) To objectively quantify the lumbopelvic motion patterns and muscle activation patterns demonstrated by low back pain patients during the tests and assess the ability of these patterns to distinguish low back pain patients from healthy controls; and 2) To compare the lumbopelvic motion patterns and muscle activation patterns demonstrated during the tests to those demonstrated during gait to establish their functional importance in everyday activities.Dr. Bruno believes the results of this project will provide the foundation for a research program that will explore the utility of these (and other) clinical tests in diagnosing specific motor control impairments in low back pain patients. Such tests will allow clinicians to better understand the underlying mechanisms of a patient's low back pain and therefore target treatment more effectively, leading to improved patient management and a more efficient use of health care resources.
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University of Saskatchewan Prostate Research Team
Principal Investigator
Dr. Mary Buhr
Agriculture and Bioresources
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Ali El-Gayed
George Belev
Elisabeth Snead
Murray Pettitt
Jaswant Singh
Rajni Chibbar
Kishore Visvanathan
2013-2014 Health Research Group Grants - Phase II
Three year
FUNDING RECEIVED
$299,977SHRF
Description
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Building the Scholarship of Remote Presence Telementoring to Extend its Practice in Health Education and Service Delivery
Principal Investigator
Dr. Lorna Butler
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Lois Berry
Mary Ellen Andrews
Hope Bilinski
Janet McCabe
Carol Bullin
Heather Exner-Pirot
Mark Tomtene
Anna Pacik
2013-2014 Research Connections Grants
Three year
FUNDING RECEIVED
$5,000SHRF
Description
This international, invitational forum will establish a network of experts, stakeholders, and end-users on remote presence telementoring (robotics). The forum builds interdisciplinarity by bringing together stakeholders from nursing, medicine, public health, information technology, social sciences, and industry to best inform and facilitate dissemination to a broad audience. The meeting will allow those engaged in the technology to build consensus on a program of research focusing on opportunities for health education and service deliver in northern and remote communities. Hosted by the College of Nursing, on March 3-5, 2014 four countries will participate and engage with students, faculty and health professionals
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Repair of the acute injured spinal cord using transplantation of neural precursor cells and delivery of a novel drug
Principal Investigator
Dr. Josef Buttigieg
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Lois Berry
Mary Ellen Andrews
Hope Bilinski
Janet McCabe
Carol Bullin
Heather Exner-Pirot
Mark Tomtene
Anna Pacik
2013-2014 Spinal Cord Injury Research Grants
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Spinal cord injury (SCI) causes devastating impairment. Many current therapies are limited and more effective treatments are required for patients with SCI. Following the initial injury a wave of delayed cell death (apoptosis) of neurons occurs. This neuronal cell death is due to an uncontrolled increase in calcium inside the cell and this increase can spread from cell to cell in an uncontrolled manner. Dr. Buttigieg has discovered a type of protein that, under normal conditions, is key in controlling calcium levels in the cell. It's called a BK channel and has shown to protect neurons in the brain after a stroke event. Preliminary work strongly suggests that activating this protein may be neuroprotective, that is, it helps protect the spinal cord from severe injury during a crush injury. Additionally, in cases with a chronically injured spinal cord, the distribution of this BK channel impedes the function of axons and likely plays a role in limiting regeneration and remyelination. Thus in contrast to the acutely injured spinal cord, the inhibition of the BK channel protein may aid in alleviating some of the neurological impediments experienced after a SCI and may actually improve spinal cord regeneration. Dr. Buttigieg will be conducting experiments, in a clinically relevant rodent model of SCI, to provide insight that will be critical in translating this promising treatment strategy into the clinic.
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Characterizing how salmonella and E. coli use free DNA in the intestine: A source of new genes but a repressor of virulence
Principal Investigator
Dr. Andrew Cameron
Biology
Science
University of Regina
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Lois Berry
Mary Ellen Andrews
Hope Bilinski
Janet McCabe
Carol Bullin
Heather Exner-Pirot
Mark Tomtene
Anna Pacik
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
The human body is home to over a hundred trillion bacteria, the vast majority of which are beneficial to health. Why then do some bacteria, like the usually beneficial E. coli, suddenly turn bad and cause infection? In the case of nonresident bacteria like Salmonella, why do they sometimes cause infection and other times not? The answers lie in understanding how bacteria interact with the diverse environments in which they find themselves on their human host.Dr. Cameron's lab is pioneering the study of how bacteria use DNA as a source of food in the intestine, and how this process reduces infection. They have developed the unique ability to naturally induce the genes required for DNA uptake in Salmonella, allowing them to characterize the ecological role of DNA uptake as well as the genetic mechanisms that control it. Although DNA uptake can reduce virulence by satisfying food requirements, a negative outcome is that the transfer of DNA between cells can convert harmless bacteria into formidable pathogens. Thus, the lab is also characterizing and quantifying the potential for gene transfer, specifically how Salmonella and E. coli acquire antibiotic resistance and pathogenicity genes.
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Age and sex-related changes in cortical bone cellular organization across the human lifespan
Principal Investigator
Dr. David Cooper
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Christopher Thomas
Peter Pivonka
John Clement
2013-2014 RPP - Operating Grants
Two year
FUNDING RECEIVED
$67,709SHRF
$67,709CIHR
$135,418Total
Description
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Protein Structure, Function and Malfunction Conference
Principal Investigator
Dr. Miroslaw Cygler
Biochemistry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Baljit Singh
Co-Investigator(s)
Christopher Thomas
Peter Pivonka
John Clement
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$2,500SHRF
Description
The purpose of the PSFaM conference is to bring together protein scientists and structural biologists from Western Canada to present recent findings from their laboratories, to network and meet colleagues, to discuss common interests and goals, and to develop a strong, tightly knit community of protein scientists from Western Canada. Much of the presented research has been performed in part at the Canadian Light Source and the staff of the Canadian Macromolecular Crystallography Facility participates in organization of this conference. The theme of the meeting is the role of proteins in health and disease. Registration can be done through the following website: http://cmcf.lightsource.ca/psfam/. Questions can be directed to: Doreen Stumborg, (306) 966-1417, email: Doreen.stumborg@usask.ca or Mirek Cygler, email: miroslaw.cygler@usask.ca
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Supporting a greater role for patients in assessing the quality of care
Principal Investigator
Dr. Roy Dobson
Pharmacy Practice
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Rein Lepnurm
Co-Investigator(s)
Stephen Phillips
Joanne Whitty-Rogers
David Keegan
2013-2014 RPP - Operating Grants
Two year
FUNDING RECEIVED
$108,728SHRF
$108,728CIHR
$217,456Total
Description
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Connections and Communities in Health and Medicine: Manitoba-Northwest Ontario-Minnesota-Saskatchewan (MOMS) & Society for the Social History of Medicine (SSHM) Postgraduate/Early Career History of Medicine Conference
Principal Investigator
Dr. Erika Dyck
History
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Rein Lepnurm
Co-Investigator(s)
Katherine Zwicker
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$10,000SHRF
Description
This international event aims to improve our understanding of historical trends in health and medicine as they relate to current problems in local and international contexts. A second goal is to build professional connections within and between the regional MOMS and international SSHM history of medicine communities. The conference will take place September 12-14, 2013 and will be held at the University of Saskatchewan. The 37 speakers and additional 25-30 attendees consists of graduate students, faculty and health care professionals from 6 Canadian provinces, the United States (Minnesota), Europe (the UK and France), and Mexico. The event is open to the University community and public. For more information contact Katherine Zwicker at Katherine.zwicker@usask.ca or 306-966-7883.
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Deciphering the functional role of proteoglycans in the etiology of osteoarthritis
Principal Investigator
Dr. Brian Eames
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Rein Lepnurm
Co-Investigator(s)
Katherine Zwicker
2013-2014 RPP - New Investigator Salary Awards
Five year
FUNDING RECEIVED
$150,000SHRF
$150,000CIHR
$300,000Total
Description
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Kitinikewin misiwanacihisowin: Researching arts-based wellness promotion for suicide prevention among Aboriginal youth
Principal Investigator
Dr. Jo-Ann Episkenew
Indigenous Peoples' Health Research Centre
Indigenous Peoples' Health Research Centre
University of Regina
Co-Principal Investigator(s)
Dr. Rein Lepnurm
Co-Investigator(s)
Nuno Ribiero
Greg Marchildon
Linda Goulet
Charlotte Reading
Sam McKegney
Patti Ranahan
Warren Linds
2013-2014 RPP - Operating Grants
One year
FUNDING RECEIVED
$4,901SHRF
$4,901CIHR
$9,802Total
Description
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Miywâyâwin Wâhkôtawin: A Symposium to Build Relationships and Exchange Knowledge of Arts-based Innovations in Aboriginal Health Research
Principal Investigator
Dr. Jo-Ann Episkenew
Indigenous Peoples' Health Research Centre
Indigenous Peoples' Health Research Centre
University of Regina
Co-Principal Investigator(s)
Dr. Rein Lepnurm
Co-Investigator(s)
Nuno Ribiero
Linda Goulet
Warren Linds
2013-2014 Research Connections Grants
One year
FUNDING RECEIVED
$5,000SHRF
Description
From October 4-6, 2013, an invited array of 35-40 researchers, artists, and knowledge users who use arts-based methods in their work in Indigenous health will gather at the University of Regina: to share examples of innovative applications of arts in Aboriginal health research and health promotion; to foster dialogue to increase interdisciplinary collaborations; to engage in knowledge production activities that address issues in Aboriginal health; to strengthen existing relationships between researchers and knowledge users and forge new ones, conducive to successful application to competitive grant agencies; and to translate and disseminate knowledge concerning arts-based Aboriginal health research to a wide audience.
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The role of Eph receptors in the regulation of Death Receptor-induced apoptosis in T-ALL
Principal Investigator
Dr. Andrew Freywald
Experimental Pathology
Pathology and Laboratory Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Rein Lepnurm
Co-Investigator(s)
John DeCoteau
2013-2014 RPP - Operating Grants
Two year
FUNDING RECEIVED
$121,200SHRF
$121,200CIHR
$242,400Total
Description
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Multifamily psychoeducation groups to reduce expressed emotion and caregiver burden experienced by parents of adolescents who self-harm
Principal Investigator
Ms. Bethany Gelinas
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Rein Lepnurm
Co-Investigator(s)
John DeCoteau
Supervisor(s)
Dr. Kristi Wright (Lead Supervisor)
2013-2014 RPP - Doctoral Awards
Three year
FUNDING RECEIVED
$52,500CIHR
$52,500U of R
$105,000Total
Description
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The molecular mechanisms of mercury toxicity
Principal Investigator
Dr. Graham George
Geological Sciences
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Ingrid Pickering
Co-Investigator(s)
Malgorzata Korbas
2013-2014 RPP - Operating Grants
Two year
FUNDING RECEIVED
$94,376SHRF
$94,376CIHR
$188,752Total
Description
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Community and Research Alliance for Quality of Life in Older Adults (the QOL Team)
Principal Investigator
Dr. Thomas Hadjistavropoulos
Clinical Training
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Ingrid Pickering
Co-Investigator(s)
Paulette Hunter
Lilian Thorpe
Lisa Lix
Susan Whiting
Ronald Martin
David Malloy
Dennis Alfano
Sharon Kaasalainen
Vanina Dal Bello-Haas
2013-2014 Health Research Group Grants - Phase III
Three year
FUNDING RECEIVED
$717,881SHRF
Description
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Improving patient access to internet cognitive behaviour therapy for depression and anxiety: Overcoming barriers and fostering innovation
Principal Investigator
Dr. Heather Hadjistavropoulos
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Ingrid Pickering
Co-Investigator(s)
Paulette Hunter
Lilian Thorpe
Lisa Lix
Susan Whiting
Ronald Martin
David Malloy
Dennis Alfano
Sharon Kaasalainen
Vanina Dal Bello-Haas
2013-2014 Partnerships for Health System Improvement (PHSI)
Three year
FUNDING RECEIVED
$120,000SHRF
$294,118CIHR
$294,118Rx&D Health Research Foundation
$708,236Total
Description
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Global Health Conference: Merging Minds on Global Health: a multidisciplinary call to action
Principal Investigator
Dr. Lori Hanson
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Ingrid Pickering
Co-Investigator(s)
Louise Buhler
2013-2014 Research Connections Grants
Three year
FUNDING RECEIVED
$6,500SHRF
Description
A Global Health Conference "Merging Minds for Global Health: A multidisciplinary call to action", will be held September 20, 21, 2013 in the Health Sciences Building, University of Saskatchewan. The conference objectives are to: 1) analyze/disseminate knowledge on a wide range of global health issues; 2) explore ways to address these issues through collaborative research and action; 3) showcase current research and development projects and promote intensification of multidisciplinary global health initiatives at the U of S. The conference anticipates 300-350 participants, mostly U of S researchers, faculty, students and some community members engaged in global health work. A conference website www.saskglobalhealth2013.usask.ca provides registration information.
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Nesfatin-1 regulation of reproduction
Principal Investigator
Dr. Azadeh Hatef
Veterinary Biomedical Sciences
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Ingrid Pickering
Co-Investigator(s)
Louise Buhler
Supervisor(s)
Dr. Suraj Unniappan (Lead Supervisor)
2013-2014 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Reproduction requires energy. Therefore energy intake, metabolism and reproduction are very closely linked. Several hormones are involved in the regulation of metabolism and reproduction, and defects in the production of some hormones and/or there actions can result in reproductive and metabolic dysfunctions. Recent research has found nesfation-1 to be a novel hormone that regulates various aspects of metabolism and some pituitary hormones that regulate reproduction. The understanding of nesfatin-1's role on reproduction, however, is in its infancy. Dr. Hatef's research aims to explain the role of nesfatin-1 in regulating reproductive functions. Dr. Hatef's research has three aims: 1) study nesfatin-1 in the brain, pituitary, and gonads (testis and ovary) of normal, diabetic and obese mice; 2) test the effects of nesfatin-1 in regulating hormone synthesis and secretion in those brain, pituitary and gonads of mice, and; 3) compare results against mice that lacks nesfatin-1 (due to deletion of the gene encoding nesfatin-1). The outcomes of the research will provide significant new information on the role of nesfatin-1 in diabetes and obesity.
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Exploring polic officers' susceptibility to posttraumatic stress after exposure to fictional and real-world trauma
Principal Investigator
Ms. Samantha Horswill
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Ingrid Pickering
Co-Investigator(s)
Louise Buhler
Supervisor(s)
Dr. Nicholas Carleton (Lead Supervisor)
2013-2014 RPP - Doctoral Awards
Three year
FUNDING RECEIVED
$52,500CIHR
$52,500U of R
$105,000Total
Description
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Saskatchewan Population Health and Evaluation Research Unit (SPHERU)
Principal Investigator
Dr. Bonnie Jeffery
Saskatchewan Population Health and Evaluation Research Unit (SPHERU)
Social Work
University of Regina
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Sarah Oosman
Diane Martz
Paul Hackett
Sylvia Abonyi
Nuelle Novik
Shanthi Johnson
Tom McIntosh
2013-2014 Health Research Group Grants - Phase III
Three year
FUNDING RECEIVED
$749,335SHRF
Description
Since 1999 SPHERU has established itself as a leader in population health research through its mission to promote health equity by addressing population health disparities through policy-relevant research. Building on SPHERU's knowledge and expertise, this program of research focuses on improving rural and northern Aboriginal and non-Aboriginal seniors' equity in health outcomes and service access. This research program, called Healthy Aging in Place: Improving Rural and Northern Aboriginal Seniors' Health through Policy and Community Level Interventions, addresses the health issue of the growing disparities in health outcomes for rural non-Aboriginal and northern Aboriginal seniors through population health intervention research.The research program includes several interrelated projects: 1) improving rural seniors' mobility and social interaction through intervention research; 2) supporting health aging through walkable built environments; 3) addressing rural seniors' access to information; 4) Wuskiwiy-tan! (Let's move!) aging well in a northern Saskatchewan Metis community; and 5) an examination of the factors that contribute to emotional wellbeing and mental health care for seniors in rural Saskatchewan.These research projects collectively address the diversity of supports needed for seniors in rural and northern communities and aim to identify, develop and assess interventions to support healthy aging in place. The research will take place in several rural and northern Saskatchewan communities in four health regions through collaboration with community partners and policy makers. The understanding gained through this research will enhance the healthy again experience of seniors in rural and northern communities in Saskatchewan.
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Systematic mapping of the mitochondrial protein interaction network
Principal Investigator
Dr. Matthew Jessulat
Chemistry and Biochemistry
Science
University of Regina
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Sarah Oosman
Diane Martz
Paul Hackett
Sylvia Abonyi
Nuelle Novik
Shanthi Johnson
Tom McIntosh
Supervisor(s)
Dr. Mohan Babu (Lead Supervisor)
2013-2014 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
The mitochondria is an essential cellular component containing approximately 1,200 proteins which, due to technical limitations, is poorly understood compared to other cell components. Mutations to some of these proteins have recently been linked to medical conditions such as heart disease, cancer, Parkinson's, Alzheimer's, Huntington's, and other neurodegenerative and neuromuscular disorders, leading to speculation that mitochondrial dysfunction may be linked to the onset of progression of these diseases and the prospect of targeting the mitochondria for pharmaceutical intervention.Dr. Jessulat proposes to map the protein-protein interaction networks (interactome) of this organelle using an optimized system of mitochondrial enrichment, purification, protein affinity purification, and mass spectrometry, in the model yeast Saccharomyces cerevisiae. By using non-fermentative media, mitochondria are enriched, allowing greater recovery of mitochondrial proteins even in reduced overall cell volumes. The interacting proteins can be compared and identified using mass spectrometry, and interactions can be confirmed by reciprocally tagging and recovering the bait and prey proteins in the reverse configuration. Because proteins which physically interact often have functional relationships, this will generate a foundation for understanding protein functions within the mitochondria. By merging this interaction dataset with recent genetic interaction datasets, we expect to uncover novel insights relating to normal mitochondrial systems biology, to be used to identify the aberrations that may lead to human diseases.
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A combinatorial immunotherapy of trastuzumab and HER-2/P30-expressing adenoviral vector vaccine for HER-2/neu-positive breast cancer
Principal Investigator
Dr. Kalpana Kalyanasundaram Bhanumathy
Oncology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Sarah Oosman
Diane Martz
Paul Hackett
Sylvia Abonyi
Nuelle Novik
Shanthi Johnson
Tom McIntosh
Supervisor(s)
Dr. Jim Xiang (Lead Supervisor)
2013-2014 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$50,000SHRF
$50,000Terry Fox Research Institute
$100,000Total
Description
2013-14 Terry Fox Postdoctoral Fellow, co-funded by the Terry Fox Research InstituteHER-2/neu (HER-2) is a human breast cancer antigen. Dr. Kalpana and her team has previously demonstrated that certain antigens stimulate cytotoxic T lymphocyte (CTL) responses that lead to a synergistic effect during therapy on well-established breast cancers in transgenic mice and the induction of long-term anti-tumour immunity. The objectives of Dr. Kalpana's research are to construct an expressing HER-2 antigen containing P30-epitope and to assess the results of a combinatorial therapy mice carrying human immune system.The study is related to the development of a combinatorial immunotherapy for breast cancer, and thus fits the priority areas of senior diseases.
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Synchrotron-based imaging to analyse cerebral calcium and biochemical markers of oxidative stress in a mouse photothrombotic stroke model
Principal Investigator
Dr. Michael Kelly
Division of Neurosurgery
Surgery
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Sarah Oosman
Diane Martz
Paul Hackett
Sylvia Abonyi
Nuelle Novik
Shanthi Johnson
Tom McIntosh
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Each year, 50,000 Canadians of all ages suffer a stroke and 14,000 die as a result, making stroke the number three killer in Canada. Stoke is also the leading cause of long-term disability, with 330,000 people in Canada living with its effects. The development of innovative therapies, which are necessary to reduce the tremendous burden that stroke has on society will come through a better understanding of the chemistry and cellular mechanisms of stroke. When a patient has a stroke some of the involved brain does not immediately die. This so-called "penumbra region" potentially can be salvaged by preventing swelling and inflammation after stroke by instituting an effective treatment. Such treatments are no yet available and one of the goals of understanding how the brain responds to stroke is to identify therapeutic targets.Synchrotron imaging enables us to understand stroke better at the elemental and chemical levels and test how new therapies affect this chemistry. In his research Dr. Kelly will use synchrotron, X-rays, and ultraviolet light to image an array of elements (like calcium and iron) as well as chemical groups (like proteins, lipids, etc.). The study will use a minimally invasive mouse model of cerebral stroke for these experiments. Dr. Kelly, with his unique synchrotron training and cerebrovascular neurosurgery expertise is uniquely positioned to conduct research in the synchrotron priority area and translate his findings into clinical trails to address cardiovascular health.
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Regulation of programmed cell death in monocytic cells via autophagy and its impact on HIV pathogenesis
Principal Investigator
Dr. Marko Kryworuchko
Public Health
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Sarah Oosman
Diane Martz
Paul Hackett
Sylvia Abonyi
Nuelle Novik
Shanthi Johnson
Tom McIntosh
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$119,967SHRF
Description
Over 30 million people worldwide live with HIV infection, the cause of AIDS, and there is still no cure. In contrast to the national average, rates of HIV infection in Saskatchewan have increased over the last decade, unfortunately as a result of increasing numbers of people infected within our Aboriginal communities.Despite the success of anti-viral medications, the virus is still able to infect and hide in immune cells such as lymphocytes, monocytes/macrophages, and other cells, forming reservoirs of HIV. Normally monocytes/macrophages are responsible for the destruction and clearing out of invading microorganisms including HIV, by engulfing the pathogen and degrading it in a complex system of intracellular vacuoles referred to as autophagy.However, such functions eventually become impaired in HIV patients and these cells exhibit altered susceptibility to programmed cell death, a mechanism by which the immune system is normally able to balance and regulate itself. Recent research has found that monocyte cell death is closely linked to this very same process of autophagy. Therefore, in order to better understand this, Dr. Kryworuchko will use modern molecular biology approaches to determine the mechanisms by which monocyte autophagy and cell death are altered during the course of HIV infection and how it may be possible to control this process. The research findings that result may have implications on why monocyte/macrophage function is impaired during HIV infection, how viral reservoirs are formed and maintained, and will lay the foundation for future studies aimed at eradicating HIV reservoirs from the body.
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The making sure research study: Life support planning with the web-based decision guide (WeDecide)
Principal Investigator
Dr. Jennifer Kryworuchko
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
John Reid
Donna Goodridge
Steven Lewis
Karen Levesque
Petrina McGrath
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$115,931SHRF
Description
Patient and family involvement during healthcare decisions during serious illness is an important component for success. Researchers have shown when the health decision-making process does not engage patients and their families, the care provided does not match patient preferences or meet their needs. Tools called patient decision aids are already used in many health care settings to help patients and families understand their options and figure out the benefits and harms of a treatment to decide what is right for them. Dr. Kryworuchko's team wants to know if a new web-based decision aid can improve conversations between healthcare teams and hospitalized, seriously ill, older adult patients and their families when they are facing decisions about using technology to keep a person alive if they become seriously ill. The object is not to convince anyone to choose in a particular way, but to help healthcare teams have healthy conversations with patients and families so their needs are met and that they get the care they want and no more. This study will add to what is already known about overcoming the challenge of keeping patients and families at the center of their healthcare decisions.
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Combating psychiatric diseases: Using DISC1 to identify novel therapeutic treatments for mental disorders
Principal Investigator
Dr. Adelaine Leung
Veterinary Biomedical Sciences
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
John Reid
Donna Goodridge
Steven Lewis
Karen Levesque
Petrina McGrath
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$60,000SHRF
$10,000Schizophrenia Society of Saskatchewan
$50,000Schizophrenia Research Foundation of Saskatchewan
$120,000Total
Description
SHRF Establishment Grant co-funded by Schizophrenia Society of Saskatchewan and Schizophrenia Research Foundation of Saskatchewan
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Between Chinese traditional medicine and western medicine: A negotiated medical decision making process among mainland Chinese immigrants in Saskatchewan
Principal Investigator
Dr. Yixi Lu
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
John Reid
Donna Goodridge
Steven Lewis
Karen Levesque
Petrina McGrath
Supervisor(s)
Dr. Louise Racine (Lead Supervisor)
2013-2014 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Chinese immigrants have become the largest foreign-born visible minority in Canada. In Saskatchewan, the Chinese population from mainland China has increased significantly. Thus, it is important for Saskatchewan healthcare providers to be informed about these immigrants' unique healthcare experiences and practices. Chinese immigrants' health experiences include the use of Chinese traditional medicine. In addition, social and cultural barriers heavily influence their communication with their physicians. Although these issues have been studied before, how the choice of Chinese traditional medicine and/or western medicine interacts with their illness management and communication with healthcare providers has not been explored. This research study aims to develop a theoretical framework to explain the decision-making processes mainland Chinese immigrants use to select traditional and/or western medicine therapies for illness management. Through in-depth interviews, the study will seek to develop a model about the negotiated decision-making process among Chinese patients, Chinese traditional medicine practitioners and western medicine practitioners, and its impact on the patients' perceived health outcomes. The study will contribute knowledge to a discussion of the negotiation of the professional boundaries between western medicine and traditional Chinese medicine, and sensitize western health providers to traditional medicine and related alternative healing practices. The findings will have implications in the management of chronic diseases and cancer among a minority cultural group, and will help health care professionals design relevant health promotion programs and culturally responsive care.
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A telemetered device to assess continence function and predict therapeutic outcomes in women with urinary incontinence
Principal Investigator
Dr. Stephanie Madill
Physical Therapy
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Tom Mainprize
Gordon Sarty
Roger Pierson
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$90,130SHRF
Description
Urinary incontinence affects 30-60 per cent of women. It frequently occurs in female athletes, pregnant and postpartum women, women who are obese, and older women. It results from stretching injuries to the pelvic floor. Women with incontinence often experience high rates of anxiety and depression. There are also high financial costs, both for affected women and our health care system. Pelvic floor muscle exercise is an effective treatment for incontinence; however, current diagnostic methods are unable to predict who will most benefit from exercise therapy versus surgery.The purpose of this research is to improve treatment outcomes for women with incontinence through developing and testing a novel instrument. This will be achieved in three steps. First, we will design a new device to measure pelvic floor function during activity. Second, we will measure the differences in pelvic floor function between 20 women with incontinence and 20 without during various activities. Third, we will determine which measures of pelvic floor function are predictive of improvement following 12 weeks of pelvic floor exercise training in 40 women with incontinence.This research will make an important contribution to the measurement and treatment of incontinence and will support the initiatives of the Saskatchewan Pelvic Floor Pathway. It will allow health professionals to better predict who will benefit from exercise therapy, leading to earlier, and more appropriate treatment as well as cost savings for the health care system. Most importantly, it will benefit the mental and physical health of women affected by this often embarrassing and challenging condition.
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Conformation specific targeting of misfolded superoxide dismutase 1 as an immunotherapeutic strategy for Amyotrophic Lateral Sclerosis
Principal Investigator
Ms. Kristen Marciniuk
Vaccine and Infectious Disease Organization
Biochemistry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Tom Mainprize
Gordon Sarty
Roger Pierson
Supervisor(s)
Dr. Scott Napper (Lead Supervisor)
2013-2014 RPP - Doctoral Awards
Three year
FUNDING RECEIVED
$52,500CIHR
$52,500U of S
$105,000Total
Description
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Symposium: "Advancing epidemiology in Saskatchewan: Where to from here?"
Principal Investigator
Ms. Christine McDougall
Saskatchewan Cancer Agency
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Joshua Marko
2013-2014 Research Connections Grants
Three year
FUNDING RECEIVED
$3,750SHRF
Description
The purpose of the Saskatchewan Epidemiology Association's Annual Symposium and workshop is to advance the understanding and application of epidemiology through continuing education and network enhancement. This year's symposium titled: “Advancing epidemiology in Saskatchewan: Where to from here?” will be held on November 7th and the workshop: “Health Equity Surveillance in Saskatchewan: Moving an Agenda Forward” will be held on November 8th at the Travelodge Hotel and Conference Centre in Regina. Over 120 participants are expected to attend this event in person with an additional 50 participants online. Participants will include health professionals, researchers, and students from various fields. The SEA symposium 2013 planning co-chair Ms. Christine McDougall can be contacted to address questions about the event. Registration and event information is also hosted on the Saskatchewan Epidemiology Association website at: http://www.saskepi.ca/News/Conference.htmlRegistration for the symposium and/or workshop can be done at http://www.picatic.com/SEA2013CONFERENCE
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Antidepressants as placebo and panacea: Implications for evidence-based practice
Principal Investigator
Dr. Linda McMullen
Psychology
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Joshua Marko
2013-2014 RPP - Operating Grants
Two year
FUNDING RECEIVED
$27,165SHRF
$27,165CIHR
$54,330Total
Description
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Establishment of a porcine model to study human genital gonorrhoea and chlamydia
Principal Investigator
Dr. Francois Meurens
Vaccine and Infectious Disease Organization
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Rajinder Parti
Jo-Anne Dillon
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Dr. Meurens' research project aims to establish pigs as a new viable model to mimic human gonorrhea and chlamydia co-infections. During symptomatic infection, Neisseria gonorrhoeae and Chlamydia trachomatis both elicit pro-inflammatory responses characterized by strong recruitment of neutrophils. Infections that go into the upper genital tract of women can lead to pelvic inflammatory disease and subsequent fertility problems and infections with both bacteria has also been shown to increase the risk for HIV infection. Currently, the rates for both diseases are especially high in Aboriginal communities.In Canada, several strains of N. gonorrhoeae resistant to all antibiotics have been identified. No vaccine has been developed against either gonorrhea or chlamydia. The development of vaccines has been complicated by the absence of meaningful animal models in which to better mimic human infections. Indeed, there are still no optimal models to reproduce human gonorrhea and the porcine model of human chlamydia has only been used in Europe so far. For the study of many human infectious diseases, pigs have been demonstrated as extremely valuable. They share with humans many anatomical and physiological particularities and respond similarly to various infectious agents. Using a combination of cell and tissue cultures and in vivo approaches (directly in live pigs), Dr. Meurens research will establish the chlamydia model in pigs and test the possibility of developing a co-infection model with N. gonorrhoeae. The model will allow for further insight into the pathogenesis of the diseases and will enable development and testing of new treatments and vaccine candidates.
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Assessing interictal cognitive effects and cortical excitability in migraine and epilepsy
Principal Investigator
Dr. Marla Mickleborough
Medical Imaging
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Rajinder Parti
Jo-Anne Dillon
Supervisor(s)
Dr. Paul Babyn (Lead Supervisor)
2013-2014 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Migraine and epilepsy are both neurological disorders characterized by frequent attacks of headache or seizure, respectively. While the exact relationship between migraine and epilepsy is still unclear, recent scientific advances suggest that hyperexcitable brain activity may be a shared mechanism underlying these disorders. Dr. Mickleborough's research will use functional magnetic resonance imaging to look at cortical excitability in attention and reading processes in migraine and epilepsy patient groups between attacks -the interictal period. Brain activity will be compared in these two disorders to known networks of attention and reading. This will be the first study to use neuroimaging to compare interictal hyperexcitability and cognitive functioning in migraine and epilepsy patients. While patient well-being between attacks is reported as important to their overall quality of life, this period is understudied, especially in epilepsy. By studying this interictal period, we are gaining knowledge about an area of importance to patients, assessing shared pathophysiology between migraine and epilepsy patients, as well as potentially identifying hyperexcitable cortical response as an early indicator predicting migraine and epilepsy.
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SPOR Network in Primary and Integrated Health Care Innovations: Saskatchewan LOI
Principal Investigator
Dr. Nazeem Muhajarine
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Rajinder Parti
Jo-Anne Dillon
2013-2014 SPOR Network in Primary and Integrated Health Care Innovations
One year
FUNDING RECEIVED
$25,000SHRF
$73,750CIHR
$98,750Total
Description
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Nesfatin-1 integration of stress and metabolism
Principal Investigator
Dr. Edward Narayan
Veterinary Biomedical Sciences
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Rajinder Parti
Jo-Anne Dillon
Supervisor(s)
Dr. Suraj Unniappan (Lead Supervisor)
2013-2014 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Stress is a complex response mediated by many hormonal factors. Metabolic regulation is also achieved by the actions of a large number of hormones. One of the recent additions to a growing list of metabolic endocrine factors is nesfatin-1, an eighty-two amino acid protein. Nesfatin-1 suppresses food intake and increases weight loss. It has also been shown that nesfatin-1 enhances insulin secretion from the pancreas. The appetite suppression effect of nesfatin-1 was reduced in the presence of an antagonist of corticotropin releasing factor, a brain hormone that is critical in stress mediation. Dr. Narayan's research found an abundance of nesfatin-1 and its receptor in the brain, pituitary and adrenal glands, tissues that produce hormones that mediate the stress response. However, the role of nesfatin-1 in mediating a number of these stress responsive hormones is not yet known. Dr. Narayan's research project will identify the role of nesfatin-1 on the stress mediating tissues. The research aims to determine the syntheses and secretion of stress hormones from the brain, pituitary and adrenal glands of mice treated with nesfatin-1. In addition, the levels of stress hormones in mice lacking nesfatin-1 will be determined. Finally, normal and nesfatin-1 knockout mice will be fed a high fat diet to induce obesity and type 2 diabetes and the stress hormone profile in these obese mice will be determined. The overall effort of this research will help to understand the role played by nesfatin-1 on the stress axis. Our results are expected to provide significant new information on stress response mediation in obesity and diabetes.
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Transcriptional control of myelin gene expression and myelination by oligodendrocytes in young adult and aged mice
Principal Investigator
Dr. Adil Nazarali
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Rajinder Parti
Jo-Anne Dillon
2013-2014 RPP - Operating Grants
Two year
FUNDING RECEIVED
$93,778SHRF
$93,778CIHR
$187,556Total
Description
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Developing a health equity agenda: From a shared vision to policy and practice
Principal Investigator
Dr. Cory Neudorf
Public Health Office
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Jennifer Cushon
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$10,000SHRF
Description
The University of Saskatchewan, National Collaborating Centre for the Determinants of Health, and the Canadian Council of the Social Determinants of Health are leading a health equity summit funded through CIHR's Knowledge Translation Supplement Grant. The purpose of the day will be to share best practices in health equity from leading experts and for attendees to participate in facilitated discussions in order to inform a national health equity agenda. There will be 100 attendees by invite only.
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Exploring Health at the Speed of Light
Principal Investigator
Dr. Helen Nichol
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Ingrid Pickering
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$1,000SHRF
Description
There is tremendous local interest in the synchrotron and what it can do. This event aims to inform and inspire the public by showing how medical implants and diseases that affect them can be studied at our synchrotron. Also THRUST fellows want to learn to explain in simple terms what they are doing to non-scientists. On June 6th during the day, selected THRUST trainees will speak with science students at Oskayak High School. In the evening, THRUST trainees will share refreshments and have casual one-on-one discussions about their research with the general public in the Oskayak gymnasium.
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Gene Expression Mapping using Synchrotron Light
Principal Investigator
Dr. Helen Nichol
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Nazeem Muhajarine
Co-Investigator(s)
Ivar Mendez
Bogdan Popescu
Michael Kelly
Dean Chapman
Graham George
Ingrid Pickering
Valerie Verge
2013-2014 Health Research Group Grants - Phase III
One year
FUNDING RECEIVED
$250,000SHRF
Description
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Walking balance control and falls in the community after incomplete spinal cord injury
Principal Investigator
Dr. Alison Oates
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Stephan Milosavljevic
Joel Lanovaz
Gary Linassi
Catherine Arnold
2013-2014 Spinal Cord Injury Research Grants
Two year
FUNDING RECEIVED
$146,412SHRF
Description
Relearning to walk is a top priority for individuals with an incomplete spinal cord injury (iSCI). Many do walk again, however, about 75 per cent of these individuals will experience a fall while walking. Walking training after iSCI has focused mostly on taking steps, yet balance is equally important for walking. Very little is known about walking balance in people with iSCI. The overall goal of our research is to understand the walking balance deficits of people with iSCI, including how these deficits contribute to falls.This research project will: 1) study differences in walking balance between approximately 50 individuals with iSCI and an equal number of healthy adults; 2) identify the most effective clinical measures to test walking balance in iSCI; and 3) predict which individuals with iSCI are at greatest risk of falling. Using state-of-the-art equipment and clinical tests for measuring movement and muscle activity, the research team will assess participants' walking, balance and strength. The team will also follow the participants with iSCI for one year to document their falls. This research is the first of its kind. It will develop an understanding of why individuals with iSCI fall, and learn more about how falls and injuries can be prevented. It will also lead to a greater quality of life and improved health for people with iSCI, as well as a decrease in long-term health care costs. The findings should stimulate more research on the training of walking balance after iSCI, which has received little attention to date, but is vital for safe walking.
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Addressing and Redressing Issues of Respiratory Health and Housing Among First Nations People: Program & Policy Options
Principal Investigator
Dr. Punam Pahwa
Canadian Centre for Health and Safety in Agriculture (CCHSA)
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Colum Smith
Niels Koehncke
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$5,000SHRF
Description
The symposium will be held Wednesday, November 20, 2013 at the Hilton Garden Inn, Saskatoon. It will highlight knowledge about the linkages between adult and child respiratory health outcomes and housing environments in First Nations communities, focusing on program and policy intervention possibilities. The objective is to learn about interventions currently taking place in Canadian First Nation communities, and stimulate discussion on successes, strengths, challenges and opportunities. Attendees will include invited speakers and multiple stakeholders (e.g. First Nations community members, FINIH, INAC, FSIN, and NITHA), community partners in current research, and active members of the research community from across Canada.
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Research Matters: Facilitating Research Connections
Principal Investigator
Dr. Elan Paluck
Research and Performance Support
Research and Health Information Services
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Cara Spence Gress
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$3,000SHRF
Description
The RQHR Research Department is creating a unique opportunity to facilitate the development and growth of our clinical research teams in Saskatchewan. The first of a series of facilitated events is planned on the evening of June 19th in Regina, targeted specifically at RQHR physicians. The goal of this event is to bring together leaders, representing diverse areas of clinical research currently conducted within the RQHR. The objective of this event is to create connections among these clinician scientists in the effort to identify strategic research priorities, and to develop feasible research teams. Fifty physicians have already pledged their commitment to attend this event, representing a broad spectrum of expertise including: cardiology, infectious disease, orthopedic surgery, oncology, renal, primary care, medical imaging, obstetrics and gynecology, among others. With the use of the respected Dr. Brian Goldman as a catalyst, we anticipate this event will foster recognition of collaborative research teams, and the intrinsic relationship between producing clinically based evidence and improved patient outcomes. This event is by invitation only.
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Assessing the analgesic effects of nicotine on pain threshold and tolerance in humans: An exploratory investigation
Principal Investigator
Mrs. Hollyanne Parkerson
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Cara Spence Gress
Supervisor(s)
Dr. Gordon Asmundson (Lead Supervisor)
2013-2014 RPP - Doctoral Awards
Three year
FUNDING RECEIVED
$52,500CIHR
$52,500U of R
$105,000Total
Description
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Healthy health care workforces: Testing a model of work engagement and burnout among palliative care nurses in rural and urban practice settings
Principal Investigator
Dr. Kelly Penz
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Laurie-ann Hellsten-Bzovey
Donna Goodridge
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$119,859SHRF
Description
Understanding the nursing workforce in palliative and end of life care is a crucial aspect of human resource planning, especially in light of the changing rural and remote health care system. The goal of this two-part sequential, explanatory mixed methods study is to better understand the practice and professional quality of life of nurses who provide palliative and end of life care in rural and urban Saskatchewan. Phase 1 will involve the final development, piloting testing, and provincial implementation of a cross-sectional survey of approximately 2 -3,000 eligible rural and urban nurses who provide palliative and end of life care in community, hospital, and long-term care settings. Phase 2 will employ interpretive description methodology to explore palliative and end of life nursing care in the context of Saskatchewan health care environments. Although larger acute care settings have numerous palliative care resources available to nurses, the emotional impact of striving to provide the best possible care in very stressful and complex situations remains very real. The results of this project will be used to identify areas of concern in both rural and urban settings and will provide a foundation for a program of research designed to improve the professional quality of life of those who practice in the area of palliative and end of life care.
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Custody and Caring: 13th Biennial International Conference on the Nurse's role in the Criminal Justice System
Principal Investigator
Ms. Cindy Peternelj-Taylor
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Arlene Kent-Wilkinson
2013-2014 Research Connections Grants
Three year
FUNDING RECEIVED
$10,000SHRF
Description
The goal of the conference is to highlight innovations in practice, education, research, administration, and policy development in the field of correctional health and forensic mental health in Canada and abroad. Clinical issues and work life issues that are unique to nurses and other health care professionals working within these systems will be featured. The conference will be held October 2-4, 2013 at the Delta Bessborough Hotel in Saskatoon, SK. Registration is available online at http://www.usask.ca/nursing/custodycaring/registration.php
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CIHR-THRUST 4th Annual Retreat
Principal Investigator
Dr. Ingrid Pickering
Geological Sciences
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Arlene Kent-Wilkinson
2013-2014 Research Connections Grants
Three year
FUNDING RECEIVED
$3,000SHRF
Description
CIHR- THRUST is the synchrotron health training program at the University of Saskatchewan. It brings together a diverse group of fellows (trainees) and their mentors, from clinical and biomedical researchers to physicists, engineers and Canadian Light Source research personnel. This day-long meeting in early November is a highlight of our year, convening around 100 fellows, mentors and key invited participants for presentations from internal and international speakers, poster presentations by all fellows, and the opportunity for health research networking, brainstorming and stimulation of ideas within our diverse group.
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The implementation and evaluation of clinical pathways in Saskatchewan
Principal Investigator
Dr. Thomas Rotter
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Ilze Duncan
Leigh Kinsman
Shannon Scott
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Clinical pathways have the potential to promote best care practices, patient safety, and efficiency in the health system by creating shared understanding of how services integrate across system boundaries. To reduce wait times and streamline diagnostic and therapeutic services in several critical areas, Saskatchewan has developed and piloted five pathways with plans for more in the future. However, before a comprehensive and rigourous evaluation of these initiatives can be undertaken, there are important gaps to fill in terms of the evidence base for effective pathway development and implementation.The proposed study aims to address these gaps and investigate why and under which circumstances a pathway could lead to improved care. This research project also proposes to translate findings to the provincial context to improve current and future pathway implementation and evaluation. The first phase of the research will be to review the international literature on successful implementation strategies and the effects of pathways in hospitals and primary care. Follow-up interviews with key primary authors will help elaborate the factors associated with successful pathway implementation. From this knowledge synthesis phase, Dr. Rotter will develop a framework for clinical pathway implementation and evaluation. He will also establish a Saskatchewan Expert Group on pathways, which will facilitate knowledge translation -making recommendations for which health conditions would benefit from pathways and which implementation strategy should be used. Outcomes from this project are expected lead to more consistent and evidence-based pathway uptake resulting in quality improvement of Saskatchewan's health care services.
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Defining epidemiological and clinical relevance of gardnerella vaginalis subgroups in bacterial vaginosis using culture-based and next-generation molecular techniques, building on a unique and growing culture collection from African and Canadian women
Principal Investigator
Dr. John Schellenberg
Veterinary Microbiology
Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Ilze Duncan
Leigh Kinsman
Shannon Scott
Supervisor(s)
Dr. Janet Hill (Lead Supervisor)
2013-2014 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
The overall purpose of the proposed research is to define clinical relevance of specific subgroups of Gardnerella vaginalis in relation to bacterial vaginosis (BV), a common but poorly understood vaginal condition associated with increased risk for HIV infection and pre-term birth. Since G. vaginalis is also found in healthy women without vaginal symptoms, further work is required to define subgroups in terms of disease-causing characteristics. Our previous work has defined four subgroups of G. vaginalis that may potentially be new Gardnerella species. One subgroup ("B") has been found to be associated with BV diagnosis and many strains of this subgroup require oxygen-free conditions to grow suggesting that they may have been overlooked in previous studies. Dr. Schellenberg proposes to determine whether women with BV vaginal symptoms or disease recurrence are more likely to be colonized with G. vaginalis subgroup B by screening vaginal samples using subgroup-specific probes. By culturing G. vaginalis isolates from these samples in oxygen-free conditions, he will characterize potential pathogenic factors such as biofilm formation on cultured vaginal cells, growth on vaginal mucus, and production of the enzyme sialidase in comparison with other subgroups. By analysis and annotation of genomes from group B organisms, the research will then define genetic profile and expression of possible disease-causing factors using next-generation molecular techniques. This research will help explain the microbiological basis for an extremely common vaginal condition with high but poorly defined significance for reproductive health, potentially leading to improved detection, diagnosis and treatment of BV.
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"Biomarker Development" Workshop & Dinner
Principal Investigator
Dr. Baljit Singh
Western College of Veterinary Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Paul Babyn
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$3,000SHRF
Description
An all-day Biomarker Development Workshop will be held at Marquis Hall, University of Saskatchewan on April 10, 2014. This event is open to all to attend. The purpose of this workshop is to promote the sharing of knowledge of newly developed technologies in the area of biomarker development with a specific focus on nuclear biomarkers, nanoprobes and infectious diseases and to use a group consensus method to write up a Biomarker Development Recommendations Report. The audience is expected to be comprised primarily of University of Saskatchewan faculty, technicians, residents, graduate and undergraduate students. To register please contact Karen Mosier at karen.mosier@usask.ca.
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2020 Health Visions Conference Series: Health Care Innovation
Principal Investigator
Mr. Sanj Singh
Greater Saskatoon Chamber of Commerce
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
Glen Schuler
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$5,000SHRF
Description
The P4 (preventative, predictive, participatory and personalized) model of health care serves as the context within where researchers, clinicians, service providers and the business community can gather to discuss about innovation and transformation in the healthcare system. The focus is to look at how research, innovation and commerce can work together to translate knowledge into products and services which can enhance the quality of health care while bending the cost curve. The event aims to attract 250 attendees. On November 5th and 6th, 2013, the conference will be held at the Western Development Museum which houses some Saskatchewan's historic innovations in health. This event is by registration and is open to academics, clinicians, business and government.
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Research Showcase 2013. Research Matters
Principal Investigator
Ms. Cara Spence Gress
Research and Health Information Services
Research and Health Information Services
Regina Qu'Appelle Health Region
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
June Zimmer
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$5,000SHRF
Description
Research Showcase is an annual research sharing and networking event, hosted by the Research Department of the Regina Qu'Appelle Health Region (RQHR). Every year, this much anticipated event draws together a diverse gathering of participants, including: health and science researchers, policy makers, clinicians, physicians, students, and the general public in order to highlight research conducted within the region over the past year. The relevancy of the event and engaging discussions surrounding the applications of research into practice and policy draws an increasing number of participants every year. Participation is open to the public. Website: http://www.rqhr-rps.ca/Event email: research.showcase@rqhealth.ca
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FASD at the Frontline: Dialogue and Strategies for New Outcomes
Principal Investigator
Dr. Michelle Stewart
Justice Studies
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Kristin Musselman
Co-Investigator(s)
June Zimmer
2013-2014 Research Connections Grants
Two year
FUNDING RECEIVED
$3,000SHRF
Description
Although FASD is a health issue, individuals with FASD are involved with the courts and social services. This workshop brings together frontline and policymakers from health, justice and social services to discuss barriers to delivering effective services, the ongoing concern of over-representation in the justice system, and new approaches to working with clients. The workshop will facilitate knowledge transfer by examining practices inside and outside the province. The goal is to foster new ideas and strategies. A final report will be made available for distribution. There will be online registration for the event held April 23 at the University of Regina.
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Saskatchewan Epilepsy Research Initiative
Principal Investigator
Dr. Jose Tellez-Zenteno
Division of Neurology
Neurology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Farzad Moien-Afshari
Co-Investigator(s)
Lisa Kalynchuk (Co-Principal Applicant) Ron Borowsky
Changiz Taghibiglou
Francisco Cayabyab
2013-2014 Health Research Group Grants - Phase I
Two year
FUNDING RECEIVED
$30,000SHRF
Description
The Saskatchewan Epilepsy Research Team (SERT) is comprised of researchers from diverse academic disciplines with a common mission of developing a clinical and basic sciences group to serve patients with intractable epilepsy in Saskatchewan. SERT has identified seven objectives: 1) to undertake an interdisciplinary clinical and basic research program for epilepsy; 2) to build an epilepsy brain bank to foster collaboration between clinical and basic researchers at the University of Saskatchewan; 3) to employ advanced imaging techniques, such as fMRI and PET-CT, to study and treat patients with intractable epilepsy; 4) to instigate major epidemiological projects focused on patients with epilepsy; 5) to develop new services linked with clinical research such as an epilepsy transition clinic; 6) to submit two to three national lever grant applications; and 7) to build research capacity in the epilepsy field in the province of Saskatchewan, including senior and junior faculty, graduate, and summer students.
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Role stressors and coping strategies of nurse managers in acute care facilities in Saskatchewan and Alberta
Principal Investigator
Dr. Sonia Udod
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Farzad Moien-Afshari
Co-Investigator(s)
Greta Cummings
W. Dean Care
2013-2014 Establishment Grants
Three year
FUNDING RECEIVED
$119,433SHRF
Description
The complex healthcare environment and need for work-life balance requires unique approaches to create and maintain healthy work environments for nurse managers and their staff. The purpose of this project is to examine nurse manager stressors and coping strategies in acute care facilities to help create healthy work environments for managers. Investigating nurse managers' stress and how they cope will help develop a better understand of managers' mental and physical health. A manager's health affects managerial performance and also influences their willingness to stay in their position. Understanding the stress that a nurse manager in under is very important for designing support systems that lead to positive staff experiences in the workplace, and for positive patient outcomes - both of which are high priorities for Saskatchewan's health care system. The study builds on existing literature suggesting managers face high stress and conflicting role demands, making their positions really difficult. This study aims to improve the overall satisfaction of nurse managers and increase retention by sharing successful coping strategies.
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Quality in Medical Imaging (QIMI)
Principal Investigator
Dr. Sonia Vanderby
Medical Imaging
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Farzad Moien-Afshari
Co-Investigator(s)
Jawahar Kalra
David Leswick
Martin Reed
2013-2014 Health Research Group Grants - Phase I
Two year
FUNDING RECEIVED
$30,000SHRF
Description
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Acute Intermittent Hypoxia - therapeutic potential for cervical spinal cord injuries
Principal Investigator
Dr. Valerie Verge
Cameco MS Neuroscience Research Center
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Jawahar Kalra
David Leswick
Martin Reed
2013-2014 Spinal Cord Injury Research Grants
Two year
FUNDING RECEIVED
$100,000SHRF
Description
The majority of spinal cord injuries occur at the cervical level. The recovery of arm and hand function is usually of the highest priority in these cases. Acute intermittent hypoxia (AIH: repeatedly breathing low oxygen levels for very short periods) is an emerging non-invasive therapy that is demonstrating improved function in respiratory and non-respiratory muscle-controlling nerve cells (neurons) in rats with partial cervical spinal cord injury (SCI). This therapy has th potential for strong translation into people. For example, AIH treatment has recently been shown to elicit sustained increases in voluntary limb muscle strength and to increase walking distance in persons with chronic SCI. However, we are far from understanding how broad an impact AIH may have on nervous system plasticity and recovery of function.Early results from the laboratory demonstrates limb function recovery improves after one week of AIH treatment when it is started four weeks post-cervical SCI and maintained for at least an additional four weeks. Dramatic affects have also been seen on expression of plasticity-associated genes in both motor and sensory neurons. These affects are also evident at the growing axon front on injured peripheral neurons, suggesting the impact of AIH extends beyond spared circuitry to one of the injured neurons. The purpose of this grant is to continue to research the cellular events and mechanisms associated with AIH and the promising recovery of limb function in cervical SCI rats so as to optimize the results and their translation to human trials.
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Regenerative neuronal reprogramming: elucidating and enhancing intrinsic repair programs
Principal Investigator
Dr. Valerie Verge
Cameco MS Neuroscience Research Center
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Jawahar Kalra
David Leswick
Martin Reed
2013-2014 RPP - Operating Grants
Two year
FUNDING RECEIVED
$147,540SHRF
$147,540CIHR
$295,080Total
Description
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Connecting salmonella persistence and virulence: examining the role of CsgD in regulating type III secretion
Principal Investigator
Dr. Yejun Wang
Vaccine and Infectious Disease Organization
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Jawahar Kalra
David Leswick
Martin Reed
Supervisor(s)
Dr. Aaron White (Lead Supervisor)
2013-2014 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
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The role of Insulin-like growth factor-1 (IGF-1) signaling on chronic phase and blast crisis phase of chronic myeloid leukemia
Principal Investigator
Mrs. Mahsa Abrishami
Biochemistry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Jawahar Kalra
David Leswick
Martin Reed
Supervisor(s)
Dr. Clarence Geyer (Lead Supervisor)
2012-2013 RPP - Doctoral Awards
Three year
FUNDING RECEIVED
$26,250Canadian Breast Cancer Foundation
$52,500CIHR
$26,250U of S
$105,000Total
Description
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Drug Discovery and Development Research Group
Principal Investigator
Dr. Jane Alcorn
Pharmacy and Nutrition
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Azita Haddadi
Anas El-Aneed
Terra Arnason
Ildiko Badea
Jian Yang
Brian Bandy
Edward Krol
Troy Harkness
Gordon Zello
2012-2013 Health Research Group Grants - Phase II
Three year
FUNDING RECEIVED
$300,000SHRF
Description
Chronic disease and its consequences resonate profoundly in all our lives; yet, we face an inadequacy of effective or affordable medications and have guarded confidence in the pharmaceutical industry. At the same time, Saskatchewan's agricultural products offer a wealth of compounds with strong potential for significant health benefits. The Drug Discovery and Development Research Group, led by Dr. Alcorn, fosters productive collaboration between Saskatchewan-based industry partners and academic researchers. With the purpose of advancing basic research into Saskatchewan agricultural products, they aim to improve therapeutic outcomes for patients and promote value-added uses for Saskatchewan agricultural products. By focusing on the well-established expertise of team members, they are currently studying the role of flaxseed lignans and Saskatoon Berry anthocyanins in chronic disease, as well as the repurposing of agents to break cancer resistance. They are also working collaboratively with outside agencies to advance discovery research of flaxseed byproducts. Over the period of this grant cycle, the research collaborative will provide important science-based evidence to promote promising compounds from Saskatchewan agricultural products as potential therapeutics for chronic disease. The group's proven track record of success will also support further partnerships that promote drug discovery of novel therapeutics under development at the University of Saskatchewan.
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Regulation of PTEN
Principal Investigator
Dr. Deborah Anderson
Cancer Research & Saskatchewan Cancer Agency
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Azita Haddadi
Anas El-Aneed
Terra Arnason
Ildiko Badea
Jian Yang
Brian Bandy
Edward Krol
Troy Harkness
Gordon Zello
2012-2013 RPP - Operating Grants
Two year
FUNDING RECEIVED
$140,159SHRF
$140,159CIHR
$280,318Total
Description
Many different kinds of human cancer have a common characteristic. A tumour suppressor protein, called PTEN, is often reduced in amount or is mutated, thereby reducing its function. In normal cells, PTEN functions to limit cell division and cell survival. When PTEN is mutated or in short supply, cell division and cell survival may be enhanced, resulting in a mass of cells or tumour. Dr. Deborah Anderson is characterizing PTEN mutations identified from human tumours to determine which of them contribute to cancer. Dr. Anderson and her lab have previously shown that a second protein called p85 can enhance PTEN's tumour suppressor function. As with PTEN, mutations in p85 have also been linked to human cancers. The researchers are building on their knowledge of p85 by exploring the impact of p85 mutations on PTEN's tumour suppressor function. The scope of these studies will help researchers determine which mutations in PTEN and p85 contribute to cancer. Identifying those mutations that contribute to cancer and those that have little or no effect will contribute to future diagnostic testing and treatment options.
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Charting networks of mitochondrial protein complexes in human neurodegenerative diseases
Principal Investigator
Dr. Mohan Babu
Chemistry and Biochemistry
Science
University of Regina
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Aaron Schimmer
Jodi Nunnari
ZhaoLei Zhang
2012-2013 Establishment Grants
Three year
FUNDING RECEIVED
$119,296SHRF
Description
Many diverse human disorders, particularly neurodegenerative diseases like Parkinson's, Alzheimer's, and Huntington's, occur as a result of defects in mitochondrial function. Mitochondria generate the majority of a cell's energy supply. Through integration with other organelles, they are required for a large number of cellular functions, including ion homeostasis, respiration, and programmed cell death. Dr. Babu is investigating mitochondrial defects as causative or contributing factors of these diseases. To date, studies have uncovered only a small number of mitochondrial proteins involved in neurodegenerative diseases. Given the diversity of processes affected by mitochondrial function, and because it is difficult to pinpoint the role of mitochondrial dysfunction in human disease, Dr. Babu believes that many more remain unknown. He is addressing the deficit by creating a detailed interaction map for a subset of neurological disease-causing proteins. Interaction networks are then being generated to identify protein candidates that are relevant to disease onset and progression.By isolating the similarities between human disorders, Dr. Babu's research will provide new insights into the complex causes of neurodegenerative diseases and offers hope for therapeutic advances that could ameliorate many diseases simultaneously.
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Investigating the yeast mitochondrial interactome for disease-gene discovery
Principal Investigator
Dr. Mohan Babu
Chemistry and Biochemistry
Science
University of Regina
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Aaron Schimmer
Jodi Nunnari
ZhaoLei Zhang
2012-2013 RPP - Operating Grants
Two year
FUNDING RECEIVED
$189,916SHRF
$189,916CIHR
$379,832Total
Description
One in 5,000 people suffers from a mitochondrial disease. The disease may be neurodegenerative, like Parkinson's, Alzheimer's, or Huntington's. It may be a respiratory disease or cancer. While mitochondrial dysfunction has been identified as a cause or contributor to human disease, its role is hard to pinpoint because the systems properties of the organelle are not understood. Dr. Babu's line of research is addressing this knowledge deficit. Studies in yeast have been instrumental to discovering the fundamental mechanisms underlying mitochondrial biology and disease. Mitochondria in yeast and human cells are physically associated with over 1,000 distinct nuclear-encoded mitochondrial proteins. Dr. Babu and his team of researchers are using the link between yeast and humans to map the networks of mitochondrial interactions that have potential disease associations. This innovative research will provide an unprecedented view of the system properties of mitochondria and will address the critical question of how mitochondrial processes are highly integrated with one another and with other cellular pathways. It will also create avenues for identifying novel therapeutic targets as well as therapies for the treatment of mitochondrial diseases.
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Ambulatory Activity of Older Adults in Acute Care
Principal Investigator
Dr. Jenny Basran
Division of Geriatric Medicine
Medicine
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Gillian Muir
Co-Investigator(s)
Catherine Arnold
Sandra Webber
2012-2013 Research Connections Grants
Two year
FUNDING RECEIVED
$5,000SHRF
Description
Limited mobility in hospitalized older adults is associated with negative outcomes -functional decline and new institutionalization. This by invitation only meeting at the Saskatoon Sheraton Cavalier Hotel May 29, 2012 will bring together patients, researchers, health care providers, and decision-makers to determine the feasibility of implementing an early ambulation intervention. Attendees will hear from international experts, review the literature and discuss results of an environmental scan conducted with Saskatoon Health Region. The goal is to finalise the intervention that will be studied in a multicenter, randomized control trial across Canada. This study will be led by the University of Saskatchewan team.
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Safe Water for Health Research Team (SWHRT)
Principal Investigator
Dr. Lalita Bharadwaj
Public Health
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Markus Hecker
Cindy Feng
Yelena Bird
Wolfgang Koester
Allan Cessna
Robert Patrick
Tasha Epp
2012-2013 Health Research Group Grants - Phase II
Three year
FUNDING RECEIVED
$299,140SHRF
Description
Limited access to safe water and sanitation is one of the most important global threats to human health. International studies have linked poor quality drinking water to chronic disease and cancer, yet drinking water quality is a concern for much of Saskatchewan's population who live outside major urban centers and often rely on groundwater to supply their homes. Access to safe drinking water is a particular concern for First Nations communities, with more than 70% of community water systems classified as medium or high risk in a 2011 national report. In its first phase of SHRF support, the Safe Water for Health Research Team, led by Drs. Bharadwaj and Waldner, evolved into a successful collaboration of researchers from several University of Saskatchewan colleges, other universities, government and Saskatchewan First Nations. Now, in the second phase of support, the group is investigating the geographic distribution of drinking water quality, the concentrations of individual parameters, and the mixtures or patterns of poor water quality and palatability. They are also using community-based risk assessment to characterize challenges related to poor drinking water quality in Saskatchewan. And they are evaluating the associations between water quality and chronic disease. The group intends to prove that poor water quality in many rural and remote communities in Saskatchewan increases the risk of important chronic diseases, including type II diabetes, cardiovascular disease and some forms of cancer. This work will provide data of value for regulatory and policy decision-making, surveillance, and development of population-based and health promotion interventions.
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Spotlight on Research: Alzheimer's Disease and Related Dementias
Principal Investigator
Ms. Joanne Bracken
Alzheimer Society of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Markus Hecker
Cindy Feng
Yelena Bird
Wolfgang Koester
Allan Cessna
Robert Patrick
Tasha Epp
2012-2013 Research Connections Grants
Three year
FUNDING RECEIVED
$5,000SHRF
Description
The Spotlight on Research event is an opportunity to connect and engage a broad range of stakeholders in the area of Alzheimer's disease and related dementias (ADRD) research. The event will also shine a spotlight on the need for continued focus on research into finding causes, treatments and cures and ways to continue to improve quality of life for those already affected. Participation will be open to the general public and in addition we will be inviting MLA's, representatives from the Ministry of Health, representatives from the Regina Qu'Appelle Health Region, people with dementia, family caregivers, donors and supporters of the Alzheimer Society. Attendance is free, but advance registration is requested by calling 1-306-949-4141 or online at www.alzheimer.ca/sk
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Innovations in Qualitative Research 2012
Principal Investigator
Dr. Carolyn Brooks
Sociology
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Markus Hecker
Cindy Feng
Yelena Bird
Wolfgang Koester
Allan Cessna
Robert Patrick
Tasha Epp
2012-2013 Research Connections Grants
Three year
FUNDING RECEIVED
$3,000SHRF
Description
The third Innovations in Qualitative Research Conference (IQRC 2012, University of Saskatchewan), will bring together Saskatchewan and Canadian Scholars and graduate students to explore innovations in the expanding field of qualitative health research and methodologies, build research capacity in human health and create opportunity for future collaborations. IQRC 2012 will be held Monday, June 11 to Wednesday, June 13 at St Thomas More College. It is expected that approximately 75 local, provincial and national scholars will attend this event.For more information contact: Laurie Schimpf at iqrc.2012@usask.ca or visit: http://drcprojects/iqrc/IQRC_2012.html
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Targeted disabled infectious single cycle (DISC) Bovine Adenovirus (BAdV)-3 as vaccine delivery vector
Principal Investigator
Dr. Kyle Brown
Vaccine and Infectious Disease Organization
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Markus Hecker
Cindy Feng
Yelena Bird
Wolfgang Koester
Allan Cessna
Robert Patrick
Tasha Epp
Supervisor(s)
Dr. Suresh Tikoo (Lead Supervisor)
2012-2013 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
Infectious diseases are the leading cause of death worldwide. In the last 20 years, at least 30 new diseases have been recognized around the world, including SARS, Ebola, cryptosporidiosis and HIV. Simultaneously, we are seeing the return of diseases from our past, such as tuberculosis, cholera, and diphtheria. The development of novel vaccines is an obvious necessity, along with appropriate methods for vaccine delivery. Dr. Kyle Brown is investigating a new means to deliver vaccines that circumvents many traditional complications. The use of viruses as vaccine carriers has proven to be effective in many cases; however, it is not uncommon for the human body to have already developed immunity against the virus. To overcome the immunological challenge, Dr. Brown and his team of researchers are developing a novel, non-human vaccine carrier that is unfamiliar to the human immune system, but is designed to target the appropriate cells.As the incidence of newly emerging infectious diseases rises within Canada, Dr. Brown's research will become increasingly important for its potential to provide a highly effective, safe vaccine carrier to combat the spread of disease from human to human and from animal to human.
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Biomedical Beamline Future Directions Forum
Principal Investigator
Dr. Dean Chapman
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
David Cooper
2012-2013 Research Connections Grants
Two year
FUNDING RECEIVED
$7,500SHRF
Description
This meeting will help determine the short and longer term development of the Biomedical Imaging and Therapy (BMIT) beamlines by identifying areas of clinically relevant research (both human and animal) that will be of strategic importance either because of an existing strength(s) or those areas where strength should be developed. This information will help guide the BMIT beamteam, beamline staff and CLS regarding priorities for the development of the beamline. Invited speakers represent a broad mix of national and international experts in areas of relevance to BMIT.This is an open meeting to anyone interested in the use of or the future research directions of the Biomedical Imaging and Therapy beamline facility at the Canadian Light Source.
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Tissue Engineering Research Group
Principal Investigator
Dr. Xiongbiao (Daniel) Chen
Mechanical Engineering
Engineering
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Brian Eames
James Bugg
Adam Wu
Ning Zhu
Don Bergstrom
Catherine Niu
William Dust
David Schreyer
William Kulyk
2012-2013 Health Research Group Grants - Phase III
Three year
FUNDING RECEIVED
$750,000SHRF
Description
Millions of people suffer from peripheral nerve injuries, osteoarthritis and/or stroke. Peripheral nerve injuries result from traumas that lead to loss of sensation and movement in the affected limb or body region. The conventional treatment approach is to surgically realign nerve endings. Osteoarthritis is a degenerative joint disease characterized by progressive erosion of the articular (joint) cartilage and treated by replacing joints with prosthetic implants of steel or other artificial materials. A stroke is the rapid loss of brain function due to a disturbance in the blood supply to the brain and is attended through endovascular treatment by selective coining. With all of these conditions, the level of recovery is highly variable and the return of function is almost never complete. The Tissue Engineering Research Group, led by Dr. Chen, is investigating the use of biodegradable scaffolds or stents for peripheral nerve repair, cartilage repair and stroke treatment by testing their ability to promote tissue regeneration. Synchrotron-based biomedical imaging technologies are being developed as a way to characterize the post-tissue samples and the scaffolds or stents. Dr. Chen's group believes that engineering the biodegradable scaffolds or stents with carefully controlled microstructure and microscopic arrangements of bioactive agents can make significant advances. To this end, the group is developing novel methods to advance the theoretical and practical basis of producing biodegradable scaffolds or stents for application to human patients.
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Evaluating the use of exposure to alleviate distress in caregivers of child victims of interpersonal trauma
Principal Investigator
Dr. Jorden Cummings
Psychology
Arts and Science
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Brian Eames
James Bugg
Adam Wu
Ning Zhu
Don Bergstrom
Catherine Niu
William Dust
David Schreyer
William Kulyk
2012-2013 Establishment Grants
Three year
FUNDING RECEIVED
$83,885SHRF
Description
Children experience interpersonal trauma, such as sexual abuse, at disturbingly high rates. While the negative psychosocial impact on child victims of interpersonal trauma is well documented, research indicates that the parents and guardians of these children also experience substantial distress, psychological symptoms such as depression and posttraumatic stress (PTSD), increased worry, and impaired parenting following their child's trauma. Dr. Jorden Cummings is evaluating the effectiveness of an exposure-based intervention for caregivers whose children have experienced interpersonal trauma. Typically in exposure therapy, a survivor confronts feelings, phobias or anxieties about a traumatic event by reliving it in the therapy situation. Dr. Cummings is filling a void where there are currently no established interventions by extending the application of exposure therapy to situations where the clients have not directly experienced the trauma. By creating an intervention for caregivers, they can become more involved in the child's psychotherapy, providing an important protective factor against child mental health concerns and enabling greater symptom relief for both the child and the caregivers. This project has important implications for treatment development and service delivery for families affected by interpersonal trauma. Dr. Cummings believes the development of such interventions will have a positive impact on the caregivers and the child victims themselves.
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Profiling prostate cancer patients' preferences to facilitate treatment decision making
Principal Investigator
Dr. Barbara (Joyce) Davison
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Michael Szafron
Carl Gutwin
Kishore Visvanathan
2012-2013 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Prostate cancer is diagnosed more frequently than any other cancer in men aged 60 to 69 years. No other cancer has so many available treatment options that men must consider at the time of diagnosis. Dr. Joyce Davison is exploring methods to improve the treatment decision-making experience of men newly diagnosed with prostate cancer. An internet-based decision support program entitled "Decision Support Intervention-Prostate Cancer (DIS-PC)" is being used by 200 patients to produce a summary page identifying their personal preferences regarding the degree to which they want to participate in treatment decision-making with their physician, the type and amount of information they wish to access, and the factors influencing their decision. Patients are being instructed to share this information with their health care professionals at all treatment discussions. After a treatment decision has been made, patients will be resurveyed with respect to treatment decision conflict, control and satisfaction.The objectives of the research are to identify and compare levels of decision conflict and control prior to and following the treatment decision, measure men's levels of satisfaction with their treatment decision and determine if the order that health information is presented influences patient responses. Dr. Davison hopes this innovative project will improve patient-centred care in Saskatchewan by helping older male cancer patients make treatment decisions consistent with their personal preferences and values.
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Molecular mechanism of the human copper transporting ATPases
Principal Investigator
Dr. Oleg Dmitriev
Biochemistry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Graham George
Yu Luo
2012-2013 RPP - Operating Grants
Two year
FUNDING RECEIVED
$140,860SHRF
$140,860CIHR
$281,720Total
Description
Copper is essential to the human body because it is required for the activity of many enzymes involved in respiration, neuron function, formation of connective tissue, endocrine processes, and radical detoxification. In some diseases, the body's ability to transport copper is disrupted. Dr. Oleg Dmitriev is studying the ability of the Wilson disease protein to regulate copper concentration in the cell, deliver copper to biosynthetic pathways, and increase cancer resistance to chemotherapeutic drugs. To understand the critical steps in the activity cycle of the copper transporters, Dr. Dmitriev and his team of researchers will investigate the structure, molecular motions and interactions of the isolated domains, or functional modules, of the Wilson disease protein. By collecting structural information on Wilson disease protein, they will be able to design new inhibitors and modulators of copper transporters. Then, using synchrotron radiation from the Canadian Light Source, Nuclear Magnetic Resonance, and biochemical techniques, they will further investigate the role of Wilson disease protein in cancer resistance to anticancer drugs. This work is expected to improve the understanding of an important class of transport proteins and provide a new insight into the molecular basis of the disorders of copper metabolism. Dr. Dmitriev hopes his research will ultimately help to overcome certain types of drug resistance in cancer.
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Temporal regulation of skeletal cell differentiation by proteoglycan-dependent growth factor signaling
Principal Investigator
Dr. Brian Eames
Anatomy and Cell Biology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Graham George
Yu Luo
2012-2013 Establishment Grants
Three year
FUNDING RECEIVED
$120,000SHRF
Description
Osteoarthritis is a major obstacle to work productivity and quality of life for many Canadians, affecting over 10 per cent of the general population and 15 per cent of Saskatchewanians. More than 40 per cent of Canadians over the age of 65 are affected by the disease's symptoms of joint pain, tenderness, stiffness, locking and sometimes effusions. Dr. Brian Eames is investigating experimental systems that will contribute to our knowledge and treatment of osteoarthritis, as well as novel imaging methods to aid in detection.In his research, Dr. Eames is exploring the defects associated with osteoarthritis that together degrade the cartilage protecting the bones, leaving them exposed and susceptible to damage. Using zebrafish as his research model of human development and disease, he is working at the cellular and molecular level. He and his team of researchers are using a wide variety of tools made possible by the zebrafish model, including the Canadian Light Source Synchrotron, to create a unique experimental system. Dr. Eames is working toward a goal of developing novel experimental systems that provide a fresh, unexplored avenue for understanding, detecting and eventually treating osteoarthritis.
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Indigenous Peoples' Health Research Centre
Principal Investigator
Dr. Jo-Ann Episkenew
Indigenous Peoples' Health Research Centre
Indigenous Peoples' Health Research Centre
University of Regina
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Carolyn Brooks
Jennifer Poudrier
Charity Marsh
JoLee Sasakamoose
Greg Marchildon
Linda Goulet
Charlotte Reading
Warren Linds
Nuno Ribiero
2012-2013 Health Research Group Grants - Phase III
Three year
FUNDING RECEIVED
$750,000SHRF
Description
The health of Aboriginal peoples in Canada ranks alarmingly low in a variety of indicators. These measures paint a bleak picture for Aboriginal youth, especially in rural and remote areas. Wide gaps in Aboriginal youth health research exist, particularly with regard to culturally relevant research methodologies, capacity building and policy formulation. Under the leadership of Dr. Episkenew, the Indigenous Peoples' Health Research Centre is working to give continuity in the area of Aboriginal health, with an emphasis on Aboriginal youth health. The centre is expanding its efforts to develop culturally appropriate, cost-effective health interventions among Aboriginal youth using indigenous and arts-based methods. The third phase of the research is expanding arts-based health interventions targeting Aboriginal youths to rural and remote Saskatchewan communities. It is refining and advancing research methodologies dealing with Aboriginal youth health and formulating best practices for future research. And it is increasing existing Aboriginal health capacity by providing health advocacy and research training to a cohort of Aboriginal youth who will have a positive impact on the health of their communities. Long-term objectives are to formulate culturally relevant public policies at the provincial and national level and establish synergies between a diverse and multidisciplinary group of scholars.
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Muscle adiposity in older adults: Relationships with physical function, activity, and fall status
Principal Investigator
Mr. Andrew Frank
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Carolyn Brooks
Jennifer Poudrier
Charity Marsh
JoLee Sasakamoose
Greg Marchildon
Linda Goulet
Charlotte Reading
Warren Linds
Nuno Ribiero
Supervisor(s)
Dr. Saija Kontulainen (Lead Supervisor)
2012-2013 RPP - Doctoral Awards
Three year
FUNDING RECEIVED
$52,500CIHR
$52,500U of S
$105,000Total
Description
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An efficacy trial of therapist assisted internet cognitive behaviour therapy program for individuals with a chronic heart condition
Principal Investigator
Ms. Lindsay Friesen
Psychology
Arts
University of Regina
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Carolyn Brooks
Jennifer Poudrier
Charity Marsh
JoLee Sasakamoose
Greg Marchildon
Linda Goulet
Charlotte Reading
Warren Linds
Nuno Ribiero
Supervisor(s)
Dr. Heather Hadjistavropoulos (Lead Supervisor)
2012-2013 RPP - Doctoral Awards
Three year
FUNDING RECEIVED
$52,500CIHR
$52,500U of R
$105,000Total
Description
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Searching for approaches to measure the effect of population health interventions: Integrating natural experiments and casual modelling
Principal Investigator
Dr. Daniel Fuller
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Carolyn Brooks
Jennifer Poudrier
Charity Marsh
JoLee Sasakamoose
Greg Marchildon
Linda Goulet
Charlotte Reading
Warren Linds
Nuno Ribiero
Supervisor(s)
Dr. Cory Neudorf (Lead Supervisor) Erin Strumpf (Supervisor)
2012-2013 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
Description
Award declined by recipient
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Searching for approaches to measure the effect of population health interventions: Integrating natural experiments and causal modelling.
Principal Investigator
Dr. Daniel Fuller
Community Health and Epidemiology
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Carolyn Brooks
Jennifer Poudrier
Charity Marsh
JoLee Sasakamoose
Greg Marchildon
Linda Goulet
Charlotte Reading
Warren Linds
Nuno Ribiero
Supervisor(s)
Dr. Cory Neudorf (Lead Supervisor) Erin Strumpf (Supervisor)
2012-2013 Research Fellowship Top-up Incentive Award
Two year
FUNDING RECEIVED
$20,000SHRF
Description
Programs implemented at the population level, like transportation and anti-smoking laws, are difficult to evaluate. Factors such as age and income can bias the results. Randomized controlled trials offer the traditional way to control this bias, but even they have weaknesses when it comes to understanding population level programs. Dr. Daniel Fuller is exploring new research methods that maintain the positive aspects of randomized control trials while improving on some of their weaknesses. Using causal modeling methods, Dr. Fuller is evaluating two population level programs, an intervention in schools to improve mental health and physical activity, and a smoking ban in the city of Saskatoon. The evaluation methods include propensity score matching and difference-in-differences.Improving evaluations of population level programs will contribute to our understanding of the impact of social and cultural biases. Dr. Fuller hopes his research will facilitate the adaptation of current and future population programming to ensure they are beneficial to population health.
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Presenilin-1: At the intersection between diabetes, depression and Alzheimer's disease?
Principal Investigator
Dr. Sarika Garg
Psychiatry
Medicine
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Carolyn Brooks
Jennifer Poudrier
Charity Marsh
JoLee Sasakamoose
Greg Marchildon
Linda Goulet
Charlotte Reading
Warren Linds
Nuno Ribiero
Supervisor(s)
Dr. Darrell Mousseau (Lead Supervisor)
2012-2013 Postdoctoral Research Fellowships
Two year
FUNDING RECEIVED
$100,000SHRF
Description
The risk of diabetes, depression and Alzheimer's disease increases with age, an important fact in Saskatchewan where 15.4 per cent of the population is 65 years or older. Diabetes and depression are risk factors for Alzheimer's disease, yet the intersection between these three diseases is still not known. Dr. Sarika Garg has identified a protein that plays a role in all three diseases and is investigating the possibility that it is the molecular intersection between them. Because therapies for Alzheimer's disease are often started after brain cells have already been damaged, these therapies are largely ineffective. As there is no cure for Alzheimer's disease, identifying early brain changes could provide the necessary information for an effective intervention. By increasing our understanding of how Alzheimer's disease is associated with diabetes and depression, Dr. Garg hopes to isolate a potential target that, when treated for diabetes and depression, may also provide a preventive therapy for individuals at risk of Alzheimer's disease.Dr. Garg's research promises to improve our knowledge of how depression and diabetes can lead to Alzheimer's disease and how, by treating for these diseases, Alzheimer's disease may be avoided.
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Developing Synergies in Complex Continuing Care
Principal Investigator
Dr. Donna Goodridge
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Jenny Basran
2012-2013 Research Connections Grants
Two year
FUNDING RECEIVED
$8,000SHRF
Description
The overall objective of the meetings are to: a) consult with and foster new partnerships with key researchers with expertise in complex continuing care; b) create research and practice synergies with other health regions within Saskatchewan and c) disseminate research-based evidence on complex continuing care initiatives to a broad range of stakeholders within the province of Saskatchewan.The meetings are to be held November 30, 2012 in Saskatoon.For more information, please contact Alana Kolendreski at 966-2098 or Alana.kolendreski@usask.ca
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Restoring Indigenous miyo-mahcihoy?n (physical, mental, emotional, and spiritual) well-being
Principal Investigator
Dr. Holly Graham-Marrs
Nursing
University of Saskatchewan
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Peter Butt
Vivian Ramsden
2012-2013 Establishment Grants
Three year
FUNDING RECEIVED
$118,404SHRF
Description
Indigenous peoples do not have the same health status as other Canadians, and these health disparities contribute to increased costs and have an impact on the quality of life for both Indigenous and non-Indigenous peoples. Dr. Holly Graham-Marrs is developing a community-based program to facilitate empowerment and improve health and well-being within the Thunderchild First Nation.The medicine wheel, an Indigenous paradigm/model that embraces a holistic approach to health and well-being, is providing the conceptual framework for the project. Dr. Graham-Marrs is using action research and participatory processes to guide the research process and relationship with the community. Interviews are being conducted with youth and Elders, guided by narrative inquiry. Data analysis is being conducted according to the principles of thematic narrative analysis. Defining and measuring success of the community-based plan will be a collaborative endeavour with the community using Arnstein's Ladder as the frame, as well as Rissel's Model of Community Empowerment which links personal and community empowerment with collective action.By collaboratively developing, implementing, and evaluating a community-based program with the Plains Cree people of the Thunderchild First Nation, Dr. Graham-Marrs and her team hope to add to evidence-informed strategies and processes that facilitate empowerment in and with First Nation communities.
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Inspire: Health Care Quality Summit
Principal Investigator
Ms. Jade Gulash
Health Quality Council
Co-Principal Investigator(s)
Dr. Cheryl Waldner
Co-Investigator(s)
Debra-Jane Wright
2012-2013 Research Connections Grants
Three year
FUNDING RECEIVED
$1,000SHRF
Description
The Health Care Quality Summit taking place April 10-11, 2013 at Queensbury Convention Centre, Evraz Place, Regina, SK will bring together over 700 health care providers, managers, senior leaders, administrators, support staff, stakeholders, patients and family members. For two days, we will learn from each other and from world-leading experts in health care improvement. The goal of the Summit is to inspire, to learn, and to discuss how we can make improvements in health care for our patients in Saskatchewan.This event is by invitation only. Web site: www.qualitysummit.ca. Please contact Jade Gulash with any questions.
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Managing arthritis using physical activity: Identifying disease- and activity-specific psychosocial beliefs to improve adherence
Principal Investigator
Dr. Nancy Gyurcsik
Kinesiology
University of Saskatchewan
Co-Principal Investigator(s)